A5080968515- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Chromosomal and Genetic Variations
- Circular RNAs in diseases
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
University of Freiburg
2017-2018
Technical University of Munich
2016
Deep sequencing techniques and advanced data analysis methods recently enabled the characterization of thousands circular RNA isoforms (circRNAs) from a number tissues organisms. There is emerging evidence that some circRNAs may have important biological functions or serve as diagnostic biomarkers in disease conditions. In order to analyze circRNA expression heart its changes different conditions we performed RNA-Seq ribosome-depleted libraries rats (neonatal adult), mice (sham after...
Galaxy HiCExplorer is a web server that facilitates the study of 3D conformation chromatin by allowing Hi-C data processing, analysis and visualization. With server, users with little bioinformatic background can perform every step in one workflow: mapping raw sequence data, creation contact matrices, quality assessment, correction matrices identification topological associated domains (TADs) A/B compartments. Users create publication ready plots matrix, compartments, TADs on selected...
Storage of chromatin in restricted nuclear space requires dense packing while ensuring DNA accessibility. Thus, different layers organization and epigenetic control mechanisms exist. Genome-wide interaction maps revealed large domains (TADs) higher order A B compartments, reflecting active inactive chromatin, respectively. The mutual dependencies between patterns marks, including methylation, remain poorly understood. Here, we demonstrate that establishment A/B compartments precedes defines...