A5001935373- Nanoparticles: synthesis and applications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- RNA Interference and Gene Delivery
- Hemoglobin structure and function
- Phytochemistry and Bioactivity Studies
- Hemostasis and retained surgical items
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Medicinal Plants and Neuroprotection
- Nanoplatforms for cancer theranostics
- Ammonia Synthesis and Nitrogen Reduction
- Biological Stains and Phytochemicals
- Trauma and Emergency Care Studies
- Endoplasmic Reticulum Stress and Disease
- Blood transfusion and management
- Graphene and Nanomaterials Applications
- Abdominal Trauma and Injuries
- Nanotechnology research and applications
- Muscle and Compartmental Disorders
Waseda University
2019-2024
Muroran Institute of Technology
1999
Biogenic nanoparticles are the smartest weapons to deal with multidrug-resistant "superbugs" because of their broad-spectrum antibacterial propensity as well excellent biocompatibility. The aqueous biogenic silver (Aq-bAgNPs) and ethanolic (Et-bAgNPs) were synthesized using extracts Andrographis paniculata stem, respectively, reducing agents. Electron microscopic images confirmed synthesis almost spherical shaped (bAgNPs). zeta potentials negative -22 -26 mV for Aq-bAgNPs Et-bAgNPs,...
BACKGROUND We previously developed substitutes for red blood cells (RBCs) and platelets (PLTs) transfusion. These included hemoglobin vesicles (HbVs) fibrinogen γ‐chain (dodecapeptide HHLGGAKQAGDV, H12)–coated, adenosine diphosphate (ADP)‐encapsulated liposomes [H12‐(ADP)‐liposomes]. Here, we examined the efficacy of combination therapy using these instead RBC PLT transfusion in a rabbit model with trauma‐induced massive hemorrhage coagulopathy. STUDY DESIGN AND METHODS Thrombocytopenia (PLT...
Nanotherapeutics has emerged as the most sought after approach to tackle menace of drug-resistant pathogenic bacteria. Among others, biogenic silver nanoparticles (bAgNPs) synthesized using medicinal plant extracts demonstrate promising antibacterial propensity with excellent biocompatibility. Herein, bAgNPs were through green chemistry Syzygium cymosum leaf extract a reducing agent at different pH values (i.e., 5, 7, 8, and 10). The average size 10 was 23.3, 21.3, 17.2, 35.3 nm,...
Among metallic nanoparticles, silver nanoparticles (AgNPs) have a wide spectrum of medical applications. Herein, biogenic (bAgNPs) were prepared from extracts Caesalpinia digyna leaf as reducing agent at different pH values (i.e., 5, 7, 8, and 10). The as-synthesized bAgNPs characterized using UV-vis Fourier transform infrared (FTIR) spectroscopies, scanning transmission electron microscopy, powder X-ray diffraction analysis, dynamic light scattering, ζ-potential analysis. sizes 10 45.4,...
The application of nanotherapeutics is being considered as one the most sought-after strategies to combat threat posed by drug resistant bacteria.
Aim: The uptake pathway of liposomes into cells is mainly via endocytosis or membrane fusion; however, the relationship between and intracellular pharmacokinetics liposome components remains unclear. This study aimed at revealing by using cationic having similar physical properties different pathways. Materials Methods: We prepared composed amino acid-type lipids, K3C14 K3C16, which have pathways a hydration method, fluorescently modified them encapsulating FITC-dextran surface conjugation...
Biogenic silver nanoparticles demonstrate excellent antibacterial activity against a broad range of bacteria. Herein, aqueous biogenic (Aq@bAgNPs) and ethanolic (Et@bAgNPs) were synthesized using as well extracts Diospyros malabarica fruit, respectively. The as-prepared (bAgNPs) characterized UV-Vis, FTIR energy dispersive X-ray (EDS) spectroscopy, electron microscopy, dynamic light scattering spectroscopy (DLS), zetasizer. zeta potentials Aq@bAgNPs Et@bAgNPs −9.8 ± 2.6, −12.2 1.9 mV, bAgNPs...
Fibrinogen γ-chain peptide-coated, adenosine 5'-diphosphate (ADP)-encapsulated liposomes (H12-ADP-liposomes) are a potent haemostatic adjuvant to promote platelet thrombi. These lipid particles coated with specific binding sites for GPIIb/IIIa and encapsulating ADP. They work at bleeding sites, facilitating haemostasis by promoting aggregation of activated platelets releasing ADP strongly activate platelets. In this study, we investigated the therapeutic potential H12-ADP-liposomes on...
Bioactive peptides, which act as biologically active regulators, often require intracellular delivery systems to access their therapeutic targets in the cytosolic space maintaining bioactivity. Here, we report on of a polar cell impermeable bioactive peptide, phalloidin, into living HeLa cells with cationic liposomes prepared from lysine-based lipids. Liposome/Alexa Fluor 594 phalloidin complexes were characterized regarding size and zeta potential, 85 ± 38 nm +24.5 4.21 mV, respectively....
Damage control resuscitation improves patient outcomes after severe hemorrhage and coagulopathy. However, effective hemostasis methods for these critical situations are lacking.
It is well-known that iron one of the most common impurity elements observed in industrial aluminum. Iron aluminum forms an intermetallic compound such as FeAl3. The FeAl3 exposed on matrix are detrimental to corrosion. A simple and effective electrochemical treatment, by which selective removal can proceed, has been developed with a number trials. found FeAl3-free surface obtained treatments 17 mass%HNO3 solution. explained treatment attributes two operations; activation H2, N2O, NO NO2 gas...
Event Abstract Back to Transfusion with synthetic platelet substitutes, H12-(ADP)liposomes, effectively rescues thrombocytopenic rabbits from massive hemorrhage Masato Takikawa1, Kosuke Hagisawa2, Manabu Kinoshita3, Haruka Asahina4, Daizo Saito5 and Shinji Takeoka1 1 Waseda University, Graduate School of Advanced Science Engineering, Japan 2 National Defense Medical College, Department Physiology, 3 Immunology Microbioogy, 4 Traumatology Critical Care Medicine, 5 College Research Institute,...