A5022418072- Oral microbiology and periodontitis research
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Oral Health Pathology and Treatment
- Periodontal Regeneration and Treatments
- Dental Health and Care Utilization
- HIV/AIDS oral health manifestations
- Gut microbiota and health
- Dental Implant Techniques and Outcomes
- Probiotics and Fermented Foods
- Bone and Dental Protein Studies
- Streptococcal Infections and Treatments
- Endodontics and Root Canal Treatments
- Salivary Gland Disorders and Functions
- Dental Radiography and Imaging
- Cell death mechanisms and regulation
- Oral and gingival health research
- Metabolomics and Mass Spectrometry Studies
- Proteoglycans and glycosaminoglycans research
- Sirtuins and Resveratrol in Medicine
- Cancer Research and Treatments
- Head and Neck Cancer Studies
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- dental development and anomalies
University of California, Los Angeles
2022-2025
University of California, San Francisco
2004-2024
British Society of Periodontology
2022
Ada Technologies (United States)
2022
Nippon Dental University
2021
Université Paris Cité
2021
University of Michigan
2009-2020
IFC Research (United Kingdom)
2016
Michigan United
2011-2015
Michigan Center for Translational Pathology
2011
Abstract Periodontal health is defined by absence of clinically detectable inflammation. There a biological level immune surveillance that consistent with clinical gingival and homeostasis. Clinical may be found in periodontium intact, i.e. without attachment loss or bone loss, on reduced either non‐periodontitis patient (e.g. patients some form recession following crown lengthening surgery) history periodontitis who currently periodontally stable. can restored treatment gingivitis...
Periodontal health is defined by absence of clinically detectable inflammation. There a biological level immune surveillance that consistent with clinical gingival and homeostasis. Clinical may be found in periodontium intact, i.e. without attachment loss or bone loss, on reduced either non-periodontitis patient (e.g. patients some form recession following crown lengthening surgery) history periodontitis who currently periodontally stable. can restored treatment gingivitis periodontitis....
Abstract Nisin, a bacteriocin and commonly used food preservative, may serve as novel potential therapeutic for treating head neck squamous cell carcinoma ( HNSCC ), it induces preferential apoptosis, cycle arrest, reduces proliferation in cells, compared with primary keratinocytes. Nisin also tumorigenesis vivo. Mechanistically, nisin exerts these effects on , part, through CHAC 1, proapoptotic cation transport regulator, concomitant 1‐independent influx of extracellular calcium. In...
The use of small antimicrobial peptides or bacteriocins, like nisin, to treat cancer is a new approach that holds great promise. Nisin exemplifies this because it has been used safely in humans for many years as food preservative, and recent laboratory studies support its anti-tumor potential head neck cancer. Previously, we showed nisin (2.5%, low content) antitumor squamous cell carcinoma (HNSCC) vitro vivo. current explored naturally occurring variant (nisin ZP; 95%, high effects ZP...
Although mesenchymal progenitor cells can be isolated from periodontal ligament (PDL) tissues using stem cell markers STRO-1 and CD146, the proportion of these that have capacity to differentiate into multiple lineages remains determined. This study was designed quantify proportions primary human PDL undergo multilineage differentiation compare magnitude capabilities relative bone marrow-derived (MSCs) parental (PPDL) cells. (PMP) were PPDL CD146. The colony-forming efficiency potential PMP,...
Abstract BACKGROUND: Several sirtuin family members (SIRT1‐7), which are evolutionarily conserved NAD‐dependent deacetylases, play an important role in carcinogenesis. However, their oral cancer has not yet been investigated. Therefore, the objective of this study was to investigate whether sirtuins a METHODS: The expression levels all several squamous cell carcinoma (OSCC) lines were compared with normal human keratinocytes and observed that SIRT3 highly expressed. tissue microarrays used...
Dental pulp cells can differentiate toward an odontoblastic phenotype to produce reparative dentin beneath caries lesions. However, the mechanisms involved in cell differentiation under pro-inflammatory stimuli have not been well-explored. Thus, we hypothesized that cytokine tumor necrosis factor-alpha (TNF-alpha) could be a mediator dental phenotype. We observed TNF-alpha-challenged exhibited increased mineralization and early expression of phosphoprotein (DPP), sialoprotein (DSP), matrix...
Nisin is a lantibiotic widely used for the preservation of food and beverages. Recently, investigators have reported that nisin may clinical applications treating bacterial infections. The aim this study was to investigate effects ultra pure grade ZP (>95% purity) on taxonomically diverse bacteria common human oral cavity saliva derived multi-species biofilms, discern toxicity against cells relevant cavity.The minimum inhibitory concentrations bactericidal distinct were determined using agar...
Epidemiological studies reveal significant associations between periodontitis and oral cancer. However, knowledge about the contribution of periodontal pathogens to cancer potential regulatory mechanisms involved is limited. Previously, we showed that nisin, a bacteriocin commonly used food preservative, reduced tumorigenesis extended life expectancy in tumor-bearing mice. In addition, nisin has antimicrobial effects on key pathogens. Thus, purpose this study was test hypothesis...
Abstract Oral microbiome dysbiosis mediates chronic periodontal disease, gut microbial dysbiosis, and mucosal barrier disfunction that leads to steatohepatitis via the enterohepatic circulation. Improving this towards health may improve liver disease. Treatment with antibiotics probiotics have been used modulate microbial, immunological, clinical landscape of disease some success. The aim present investigation was evaluate potential for nisin, an antimicrobial peptide produced by Lactococcus...
Resistance to anoikis, or apoptosis triggered by detachment from the extracellular matrix (ECM), lengthens survival of malignant cells, facilitating reattachment and colonization secondary sites. To examine molecular mechanisms underlying resistance anoikis in human oral squamous cell carcinoma (SCC) we cultured (HSC-3) cells suspension on plates coated with poly-2-hydroxyethyl methacrylate, which blocks access ECM. Cells that formed multicellular aggregates had significantly lower levels...
High-resolution magic-angle spinning (HR-MAS) proton NMR spectroscopy is used to explore the metabolic signatures of head and neck squamous cell carcinoma (HNSCC) which included matched normal adjacent tissue (NAT) tumor originating from tongue, lip, larynx oral cavity, associated lymph-node metastatic (LN-Met) tissues. A total 43 tissues (18 NAT, 18 Tumor 7 LN-Met) 22 HNSCC patients were analyzed. Principal Component Analysis data showed a clear classification between NAT tissues, however,...