A5076494418- Celiac Disease Research and Management
- Microscopic Colitis
- Galectins and Cancer Biology
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
Garvan Institute of Medical Research
2021-2024
Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy. Second-generation vaccines will need to elicit neutralizing antibodies against sites that evolutionarily conserved across the sarbecovirus subgenus. Here, we immunized mice containing a human antibody repertoire with diverse receptor-binding domains (RBDs) identify targeting of vulnerability. Antibodies broad reactivity clade B RBDs class 4 epitope, recurring IGHV/IGKV pairs, were readily elicited but...
Abstract Intestinal inflammation continues in a subset of celiac disease (CD) patients despite gluten-free diet. Here, by applying multiomic single cell analysis to duodenal biopsies, we find low-grade malignancies with lymphoma driver mutations refractory CD type 2 (RCD2) comprise surface CD3 negative (sCD3-) lymphocytes stalled at an innate lymphoid (ILC) - progenitor T stage undergoing extensive TCR recombination. In people 1 (RCD1), who currently lack explanation, discover sCD3+ cells...