A5055006595- Autophagy in Disease and Therapy
- Streptococcal Infections and Treatments
- Inflammasome and immune disorders
- Cancer Diagnosis and Treatment
- Oral microbiology and periodontitis research
- Neurofibromatosis and Schwannoma Cases
- PARP inhibition in cancer therapy
- Sympathectomy and Hyperhidrosis Treatments
- Caveolin-1 and cellular processes
- Gastrointestinal Tumor Research and Treatment
- Oral and gingival health research
- Adipose Tissue and Metabolism
- Insect and Arachnid Ecology and Behavior
- Oral and Maxillofacial Pathology
- Facial Nerve Paralysis Treatment and Research
- Adenosine and Purinergic Signaling
- Glioma Diagnosis and Treatment
- Hemiptera Insect Studies
- Salivary Gland Disorders and Functions
- Immune Response and Inflammation
- Oral health in cancer treatment
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Toxoplasma gondii Research Studies
- Toxin Mechanisms and Immunotoxins
Nippon Dental University
2018-2025
Yokohama City University
1990-2025
California Institute of Technology
2025
Kyoto University
2017
Hyogo University of Health Sciences
2017
Jikei University School of Medicine
2012
Kanagawa Rehabilitation Hospital
1986
Abstract Invading microbial pathogens can be eliminated selectively by xenophagy. Ubiquitin-mediated autophagy receptors are phosphorylated TANK-binding kinase 1 (TBK1) and recruited to ubiquitinated bacteria facilitate autophagosome formation during xenophagy, but the molecular mechanism underlying TBK1 activation in response infection is not clear. Here, we show that bacterial increases Ca 2+ levels activate for xenophagy via -binding protein TBC1 domain family member 9 (TBC1D9)....
This study aimed to identify periodontal pathogens involved in the onset and progression of OSCC. Saliva samples were collected from 112 patients without oral mucosal diseases (OMDs) as controls; 36 with potentially malignant disorders (OPMDs); 104 Periodontal examinations performed on all patients. Endpoint PCR was for seven species pathogens. The 16S rRNA analysis using 20 DNA each group. Periodontitis tended worsen OMDs group compared control number bacteria significantly higher OSCC than...
A rare case of congenital insensitivity to pain with anhidrosis is presented. The male patient, who expired at 17 years age, was noted insensitive and bouts unexplained fever birth. He frequently fractured the hands feet secondary osteomyelitis. did not sweat even in warm season. intradermal nerve fibres glands were normal distribution. peripheral seemed be almost light microscopy but electron microscopical study revealed extreme paucity unmyelinated fibers a reduction myelinated fibres,...
Group A Streptococcus (GAS) can invade epithelial cells; however, these bacteria are targeted and eventually destroyed by autophagy. Members of the Nod-like receptor (NLR) family thought to be critical for autophagic response invasive bacteria. However, intracellular sensors within host cells that responsible bacterial invasion induction autophagy largely unknown. Thus, our aim was examine role one such NLR, namely NLRX1, in during GAS infection. We found markedly increased NLRX1 knockout...
Autophagy selectively targets invading bacteria to defend cells, whereas bacterial pathogens counteract autophagy survive in cells. The initiation of canonical involves the PIK3C3 complex, but targeting Group A Streptococcus (GAS) is PIK3C3-independent. We report that GAS infection elicits both PIK3C3-dependent and -independent autophagy, effector NAD-glycohydrolase (Nga) modulates autophagy. regulates starvation-induced (canonical) by secreting streptolysin O Nga, Nga also suppresses...
Anti-apoptotic Bcl-2 and Bcl-xL are proposed to regulate starvation-induced autophagy by directly interacting with Beclin 1. 1 is also thought be involved in multiple vesicle trafficking pathways such as endocytosis binding Atg14L UVRAG. However, how the interaction of family proteins regulates anti-bacterial (xenophagy) still unclear. In this study, we analyzed these interactions using Group A Streptococcus (GAS; pyogenes) infection a model. GAS internalized into epithelial cells through...
SIRT6 is one of seven human sirtuin genes and known to act as an onco-suppressor gene in colorectal ovarian cancers, although it up-regulated other cancers. Thus, considered performing both tumor-suppressing promoting roles. However, the association with oral squamous cell carcinoma (OSCC) its role OSCC pathogenesis currently unclear. This study aimed investigate expression patients potential a biomarker for early detection prognosis prediction.Immunohistochemistry, quantitative real-time...
Group A Streptococcus (GAS) invades into epithelial cells for persistent infection. GAS has a variety of effector proteins that modulate host systems their survival in environments. The main are NAD-glycohydrolase (Nga) and streptolysin O (SLO). Although Nga NADase activity shows SLO-dependent cytotoxicity, some clinical isolates harbor NADase-inactive subtypes Nga, the function is still unclear. In this study, we found deletion nga enhanced internalization HeLa Ca9-22 cells. Amino acid...
Background/Aim: Treatment failure in oral cancer is mainly caused by uncontrolled cervical lymph node (LN) metastasis. We previously reported that CD11b+ cells are recruited into tumor hypoxic areas following radiation, leading to re-vascularization and relapse. Since lymphatic vessel formation has similarities with vascular formation, we examined whether surgery induces hypoxia stimulates lymphangiogenesis. Materials Methods: The recruitment of the vessels were using orthotopic tongue mouse...
症例は72歳の女性で，心窩部痛と嘔気を主訴に当院を受診した．下腹部に圧痛を伴う可動性腫瘤を触知し，腹部CTで骨盤内に約10cm大の分葉状腫瘍を認め，巨大腹腔内腫瘍の診断で入院した．腹部造影CTとMRIで上腸間膜動脈を軸にした小腸捻転と小腸gastrointestinal stromal tumor（以下，GISTと略記）の疑いと診断し待機的に手術を行った．トライツ靭帯から100cm肛門側空腸に壁外発育性の分葉状腫瘍を認め，腫瘍は茎部で約180度捻転していた．また小腸は腸間膜起始部で時計方向に約270度軸捻転していたが虚血は認めず，腫瘍を含めた空腸部分切除を施行した．病理組織学的検査の結果，high-grade malignancyの空腸GISTと診断した．小腸GISTによる小腸軸捻転の報告は散見されるが，検索した範囲でGIST自体の茎捻転を伴った報告は過去になく，非常にまれな病態であり報告した．
由として，脳転移症例の多くは多発転移であり根治が難しい点や，脳脊髄関門の存在によって化学療法 の効果が他臓器転移と比べ低いことなどが挙げられる．今回，我々は孤立性脳転移を契機に発見された S 状結腸癌の症例に対し，両者を外科的切除して長期予後を得た症例を経験したので報告する． 症 例 症例：54 歳，女性． 主訴：頭痛・右上下肢のしびれと脱力 家族歴：特記すべき事項なし． 既往歴：特記すべき事項なし． 現病歴：2005 年 11 月に頭痛と右上下肢のしびれ・脱力を訴え，当院脳神経外科を受診した． 入院時現症：右上下肢の筋力低下を認め，自立歩行は困難であった．腹部は平坦・軟で，直腸肛門診 で腫瘤を触知しなかった．緩下剤等使用せずに 1 日 回以上の排便が得られていた． 血液検査所見：血算で異常を認めず，生化学検査で CEA：2.8ng! ml，SCC：0.3ng! ml と正常，CA19-9：58U!ml と軽度上昇していた． 頭部 MRI：左前頭葉に直径 15mm 大の分葉状の腫瘍を認め T1 強調にて iso-intencity， T2 強調にて辺 縁が high，内部が...
Abstract Background: Bacterial and virus infection may cause pre-malignant malignant disorder such as hepatocellular carcinoma cervical cancer. Recent studies reported that oral bacterium is associated with gastric colon However, it not clear yet if the microbiome affects development of in cavity Thus, this study aims to identify periodontal pathogen candidates involved onset progression squamous cell (OSCC). Materials Methods: Saliva was collected from 112 patients without mucosal diseases...
直腸癌患者56例に経直腸超音波検査を行い, 56例中転移陽性28例中の15例, 転移陰性28例中の4例に旁直腸リンパ節が描出できた.56例の手術標本から得た791個の旁直腸リンパ節の大きさとリンパ節内に占める転移の範囲と, 描出の有無を検討してみると, 転移陽性のリンパ節の20%転移陰性のリンパ節の0.7%が描出され (P<0.01), 転移陽性のものでは転移組織がリンパ節の半分以上を占める4mm以上のリンパ節が描出され, また転移陰性でも大型のリンパ節には描出されたものがあった.しかし画像上からは転移の有無を区別できなかった.寒天で作成したリンパ節の模型を用いると球状のものは偏平なものに比べ描出されやすく, また転移組織がリンパ節の半分以上を占めるリンパ節の多くは球状で, 転移が小範囲のものや陰性のものは偏平なものが多かった.球状に腫大したリンパ節が描出されやすいと思われた.