A5017881221- Oral microbiology and periodontitis research
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Oral Health Pathology and Treatment
- Probiotics and Fermented Foods
- Lipid Membrane Structure and Behavior
- Gut microbiota and health
- Advancements in Transdermal Drug Delivery
- Advanced biosensing and bioanalysis techniques
- HIV/AIDS oral health manifestations
- Immune Response and Inflammation
- Nanoparticles: synthesis and applications
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Oral health in cancer treatment
- Protease and Inhibitor Mechanisms
- Bone and Dental Protein Studies
- Streptococcal Infections and Treatments
- Antimicrobial Peptides and Activities
- Salivary Gland Disorders and Functions
- Dental Health and Care Utilization
- Microfluidic and Capillary Electrophoresis Applications
- Caveolin-1 and cellular processes
- Therapeutic Uses of Natural Elements
- Endodontics and Root Canal Treatments
University of California, San Francisco
2019-2024
University of California, Los Angeles
2023-2024
Universidade Estadual de Campinas (UNICAMP)
2013-2021
University of Zagreb
1994
Abstract Oral microbiome dysbiosis mediates chronic periodontal disease, gut microbial dysbiosis, and mucosal barrier disfunction that leads to steatohepatitis via the enterohepatic circulation. Improving this towards health may improve liver disease. Treatment with antibiotics probiotics have been used modulate microbial, immunological, clinical landscape of disease some success. The aim present investigation was evaluate potential for nisin, an antimicrobial peptide produced by Lactococcus...
Oral dysbiosis is an imbalance in the oral microbiome and associated with a variety of systemic diseases, including periodontal disease, caries, head neck/oral cancer. Although antibiotics can be used to control this dysbiosis, they lead adverse side effects superinfections. Thus, novel strategies have been proposed address these shortcomings. One strategy use probiotics as antimicrobial agents, since are considered safe for humans environment. Specifically, Gram-positive Lactococcus lactis,...
Dysbiosis of the oral microbiome mediates chronic periodontal disease. Realignment microbial dysbiosis towards health may prevent Treatment with antibiotics and probiotics can modulate microbial, immunological, clinical landscape disease some success. Antibacterial peptides or bacteriocins, such as nisin, a nisin-producing probiotic, Lactococcus lactis, have not been examined in this context, yet warrant examination because their biomedical benefits eradicating biofilms pathogenic bacteria,...
Periodontitis-related oral microbial dysbiosis is thought to contribute Alzheimer's disease (AD) neuroinflammation and brain amyloid production. Since probiotics can modulate periodontitis/oral dysbiosis, this study examined the effects of a probiotic/lantibiotic, nisin, in modulating pathology triggered by periodontitis.
Bacteriocins are peptides produced by bacteria to inhibit the growth of other prokaryotes. Nisin is a bacteriocin widely used in food industry and for biomedical applications. However, bacteriocins have some limitations, as they experience mechanisms resistance, degradation proteases, suboptimal intracellular delivery. Combining with nanoscale drug delivery systems (nano-DDS) an approach that can help overcome these limitations. Among nano-DDS, solid lipid nanoparticles (SLN) been described...
Peri-implantitis is characterized by chronic inflammation of the peri-implant supporting tissues that progressively and irreversibly leads to bone loss and, consequently, implant loss. Similar periodontal disease, oral dysbiosis thought be a driver peri-implantitis. However, managing peri-implantitis with traditional treatment methods, such as nonsurgical debridement or surgery, not always successful. Thus, novel strategies have been proposed address these shortcomings. One strategy use...
Oral potentially malignant disorders (OPMDs) are a group of conditions that carry risk oral squamous cell carcinoma (OSCC) development. Recent studies indicate periodontal disease-associated pathogenic bacteria may play role in the transition from healthy mucosa to dysplasia and OSCC. Yet, microbial signatures associated with have not been established. To characterize at these different sites, we performed 16S sequencing analysis both swab formalin-fixed, paraffin-embedded tissue (FFPE)...
Several scientific hurdles still have to be overcome before gene therapy becomes a reality. One of them is the development safe and efficient delivery system. Here, we employed factorial design optimize production solid lipid nanoparticles (SLN) for delivery. A 2 x 3 full-factorial experimental was used optimization SLNs formulations. The variables were defined by components formulation: concentration stearic acid, DOTAP, Pluronic F68 at two levels (-1, 1) central points (0). Different SNL...
Periodontal disease is driven by dysbiosis in the oral microbiome, resulting over-representation of species that induce release pro-inflammatory cytokines, chemokines, and tissue-remodeling matrix metalloproteinases (MMPs) periodontium. These chronic tissue-destructive inflammatory responses result gradual loss tooth-supporting alveolar bone. The spirochete Treponema denticola , consistently found at significantly elevated levels periodontal lesions. Host-expressed Toll-Like Receptor 2...
Increased age is associated with an increased prevalence of chronic inflammatory diseases and conditions. The term inflammaging has been used to describe the age-related changes immune response that results in a elevated state contributes, part, disease older adults. Periodontal condition affects periodontium increases age. To better understand mechanisms drive inflammaging, broad body research focused on pathological key cellular regulators response. This review will focus our current...
Solid lipid nanoparticles (SLNs) are a promising system for the delivery of lipophilic and hydrophilic drugs. They consist solid core that is stabilized by layer surfactants. By incorporation cationic lipids in formulation, positively charged SLNs can be generated, suitable carriers nucleic acids (DNA, siRNA). Considering beneficial effect helper on transfection efficiency with liposomes, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) lipid-containing was investigated PC3 prostate...