A5082404594- Pancreatic function and diabetes
- Genetics and Neurodevelopmental Disorders
- Diabetes and associated disorders
- Prosthetics and Rehabilitation Robotics
- Diabetes Management and Research
- Biomedical Ethics and Regulation
- Metabolism, Diabetes, and Cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Phagocytosis and Immune Regulation
- Robotic Locomotion and Control
- Biomedical and Engineering Education
- Protein Degradation and Inhibitors
- Organ and Tissue Transplantation Research
- Electrical Fault Detection and Protection
- Pluripotent Stem Cells Research
- Anatomy and Medical Technology
- Extracellular vesicles in disease
- Stroke Rehabilitation and Recovery
- Media Influence and Politics
- Epigenetics and DNA Methylation
- Fire effects on concrete materials
- Structural Response to Dynamic Loads
- Additive Manufacturing and 3D Printing Technologies
- Xenotransplantation and immune response
- CRISPR and Genetic Engineering
Embry–Riddle Aeronautical University
2022-2024
Lehigh University
2024
Columbia University
2018-2022
Columbia University Irving Medical Center
2018-2022
Dartmouth College
2019
University of Lausanne
2018
Glucagon-like peptide-1 receptor (GLP1R) agonists and dipeptidyl peptidase 4 inhibitors are widely prescribed diabetes drugs due to their ability stimulate insulin secretion from remaining β cells reduce caloric intake. Unfortunately, they fail increase human cell proliferation. Small-molecule of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) able induce adult proliferation, but rates modest (~2%), specificity is limited. Here, we provide evidence that combining any member the GLP1R...
The double bromodomain and extra-terminal domain (BET) proteins are critical epigenetic readers that bind to acetylated histones in chromatin regulate transcriptional activity modulate changes structure organization. testis-specific BET member, BRDT, is essential for the normal progression of spermatogenesis as mutations Brdt gene result complete male sterility. Although BRDT expressed both spermatocytes spermatids, loss first leads severe defects spermiogenesis without overtly compromising...
Abstract Mutations in HNF1A cause Maturity Onset Diabetes of the Young (HNF1A-MODY). To understand mechanisms β-cell dysfunction, we generated stem cell-derived pancreatic endocrine cells with hypomorphic mutations HNF1 A. HNF1A- deficient β-cells display impaired basal and glucose stimulated-insulin secretion, reduced intracellular calcium levels association a reduction CACNA1A expression, accumulation abnormal insulin granules SYT13 down-regulation. Knockout reproduce relevant phenotypes....
Diabetic β cell failure is associated with dedifferentiation. To identify effector genes of dedifferentiation, we integrated analyses histone methylation as a surrogate gene activation status and RNA expression in cells sorted from mice multiparity-induced diabetes. Interestingly, only narrow subset demonstrated concordant changes to levels dedifferentiating cells. Notable among them was the α signature Gc, encoding vitamin D-binding protein. While diabetes Gc induction, Gc-deficient islets...
Abstract Mutations in HNF1A cause Maturity Onset Diabetes of the Young type 3 (MODY3), most prevalent form monogenic diabetes. We generated stem cell-derived pancreatic endocrine cells from human embryonic (hESCs) with induced hypomorphic mutations . Using these cells, we show that orchestrates a transcriptional program required for distinct aspects β-cell fate and function. During islet cell differentiation, deficiency biases towards an α -cell associated PAX4 down-regulation. HNF1A-...
Humans have a remarkable ability to infer and represent others’ mental states such as their beliefs, goals, desires, intentions, feelings. In this chapter, we review some of the innovations that developed in economics, computer science, cognitive neuroscience modeling computations underlying several mentalizing operations. Broadly, involves building models how agents other within constrained environments. These include modules for: representing goals desires an agent (e.g., maximize reward,...
With biped and quadruped robots becoming more prevalent in society, there is a strong push for universities to update their robotics curriculum teach students how design, build, program legged robotic systems. One of the challenges associated with developing finding opportunities engage hands-on activities that complement theory enhance overall learning process. This challenge particularly evident at smaller or limited research budgets where cost purchasing platform can be prohibitive....
Abstract Additive manufacturing technologies have become increasingly prevalent in recent years and, with their abundance, opened many doors the field of and design. The medicine has always been high demand for new techniques to create medical prostheses, devices, trainers. With this increased need, 3D printing obvious solution, it, a major problem arisen. lack material property data on filament post extrusion leaves designers engineers having perform extraneous tests accurate models. This...
Abstract Mutations in HNF1A cause Maturity Onset Diabetes of the Young type 3 (MODY3), most prevalent form monogenic diabetes. Using stem cell-derived pancreatic endocrine cells from human embryonic (hESCs) with induced hypomorphic mutations HNF1A, we show that orchestrates a transcriptional program required for calcium-dependent insulin secretion. HNF1A-deficient β-cells display reduction CACNA1A and intracellular calcium levels, as well impaired granule exocytosis association SYT13...