A5089160557- Organic and Molecular Conductors Research
- Cancer therapeutics and mechanisms
- Organic Chemistry Cycloaddition Reactions
- DNA and Nucleic Acid Chemistry
- Magnetism in coordination complexes
- Lung Cancer Research Studies
- Advanced biosensing and bioanalysis techniques
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Radical Photochemical Reactions
- Oxidative Organic Chemistry Reactions
- Ovarian cancer diagnosis and treatment
- Metal complexes synthesis and properties
- Neutropenia and Cancer Infections
- RNA Interference and Gene Delivery
- Organometallic Complex Synthesis and Catalysis
- Porphyrin and Phthalocyanine Chemistry
- GaN-based semiconductor devices and materials
- Inorganic and Organometallic Chemistry
- Metal-Catalyzed Oxygenation Mechanisms
- Endometrial and Cervical Cancer Treatments
- Synthesis and Catalytic Reactions
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Estrogen and related hormone effects
- Synthesis and Characterization of Heterocyclic Compounds
Teikyo University
2016-2023
Hokkaido University
2022
Toshiba (Japan)
2002-2020
Iwate Medical University
2003-2016
The University of Tokyo
1994-2015
Tokyo University of the Arts
2005-2015
Sophia University
2002-2013
Meijo University
2010-2013
Osaka City General Hospital
2011
Aichi Cancer Center
2011
High-performance GaInN-based solar cells with high open-circuit voltage, short-circuit current density, and good fill factor have been obtained using a combination of two different GaInN superlattice structures. The barrier thicknesses (3 0.6 nm) in both structures were optimized, resulting thick active layer low pit density the device. conversion efficiency is approximately 2.5% under simulator air mass 1.5G an irradiation intensity 155 mW/cm2.
The aim of this study was to investigate heat-shock protein (Hsp)70 as a novel marker evaluate the curative effects treatment for preterm delivery high-risk patients and pre-eclampsia.After obtaining informed consent, serum samples were collected from 31 with tocolysis index three points or above (A), seven pre-eclampsia (P), 46 normal pregnant women (B), non-pregnant (C). Of patients, 15 had (Ap) 16 full-term (Af). levels Hsp70 measured using enzyme-linked immunosorbent assay.The in 8.6 +/-...
Abstract The syntheses and unique chemical properties of metalladithiolene rings (especially in [CpM(S2C2R1R2)]-type complexes) found by our research group are reviewed. constructions one-pot reaction among [CpM(CO)n], alkyne, elemental sulfur the between [CpM(CO)n] sulfur-containing heterocyclic compounds described. Several ionic radical substitution reactions presented. substitutions carbon-centered sulfur-centered radicals occur rings. Benzoyloxy-substitution dibenzoyl peroxide (BPO)...
Irinotecan is a prodrug that hydrolyzed by carboxylesterase in vivo to form an active metabolite SN-38. SN-38 further conjugated and detoxified UDP-glucuronosyltransferase (UGT) yield its β-glucuronide (SN-38G). Although irinotecan widely used, the drug causes unpredictably severe, occasionally fatal, toxicity of leukopenia or diarrhea. Interindividual variation sensitivity related large variations biotransformation SN-38, some which would be caused genetic polymorphism UGT1A1, isozyme...
To evaluate the response rate and toxicity of combination irinotecan (CPT-11) cisplatin in a neoadjuvant setting, phase II study was conducted regarding regimen this patients with locally advanced cervical cancer. Eligibility included previously untreated stage Ib2, IIb, or IIIb squamous cell carcinoma good performance status. CPT-11 (60 mg m(-2)) administered intravenously on days 1, 8 15, followed by given day 1. Treatment repeated every 4 weeks for total two three cycles. Among 23...
The prognostic significance of PTEN expression in endometrial carcinoma has not been clear. We conducted the present study to clarify relationship between and prognosis advanced carcinoma. Of 784 patients with who underwent primary treatment 1985 2000 at 5 institutions, 98 pure endometrioid carcinomas retroperitoneal lymph node metastasis were provided for our study. was determined by immunohistochemic staining. Negative or mixed staining observed 64 (65.3%) patients. survival rate...
In Asians, the risk of irinotecan-induced severe toxicities is related in part to UGT1A1*6 (UGT, UDP glucuronosyltransferase) and UGT1A1*28, variant alleles that reduce elimination SN-38, active metabolite irinotecan. We prospectively studied relation between UGT1A1 genotype safety irinotecan-based regimens Japanese patients with advanced colorectal cancer, then constructed a nomogram for predicting neutropenia first treatment cycle. Safety data were obtained from 1312 monitored during 3...
We discovered that Si-doped Al0.05Ga0.95N can be used to realize an extremely low-resistivity n-type layer at room temperature. In GaN, a resistivity of 2.7×10-3 Ω cm with carrier concentration 4.0×1019 cm-3 was almost saturated. contrast, minimum 5.9×10-4 produced electron and mobility 1.4×1020 70 cm2/V s, respectively. confirmed reduction in the differential resistance violet light-emitting diode high external quantum efficiency by using this Al0.05Ga0.95N.
Phosphorylation of histone H2AX (gammaH2AX) is a sensitive marker DNA damage, particularly induction double-strand breaks. Using multiparameter cytometry we explored the effects doxorubicin (DOX), cisplatin (CDDP) and 5-fluorouracil (5-FU) on four types endometrioid adenocarcinoma cell lines (HEC-1A, HEC-1B, Ishikawa, KLE) correlating drug-induced increases in phosphorylated with cycle phase, apoptosis senescence, latter detected by analysis beta-galactosidase. The study revealed significant...
Abstract Strain relaxation in a GaInN/GaN heterostructure is analyzed by combining situ X‐ray diffraction (XRD) monitoring and ex observations. Two different characteristic thicknesses of GaInN films are defined the evolution XRD from full width at half‐maximum symmetric (0002) as function thickness. This measurement enables to clearly observe critical corresponding strain caused formation surface pits with bent threading dislocations generation misfit on during growth. (© 2013 WILEY‐VCH...
Aim Irinotecan-induced severe toxicities are possibly related to UGT1A1*6 and *28 genotypes. However, the correlation between UGT1A1 polymorphisms risk of induced by low-dose irinotecan plus platinum combination therapy still remains controversial. This prospective observational study aimed examine genotypes clinical outcomes (median 60 mg/m2, range 25–115 mg/m2) in Japanese patients with solid tumors. Methods Toxicity profiles were compared SNP heterozygotes (hetero-group) homozygous...
Two novel 23-fluorinated 25-hydroxyvitamin D3 analogues were synthesized using Inhoffen-Lythgoe diol as a precursor of the CD-ring, efficiently. Introduction C23 fluoro group was achieved by deoxy-fluorination reaction N,N-diethylaminosulfur trifluoride or 2-pyridinesulfonyl fluoride (PyFluor). Kinetic studies on CYP24A1-dependent metabolism these two revealed that (23S)-23-fluoro-25-hydroxyvitamin more resistant to than its 23R isomer.
The reaction of an alkylidene-bridged dithiolene complex, (η5-cyclopentadienyl){2-[(bis(methoxycarbonyl)methanido)thio-κC,κS]-1,2-bis(methoxycarbonyl)ethenethiolato-κS}cobalt(III), with trimethyl phosphite results in the formation a novel type sulfonium ylide coordinated to cobalt atom, (η5-cyclopentadienyl){2-[(bis(methoxycarbonyl)methylene)-λ4-thio-κS]-1,2-bis(methoxycarbonyl)ethenethiolato-κS}(trimethyl phosphite)cobalt(III). structure has been established by X-ray crystallographic analysis.