A5009555055- Diabetes Treatment and Management
- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Metabolism, Diabetes, and Cancer
- Pharmaceutical studies and practices
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Antibiotics Pharmacokinetics and Efficacy
- Cardiovascular Syncope and Autonomic Disorders
- Primary Care and Health Outcomes
- Pharmacology and Obesity Treatment
- Potassium and Related Disorders
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects and Toxicity Studies
- Diabetes Management and Research
- Diet and metabolism studies
- Adrenal Hormones and Disorders
- Gastroesophageal reflux and treatments
- Psoriasis: Treatment and Pathogenesis
- Cardiovascular Function and Risk Factors
- Chronic Disease Management Strategies
- Healthcare Policy and Management
- Sympathectomy and Hyperhidrosis Treatments
- Opioid Use Disorder Treatment
Flinders Medical Centre
2014-2025
Flinders University
2015-2025
Women's and Children's Health Network
2024
Royal Adelaide Hospital
2013-2014
Repatriation General Hospital
2013
American Pharmacists Association
2013
University of Otago
2013
Patients with Addison's disease (AD) report impaired subjective health status (SHS). Since cortisol exhibits a robust circadian cycle that entrains other biological clocks, SHS may be due to the noncircadian profile achieved conventional glucocorticoid replacement. Continuous subcutaneous hydrocortisone infusion (CSHI) reproduces profile, but its effects on have not been objectively evaluated.The aim of this study was determine effect CSHI in AD.This multicentre, double-blind,...
The aim of this study is to compare metrics specific for stress-induced hyperglycemia (SIH) with glucose predicting ischemic stroke outcome.This observational retrospective (n = 300) included patients acutely hospitalized over a 3.8-year period. We assessed the association between acute outcome stress ratio (SHR, relative increase in glycemia) and glycemic gap (GG, absolute using admission values 5-day maximum values, along incidence poor above recognized clinical thresholds 10 mmol/L, SHR...
Background. Local health services make limited use of economic evaluation to inform decisions fund new service interventions. One barrier is the relevance published intervention effects local setting, given these can strongly reflect original context. Expert elicitation methods provide a structured approach explicitly and transparently adjust effect estimates, which then be used in local-level evaluations increase their relevance. was estimates for 2 interventions targeting prevention...
Objectives To investigate statin use and pain in people with cancer aged 70 to 79 80 older. Design Cross‐sectional. Setting Medical oncology outpatient clinic at the Royal Adelaide Hospital. Participants Individuals older who presented consecutively between January 2009 June 2010 (n = 385), of whom 106 were Measurements completed a structured data collection instrument, documenting medication use, comorbidities general assessment (10‐point visual analogue scale ( VAS )). Unadjusted adjusted...
Factitious Cushing's syndrome is extremely rare. The diagnosis challenging as cross-reactivity of synthetic corticosteroids or their metabolites in immunoassay measurements plasma urinary cortisol can make distinguishing between true and factitious difficult. Adrenocorticotropin (ACTH) usually suppressed syndrome.A 54-year-old woman presented with clinical biochemical features an unsuppressed ACTH concentration. She denied recent exogenous corticosteroid use.Initial investigations revealed a...
Pharmacology of SGLT2 inhibitorsThe first two inhibitors approved in Australia, dapagliflozin and canagliflozin, have high bioavailability.They a half-life about 12 hours are taken once day.Dapagliflozin can be with or without food, while it is recommended that canagliflozin before the meal day.Both drugs highly protein bound plasma metabolised liver via glucuronidation.
Abstract Objectives Published evidence on health service interventions should inform decision-making in local services, but primary effectiveness studies and cost-effectiveness analyses are unlikely to reflect contexts other than those which the evaluations were undertaken. A ten-step framework was developed applied use published as basis for local-level economic that estimate expected costs effects of new intervention options specific contexts. Methods Working with a multidisciplinary group...
Abstract Antiviral drugs were rapidly implemented into clinical practice for the treatment of high‐risk patients with COVID‐19, prompting development statewide guidelines. This South‐Australian study reviewed guideline adherence, assessed prescribing patterns and highlighted inappropriate management relative drug–drug interactions dosing renal function. Additionally, it evaluated impact antiviral drug use suggested methods to improve quality medicines.
Therapeutic drug safety for Indigenous Australians: how do we close the gap?In setting of significant disease burden, lack data on Australia's population is concerning
Abstract Product information is often at odds with current evidence and guidelines inconsistent between products within classes. There no single ‘owner’ responsible for up‐to‐date medicines product information. Outdated increases the risk of inappropriate prescribing.
The aims of this study were to characterise the population pharmacokinetics metformin in patients receiving haemodialysis, and determine doses that will maintain median plasma concentrations below 5 mg L