Periodontal disease is driven by dysbiosis in the oral microbiome, resulting over-representation of species that induce release pro-inflammatory cytokines, chemokines, and tissue-remodeling matrix metalloproteinases (MMPs) periodontium. These chronic tissue-destructive inflammatory responses result gradual loss tooth-supporting alveolar bone. The spirochete Treponema denticola , consistently found at significantly elevated levels periodontal lesions. Host-expressed Toll-Like Receptor 2...

Objective Ultraviolet (UV) and infrared (IR) lasers can be used to specifically target protein, water, mineral, respectively, in dental hard tissues produce varying changes surface morphology, permeability, reflectivity, acid resistance. The purpose of this study was explore the influence laser irradiation topical fluoride application on resistance enamel dentin shed light mechanism interaction develop more effective treatments. Methods Twelve bovine surfaces twelve were irradiated with...

A transparent highly mineralized outer surface zone is formed on caries lesions during remineralization that reduces the permeability to water and plaque generated acids. However, it has not been established how thick should be inhibit penetration of these fluids. Near-IR (NIR) reflectance coupled with dehydration can used measure changes in fluid enamel dentin. Based our previous studies, we postulate there a strong correlation between layer thickness rate dehydration. In this study, rates...

Significance: Leakage in the interfaces between restorative materials and tooth structure allows for fluid bacterial acid infiltration, causing restoration failure due to secondary caries. Dentists spend more time replacing composite restorations than placing new ones. Previous vitro vivo studies on enamel root surfaces using shortwave-infrared (SWIR) thermal imaging during dehydration with forced air have been promising assessing lesion activity.Aim: We hypothesized that SWIR reflectance...

Abstract Objectives The purpose of this study was to show that optical coherence tomography (OCT) and thermal imaging can be used monitor changes in the structure activity caries lesions over time after treatment with silver diamine fluoride (SDF). Methods Artificial were formed on enamel dentin bovine blocks. Each block partitioned into five windows central three exposed a demineralization solution create lesions: one sound window served as control (SC), SDF serve test (SCT), lesion (LC),...

We developed a clinical probe capable of acquiring simultaneous short wavelength infrared (SWIR) reflectance and occlusal transillumination images lesions on tooth proximal surfaces to reduce the potential false positives. The dual is 3D-printed imaging system uses Ge-enhanced camera fiber-optic light sources that use SWIR at 1300-nm for 1450-nm measurements. purpose this study was test performance extracted teeth prior commencing studies. used image with lesions. each were compared micro-CT...

New imaging methods are needed to assess the activity of caries lesions on tooth surfaces. Recent studies have shown that thermal root surfaces during dehydration with air can be used determine if active or arrested. In this study changes in emission extracted teeth was monitored using an system a miniature camera and 3D printed handpiece integrated nozzle suitable for clinical use. This evaluated performance prior it's use vivo studies. There significant difference response sound lesion...

New imaging methods are needed to assess the activity of caries lesions on tooth surfaces. Recent studies have shown that changes in contrast during dehydration with air at SWIR wavelengths can be used determine if active or arrested. In this study reflectance was monitored 1500-1750-nm extracted teeth using an system InGaAs camera, a light source and 3D printed handpiece integrated nozzle suitable for clinical use. Lesion structure also assessed optical coherence tomography microCT...

New imaging technologies are needed for the clinical assessment of lesions on root surfaces. It is not sufficient to simply detect caries lesions; methods assess lesion depth, structural composition and activity determine if chemical intervention has potential be effective remineralization occurred. Lesions were monitored using CP-OCT during dehydration structure any shrinkage. Thermal at 6-10 μm wavelengths short wavelength-IR 1450-1750-nm used monitor thermal emission activity. Imaging...

UV and IR lasers can be used to specifically target protein, water, the mineral phase of dental hard tissues produce varying changes in surface morphology. In this study, we irradiated enamel dentin surfaces with various combinations operating at 0.355, 2.94, 9.4 μm, exposed those topical fluoride, subsequently evaluated influence these on morphology permeability. Digital microscopy dehydration rate measurements were monitor samples overtime. The permeability (dehydration rate) varied...

Transparent remineralized surface zones found on natural caries lesions may reduce the permeability to water and plaque generated acids. Near-IR (NIR) reflectance imaging coupled with dehydration can be used measure changes in fluid of enamel dentin. Previous work demonstrated a negative association between zone thickness rate simulated lesions. In this study, rates transparent layer coronal extracted teeth were measured correlated. Reflectance at NIR wavelengths from 1695-1750 nm, which...

Secondary caries occurs when leakage in the interfaces between restorative materials and tooth structure allow fluid bacterial acid infiltration. Thermal imaging coupled with dehydration can be used to measure this increase permeability for secondary lesions teeth. exploits temperature change due water evaporation during rate of diffusion from porous lesion areas. Previous vitro vivo thermal studies on enamel root surfaces have been promising assessing natural activity. In study, rates...

This study investigated the utility of using OCT to monitor SDF application over time. Twenty dentin blocks each with 5 windows were exposed a demineralization solution produce carious lesions. Treatment included sound, sound+SDF, lesion, lesion+SDF, lesion+SDF+SDF. Lesion depth, mean reflectivity lesion depth and optical penetration through lesions monitored for 12 weeks. was able show changes in demineralized sound after Such can potentially be determine if when re-application is needed.

Purpose: Colonic perforation is one of the most serious complications colonoscopy. Surgical intervention standard treatment. The aim our study was to assess outcome laparoscopic surgery in treatment iatrogenic colonoscopic perforation.Methods: From January 2003 December 2010, data 12 consecutive patientswho had undergone for collected retrospective review.Results: Eight patients were men; mean age 56 years. received therapeutic procedures form a polypectomy. Most sites sigmoid colon (n = 8)....

Optical coherence tomography (OCT) can acquire high-resolution images of lesion structure in vivo to assess activity. The surface layers arrested enamel caries lesions (ECLs) have a higher mineral content than the body with reduced porosity that inhibits penetration fluids into and appears reflectivity OCT. This study aimed use microcomputed (microCT) measure transparent layer (TSL) on OCT images. microCT were used relative density profiles 20 bovine samples had simulated ECLs, 44 extracted...

Previous studies have shown that optical coherence tomography (OCT) can be used to show the formation of a transparent surface zone on caries lesions indicative remineralization. Studies also monitoring changes in diffuse reflectivity during drying with air assess lesion activity and largest occur at SWIR wavelengths coincident high water absorption 1450 1950 nm. The purpose this study was determine when remineralization has occurred by reflectance measurements OCT images simulated over an...