A5080555059- Computational Drug Discovery Methods
- Neuropeptides and Animal Physiology
- Healthcare and Venom Research
- Tissue Engineering and Regenerative Medicine
- Bee Products Chemical Analysis
- Pharmacological Effects of Natural Compounds
- CRISPR and Genetic Engineering
- Cancer, Stress, Anesthesia, and Immune Response
- Hepatitis B Virus Studies
- Diverse Scientific Research Studies
- Anesthesia and Pain Management
- Endoplasmic Reticulum Stress and Disease
- IL-33, ST2, and ILC Pathways
- Phytochemistry and Bioactivity Studies
- Natural Antidiabetic Agents Studies
- Extracellular vesicles in disease
- Scientific Computing and Data Management
- Mesenchymal stem cell research
- vaccines and immunoinformatics approaches
- Gut microbiota and health
- Nerve injury and regeneration
- Gastrointestinal motility and disorders
- Enzyme Structure and Function
- Research in Cotton Cultivation
- Synthesis and biological activity
Shiraz University of Medical Sciences
2020-2025
Yasuj University of Medical Sciences
2019
Mashhad University of Medical Sciences
2017
SARS-CoV-2 has caused millions of infections and more than 700,000 deaths. Taking the urgent need to find new therapeutics for coronavirus disease 2019 (COVID-19), a dataset plant-based natural compounds was selected screening antiviral activity. The viral 3-chymotrypsin-like cysteine protease (Mpro, 3CLpro) as target. Molecular docking performed on 2,845 phytochemicals estimate spatial affinity active sites enzyme. ADMET used pharmacological physicochemical properties hit compounds....
Airway remodeling, a hallmark of chronic obstructive pulmonary disease (COPD) and mustard lung disease, is influenced by the Trefoil Factor 3 (TFF3). This study sought to pinpoint compound with minimal toxicity that can effectively suppress TFF3 expression activity. We employed an integrative approach, combining gene analysis, molecular docking, dynamics simulations identify potential inhibitors. Gene analysis utilized Z-scores from Library Integrated Network-Based Cellular Signatures...
Glioblastoma is the most common malignant brain tumor representing with poor prognosis, therapy resistance and high metastasis rate. Increased expression activity of matrix metalloproteinase-2, a member metalloproteinase family proteins, has been reported in many cancers including glioblastoma. Inhibition metalloproteinase-2 resulted reduced aggression glioblastoma tumors several reports. In present study, we evaluated effect bee venom on as well potential toxicity apoptogenic properties...
Despite effective anticancer effects, the use of doxorubicin (DOX) is hindered due to its cardio and neurotoxicity. The neuroprotective effect adrenomedullin (AM) was shown in several studies. present study aimed evaluate possible protective effects AM against DOX-induced toxicity dorsal root ganglia (DRGs) neurons.Rat embryonic DRG neurons were isolated cultured. various concentrations DOX (0.0 100 µM) absence or presence (3.125 -100 nM) on cell death, apoptosis, oxidative stress,...
Aging causes numerous age-related diseases, leading the human species to death. Nevertheless, rejuvenating strategies based on cell epigenetic modifications are a possible approach counteract disease progression while getting old. Cell reprogramming of adult somatic cells toward pluripotency ought be promising tool for diseases. However, researchers do not have control over this process as lose their fate, and cause potential cancerous or unexpected phenotypes. Direct partial were introduced...
Substantial evidence indicates that exposure to extremely low frequency-electromagnetic fields (ELF-EMFs) affects male reproductive system.
The Covid-19 pandemic is new challenge all around the world. This provides an emergency development of vaccines and drugs against this virus. As main proteases CoV-19 have essential roles in transmission virulence virus. So, enzyme has been considered as a critical target to inhibit COVID-19. Natural compounds are well known rich sources antiviral due their structural diversity safety. In study, we screened thirteen phenolic acids (Cinnamic acid Hydroxy benzoic derivatives) compare...
Background: Human Papillomavirus (HPV) is the main biological agent causing Sexually Transmitted Diseases (STDs), including precancerous lesions and several types of prevalent cancers. To date, numerous vaccines are designed to prevent high-risk HPV. However, their prophylactic effect not same does clear previous infections. Therefore, there an urgent need for developing therapeutic that trigger cell-mediated immune responses treatment The HPV16 E6 E7 proteins ideal targets vaccine therapy...
Abstract Background Airway remodeling, a hallmark of chronic obstructive pulmonary disease (COPD) and Mustard lung disease, is influenced by the Trefoil Factor 3 (TFF3). This study sought to pinpoint compound with minimal toxicity that can effectively suppress TFF3 expression activity. Methods Results We employed an integrative approach, combining gene analysis, molecular docking, dynamics simulations, identify potential inhibitors. The biological safety these compounds was ascertained using...
Background: Virtual screening (VS) is essential for analyzing potential drug candidates in discovery. Often, this involves the conversion of large volumes compound data into specific formats suitable computational analysis. Managing and processing wealth information, especially when dealing with vast numbers compounds various forms, such as names, identifiers, or SMILES strings, can present significant logistical technical challenges. Methods: To streamline process, we developed PyComp, a...
Abstract GM1 gangliosidosis is one type of hereditary error metabolism that occurs due to the absence or reduction β‐galactosidase enzyme content in lysosome cells, including neurons. In vitro, use neural cell lines could facilitate study this disease. By creating a model on SH‐SY5Y human nerve line, it possible understand main role breaking down lipid substrate and other pathophysiologic phenomena To knock‐out GLB1 gene, guides targeting exons 14 16 gene were designed using CRISPOR...
Multipotent mesenchymal stromal/stem cells (MSCs) refer to a population of stem that exhibit distinct progenitor cell characteristics including the potential for differentiation into wide range types. MSCs have become promising candidate therapy and tissue regeneration due their unique properties, such as ability differentiate multiple types, capacity expansion, self-renewal, immune-regulatory effects. However, reports brought attention thrombosis-related complications associated with in...
Background: Glioblastoma is a type of brain tumor with poor response to available therapies, and shows high rate mortality. Despite remarkable advancements in our knowledge about cytogenetic pathophysiologic features glioblastoma, current treatment strategies are mainly based on cytotoxic drugs; however, these therapeutic approaches facing progressive failure because the resistant nature glioblastomas. In recent years, promising results have emerged owing targeted therapies toward molecular...
Adrenomedullin (AM) has high expression in the spinal cord. In this study, we investigated of AM and its receptor components, including calcitonin receptor-like (CLR) activity modifying proteins (RAMPs) dorsal root ganglion (DRG) motor (SM) neurons. Furthermore, effects on cAMP/cAMP response element-binding protein (CREB), AKT/glycogen synthase kinase-3 beta (GSK-3β) signaling pathways, expressions brain-derived neurotrophic factor (BDNF) neurotrophin-3 (NT-3) were evaluated.Rat embryonic...