Abstract Background Self-medication is defined as using medicinal products to treat the disorders or symptoms diagnosed by oneself. Although informed self-medication one of ways reduce health care costs, inappropriate self-treatment can pose various risks including drug side effects, recurrence symptoms, resistance, etc. The purpose this study was investigate knowledge, attitude, and practice pharmacy medical students toward self-medication. Methods This conducted in Zabol University Medical...

Aim This study was conducted to evaluate the effect of prebiotics on some common clinical ailments in healthy term infants. Methods Sixty healthy‐term, breastfed (BF) infants were included. Along with these infants, 120 healthy‐term formula‐fed randomly assigned either prebiotic formula (PF, n = 60) or regular (RF, groups. Ready‐to‐use prebiotic‐supplemented containing galacto‐oligosaccharides and polydextrose (ratio 1:1) used. Results At 2 months age, PF demonstrated significantly higher...

Umbelliprenin (UMB) has shown various pharmacological properties in vitro. We investigated the antineoplastic and immunostimulatory effects of UMB 4T1 mammary‐tumor‐bearing mice. Two‐hundred microliter (12.5 mg/ml) was intraperitoneally administrated to healthy tumor‐bearing female Balb/c mice for a period 18 days. Data analyzed using GraphPad Prism 5 software Windows (version 5, La Jolla, CA). caused significant decrease tumor size ( P < 0.01). Serum interferon gamma (IFNγ) augmented...

Low quality of life (QOL) is a feature that has been overlooked in thalassemia major (TM) patients. Our aim was to assess QOL school-aged TM patients Zabol city and surrounding rural areas southeast Iran. The study performed 2014. evaluated using Pediatric Quality Life Inventory 4 (PedsQL4) questionnaire addressing physical, emotional, social, educational, along with psychological health 80 Also, age-matched sex-matched subjects without any chronic illness served as control group. Mean age...

Glioblastoma is the most common malignant brain tumor representing with poor prognosis, therapy resistance and high metastasis rate. Increased expression activity of matrix metalloproteinase-2, a member metalloproteinase family proteins, has been reported in many cancers including glioblastoma. Inhibition metalloproteinase-2 resulted reduced aggression glioblastoma tumors several reports. In present study, we evaluated effect bee venom on as well potential toxicity apoptogenic properties...

Hypothyroidism (HT) and hypoparathyroidism (HPT) are common endocrine complications in thalassemia major (TM) patients.In the present study, we assessed frequency of HT HPT a population TM patients Southeast Iran.This cross sectional study was performed on 194 Zabol, Sistan Baluchestan Province, Iran, during February - July 2016. The demographic, clinical, laboratory data were collected via interviews history taking. For hormone measurements, specific ELISA kits used. Statistical analysis...

Introduction: Diabetes Mellitus (DM) represents a major con cern in Thalassaemia Major (TM) patients.Aim: The present study was conducted to evaluate the frequency of Impaired Fasting Glucose (IFG) and DM TM patients Southeast Iran. Materials Methods:Fasting Blood (FBS) determined using fasting blood samples 148 patients.Demographical data collected by questionnaire.Clinical laboratory variables including cell counts, pre transfusion Haemoglobin (Hb) level, fiveyear ferritin were extracted...

Our aim was to investigate the effects of resveratrol, auraptene, and curcumin on spatial learning memory retention in Morris water maze (MWM). The 4-day bilateral intrahippocampal (i.h.) infusions dimethyl sulfoxide (DMSO), H-89 as a protein kinase AII inhibitor, auraptene/H-89, resveratrol/H-89, curcumin/H-89 were investigated acquisition MWM. rats trained for 4 days; each day included one block four trials. Post-training probe tests performed 5 test. For assessments, different animals...

Abstract The antineoplastic effects of 5‐hydroxytryptamine (5‐HT) receptor antagonists have been shown in previous studies. However, the exact underlying mechanisms mediating these are unclear. In present study, we assessed tropisetron, a 5‐HT antagonist, an experimental model lung cancer BALB/c mouse. Lewis carcinoma cell line was used to induce cancer. Mice were divided into four groups (n = 6) as follows: tumor‐bearing mice + tropisetron (5 mg/kg intraperitoneally [IP]), (10 IP), saline,...

Burn survivors experience profound physiological changes following injury, which may have lasting implications for cardiovascular health. This study aims to investigate the risk profile among burn treated at a center in northern Iran. observational was conducted from 2022 2023 centre affiliated with Guilan University of Medical Sciences, Rasht, assessed cohort 210 survivors, focusing on individuals ≥20% TBSA injuries who had recovered and returned their daily lives. patients' lipid profiles,...

Recently, it has been revealed that tyrosine kinase inhibitors (TKIs) act through inducing both oxidative and endoplasmic reticulum (ER) stress in chronic myeloid leukemia cells. However, ER signaling triggers apoptotic survival processes within Nevertheless, mechanisms by which TKIs avoid the pro-survival effects are not clear. The aim of this study was to evaluate potential role activity unfolded protein response (UPR) pathway K562 cell line.The expression UPR target genes, Xbp1, Grp94...

Inheritance of mild mutations within the β-globin gene and coinheritance α-thalassemia (α-thal) are known as two important genetic modifiers in β-thalassemia (β-thal) intermedia (β-TI). We aimed to evaluate spectrum β- α-thal β-TI patients Southeast Iran. Common α-globin were detected by amplification refractory mutation system–polymerase chain reaction (ARMS–PCR) multiplex gap-PCR, respectively. There 26 male (57.8%) 19 female (42.2%) patients. HBB: c.92 + 5T > C [IVS-I-5 (G C)] c.−138C 1G...

The 5, 10-methyleneterahydrofolate reductase (MTHFR) and methionine synthase (MTRR) are two essential enzymes involved in folate metabolism. relationship between genetic polymorphisms congenital heart defects (CHDs) is inconsistent. Our aim was to investigate the association well-known of MTHFR MTRR genes, C677T A66G, respectively, CHDs Iranian patients.We enrolled 74 patients with ventricular septal defect (VSD) 79 tetralogy fallot (TOF) along 147 healthy controls. A66G were detected using...

Background: The role of genetic polymorphisms in genes Glutathione-S-transferases (GST) enzymes susceptibility to oral cavity cancers is controversial. Oral Squamous Cell Carcinoma (OSCC) the most common neoplasm. Aimed evaluate potential impacts two well-known null variants residing gene encoding GSTM1 and GSTT1 OSCC patients southeast Iran. Methods: In a case-control design, 113 individuals (50 patients, 63 healthy subjects) were included. DNA was extracted using paraffin-embedded tissues....

Background: Ursodeoxycholic acid (UDCA) is a safe drug used in the treatment of cholestatic liver disorders children. The aim this study was to investigate synergistic effect UDCA combination with phototherapy treating indirect neonatal hyperbilirubinemia. Methods: Present double-blinded, randomized clinical trial conducted among neonates jaundice who were under ward affiliated Zabol University Medical Sciences 2017. patients (200 neonates) randomly divided into intervention (phototherapy+...

Background: Hepatitis is a serious blood born infection in patients with β-thalassemia major (β-TM). There was no previous report on hepatitis prevalence β-TM Zabol, Iran. Objectives: The current study aimed to evaluate characteristics of ᵝ-TM visiting Imam Khomeini Hospital Sistan and Baluchistan province Iran. Patients Methods: were 90 ᵝ-TM. General demographic laboratory results obtained by interviews reviewing clinical histories. Data for anti-HCV, HBs antigen anti-HBs extracted from...