A5040379192- Lipid Membrane Structure and Behavior
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Cellular transport and secretion
- Trypanosoma species research and implications
- Diffusion and Search Dynamics
- Research on Leishmaniasis Studies
- Virology and Viral Diseases
- Parasites and Host Interactions
- Epigenetics and DNA Methylation
- Viral Infections and Outbreaks Research
- Nuclear Structure and Function
- DNA Repair Mechanisms
- Malaria Research and Control
- Genomics and Chromatin Dynamics
- Calcium signaling and nucleotide metabolism
University of North Carolina at Chapel Hill
2017-2024
University of Maryland, Baltimore
2012
Centre d’Immunologie de Marseille-Luminy
1988
The aim of this work was to determine whether human resistance Schistosoma mansoni associated with increased antibody reactivity certain larval surface Ag. To end, young residents a hyperendemic area were selected for their low or high susceptibility reinfection after parasitologic cure, and the sera individual Ag determined at different times before treatment. data showed that six Ag: 202, 165, 90 92, 85, 72, 37 kDa are principal targets on larva IgG in resistant subjects. comparative...
Zika virus (ZIKV) is a flavivirus that structurally highly similar to the related viruses, dengue (DENV), West Nile virus, and yellow fever virus. ZIKV causes an acute infection often results in mild symptoms but can cause severe disease rare instances. Following infection, individuals mount adaptive immune response, composed of antibodies (Abs) target envelope (E) glycoprotein ZIKV, which covers surface Groups have studied monoclonal polyclonal sera isolated from who recovered natural...
Dengue vaccine trials have revealed deficits in our understanding of the mechanisms protective immunity, demonstrating a need to measure epitope-specific antibody responses against each DENV serotype. HmAb 5J7 binds complex, 3-monomer spanning quaternary epitope DENV3 envelope (E) protein, but it is unclear whether all interactions are needed for neutralization. Structure guided design and reverse genetics were used sequentially transplant larger portions DENV3-specific mAb into dengue virus...
Adaptor protein complex-3 (AP-3) mediates cargo sorting from endosomes to lysosomes and lysosome-related organelles. Recently, it was shown that AP-3 adopts a constitutively open conformation compared the related AP-1 AP-2 coat complexes, which are inactive until undergoing large conformational changes upon membrane recruitment. How is regulated therefore an question. To understand mechanism of recruitment activation, we reconstituted human determined multiple structures in soluble...
Adaptor protein complex 3 (AP-3) mediates cargo sorting from endosomes to lysosomes and lysosome-related organelles. Recently, it was shown that AP-3 is in a constitutively open, active conformation compared the related AP-1 AP-2 coat complexes, which are inactive until undergoing large conformational changes upon membrane recruitment. How regulated therefore an open question. To understand mechanism of recruitment activation, we reconstituted core human determined multiple structures...