A5042657556- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- HIV Research and Treatment
- HIV/AIDS Impact and Responses
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Cervical Cancer and HPV Research
- HIV-related health complications and treatments
- Mobile Health and mHealth Applications
- Hepatitis B Virus Studies
- Water Quality and Pollution Assessment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Public-Private Partnership Projects
- Data-Driven Disease Surveillance
- Neurological and metabolic disorders
- Water resources management and optimization
- Tuberculosis Research and Epidemiology
- Parvovirus B19 Infection Studies
- Electrolyte and hormonal disorders
- Reproductive tract infections research
- Reproductive Health and Contraception
- Infant Health and Development
- ICT in Developing Communities
- Biometric Identification and Security
- Adolescent and Pediatric Healthcare
Kenyatta National Hospital
2011-2023
Triangle
2013
Family Health International 360
2013
University of Nairobi
2010-2011
Data to inform the switch from a ritonavir-boosted protease inhibitor (PI) dolutegravir in patients living with human immunodeficiency virus (HIV) infection who do not have genotype information and viral suppression second-line therapy containing PI been limited. Download PDF of Research Summary. In prospective, multicenter, open-label trial conducted at four sites Kenya, we randomly assigned, 1:1 ratio, previously treated without had while receiving treatment either or continue current...
Background Intrapartum and neonatal single-dose nevirapine (NVP) reduces the risk of mother-to-child HIV transmission but also induces viral resistance to non-nucleoside reverse transcriptase inhibitor (NNRTI) drugs. This drug largely fades over time. We hypothesized that women with a prior NVP exposure would have no more than 10% higher cumulative prevalence failure their NNRTI-containing antiretroviral therapy (ART) first 48 wk without exposure. Methods Findings enrolled 355 NVP-exposed...
Abstract Background Tuberculosis (TB) is the most common opportunistic infection and leading cause of death in people living with HIV (PLHIV). HIV-infected children are at a higher risk TB disease compared to those without HIV. Isoniazid preventive therapy (IPT) an effective intervention preventing progression latent active TB. The World Health Organization (WHO) currently recommends that all aged > 12 months adults whom has been excluded should receive 6-months course IPT as part...
Background: Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) remains a great challenge among young people in Kenya. Young living with HIV are faced lot of challenges that often overlooked and may have an impact on their treatment adherence overall well-being. This calls for interventions age-appropriate, which tap into the psychosocial problems they experience. is protocol proposed study aimed at developing facilitator-led peer support manual called ‘Positive...
Early mortality rates after initiating antiretroviral therapy (ART) are high in sub-Saharan Africa. We examined whether serum chemistries at ART initiation predicted among HIV-infected women. From May 2005 to January 2007, we enrolled women a prospective cohort study Zambia and Kenya. used Cox proportional hazards models identify risk factors associated with mortality. Among 661 women, 53 (8%) died during the first year of ART, tuberculosis was most common cause death (32%). Women were more...
Background: Cervical cancer is the commonest cause of cancer-related morbidity and mortality among women in developing countries sub-Saharan Africa. Screening for cervical HIV infected crucial as they are more at risk disease progressing faster once with Human Papilloma Virus (HPV).Methods: We aimed to determine factors affecting utilization screening above 18 years age Kenyatta National Hospital by conducting a cross-sectional mixed quantitative qualitative methods study. Descriptive...
Clinical trials were conducted to assess the feasibility of using a cell phone text messaging-based system follow up Human Immunodeficiency Virus (HIV) infected patients on antiretroviral (ARTs) and for improved adherence their medication. However there is need evaluate perceptions HIV towards use these phones in an effort better aid clinical management infection. The objective this study was therefore determine messaging as tool support ART medication.A cross sectional survey among...
Objective Hypertension affects 23% of Kenyans and is the most prevalent modifiable risk factor for cardiovascular disease. Despite this, hypertension awareness treatment adherence very low. We conducted a qualitative study to explore lay beliefs about among HIV-infected adults inform development culture sensitive prevention control program. Methods Eight focus group discussions were held 53 at HIV clinic in Kenya. Results Respondents had difficulties describing hypertension. was considered...
Abstract Collecting self-reported data on adherence to highly active antiretroviral therapy (HAART) can be complicated by patients' reluctance report poor adherence. The timeliness with which patients attend visits might a useful alternative estimate medication Among Kenyan and Zambian women receiving twice daily HAART, we examined the relationship between pill taking attending scheduled visits. We analyzed from 566 enrolled in prospective 48-week HAART-response study. At each clinic visit,...
Abstract Background CCR5 antagonists have clinically been approved for prevention or treatment of HIV/AIDS. Countries in Sub-Saharan Africa with the highest burden HIV/AIDS are due to adopt these regimens. However, HIV-1 can also use CXCR4 as a co-receptor. There is hence an urgent need map out cellular tropism country’s circulating HIV strains guide impending antagonists. Objectives To determine coreceptor usage among patients attending comprehensive care centre Nairobi, Kenya. Methods...
Background: Women’s knowledge and access to reproductive health services improves their ability safely achieve required fertility reduces maternal infant morbidity mortality. We aimed determine the utilization of family planning (FP) among HIV Infected women visiting clinic.Methods: A cross-sectional mixed quantitative qualitative study positive females in Nairobi, Kenya was conducted. Consenting completed a questionnaire that assessed FP services. Descriptive inferential analysis carried...
Introduction Simultaneous use of contraceptive hormones and anti‐retroviral therapy (ART) may theoretically lessen the effectiveness both. Women on ART need assurance that hormonal contraception is safe effective. The sub‐dermal implant an ideal product to study: low steady progestin release no adherence uncertainties. We sought determine if medications’ compromised. Methods conducted a prospective cohort study among women first line (stavudine or zidovudine lamivudine+nevirapine). recruited...
Background: In 2009, Kenyatta National Hospital (KNH) integrated cervical cancer screening within HIV care using visual inspection with acetic acid (VIA) and Pap smear cytology.Objectives: We evaluated utilisation of human papillomavirus (HPV) vaccination among women living (WLHIV) receiving at KNH.Method: From November 2019 to February 2020, WLHIV aged ≥ 14 years were invited participate in a survey following receipt routine services. assessed awareness cancer, uptake screening, the HPV...
Understanding trends in patient profiles and identifying predictors for adverse outcomes are key to improving the effectiveness of HIV care treatment programs. Previous work Kenya has documented findings from a rural setting. This paper describes demographic clinical characteristics antiretroviral therapy (ART) cohorts at large urban, referral clinic explores factors associated with attrition during 12 years follow-up.This was retrospective cohort analysis HIV-infected adults who started ART...
Welcome to Annals of Global Health,Annals Health is a peer-reviewed, fully open access, online journal dedicated publishing high quality articles all aspects global health. The journal's mission advance health, promote research, and foster the prevention treatment disease worldwide. Its goals are improve health well-being people, equity, wise stewardship earth's environment. latest impact factor 3.64.Annals supported by Program for Public Common Good at Boston College. It was founded in 1934...
Lack of appropriate follow-up HIV Exposed Infants (HEIs) after delivery contributes to suboptimal access and uptake Early Infant Diagnosis (EID) interventions. This could result in unidentified HEIs potentially HIV-infected infants who are at risk morbidity mortality where interventions such as Anti-Retroviral Therapy (ART) not commenced. Biometric identification has been used successfully increase immunization coverage. study investigated the feasibility acceptability using biometrics for...
Human immunodeficiency virus-serodiscordant couples are an important source of new HIV infections in Africa. When trying to conceive, uninfected partners may be at high risk infection if the infected partner is not virally suppressed. Multiple strategies targeting safer conception exist, but these services limited. However, when available and used, serodiscordant can protected from transmission, safe have children desired. To successfully introduce, integrate, promote, optimize service...
The success of antiretroviral therapy in resource-scarce settings is an illustration that complex healthcare interventions can be successfully delivered even fragile health systems. Documenting the factors scale-up HIV care and treatment resource constrained will enable systems to prepare for changing population needs. This study describes demographic clinical characteristics adult pre-ART cohorts, identifies predictors attrition at a large urban clinic Nairobi, Kenya.We conducted...
Background: Limited data is available on the treatment outcomes of HIV infected adolescents and young adults (AYA) in sub-Saharan Africa. HIV-infected are at high risk developing antiretroviral failure.
 Objective: To determine clinical, immunological virologic AYA a tertiary hospital Kenya.
 Methodology: A longitudinal study was conducted among age 10-24 years attending Kenyatta National Hospital comprehensive care center. Clinical abstracted from electronic medical records for...