A5027577680- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Cancer Research and Treatments
- HER2/EGFR in Cancer Research
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Phagocytosis and Immune Regulation
- CAR-T cell therapy research
- Noise Effects and Management
- Wnt/β-catenin signaling in development and cancer
- Autophagy in Disease and Therapy
- Melanoma and MAPK Pathways
- Virus-based gene therapy research
- Plant chemical constituents analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Monoclonal and Polyclonal Antibodies Research
- Tryptophan and brain disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- Dermatology and Skin Diseases
- Electrospun Nanofibers in Biomedical Applications
- Cancer Genomics and Diagnostics
Tehran University of Medical Sciences
2015-2025
Motamed Cancer Institute
2014-2024
Imam Khomeini Hospital
2020
University of Tehran
2014-2015
Islamic Azad University, Tehran
2012
Cancer Research Center
2011
<title>Abstract</title> Background Advancements in the management of gastric cancer (GC) and innovative therapeutic approaches highlight significance role biomarkers GC prognosis. Machine-learning (ML)-based methods can be applied to identify most important predictors unravel their interactions classify patients, which might guide prioritized treatment decisions. Methods A total 140 patients with histopathological confirmed who underwent surgery between 2011 2016 were enrolled study. The...
Umbelliprenin (UMB) has shown various pharmacological properties in vitro. We investigated the antineoplastic and immunostimulatory effects of UMB 4T1 mammary‐tumor‐bearing mice. Two‐hundred microliter (12.5 mg/ml) was intraperitoneally administrated to healthy tumor‐bearing female Balb/c mice for a period 18 days. Data analyzed using GraphPad Prism 5 software Windows (version 5, La Jolla, CA). caused significant decrease tumor size ( P < 0.01). Serum interferon gamma (IFNγ) augmented...
Colorectal cancer is the most common malignancy of gastrointestinal tract with very high mortality. One distinguishing features for establishment an epithelial-mesenchymal transition phenotype alteration mesenchymal markers and structural adhesion proteins. We investigated level Vimentin E-cadherin expression in relation to invasion metastasis on colorectal patients. Tissue specimens were collected consecutively from thirty-nine carcinoma patients during surgeries. The diagnosed treated...
Large-scale production and noninvasive methods for harvesting mesenchymal stem cells (MSCs), particularly in elderly individuals, has prompted researchers to find new patient-specific sources MSCs regenerative medicine. This study aims produce from human induced pluripotent (hiPSCs) evaluate their therapeutic effects a CCl4-induced mouse model of fulminant hepatic failure (FHF). hiPSC-MSCs have shown MSC morphology, antigen profile differentiation capabilities, improved function our model....
Purpose: Triple-negative breast cancer (TNBC) is specified by high vascularity and repetitious metastasis. Although several studies have indicated that angiogenesis has an important role in invasive cancer, a suitable model of TNBC can show the exact onset factors still needs to be developed. The purpose this study determine expression level different clinical stages 4T1 tumor as mouse model. Methods: Twenty mice were injected cell line, four selected healthy controls. Following induction,...
Canine mammary gland tumors (CMGTs) are the most common tumor found in bitches. Changes HER-2/neu genes human breast cancer (HBC) lead to decrease disease-free survival (DFS) and overall rate (OSR). Previous studies have demonstrated that biological behavior of malignant (MMGTs) is similar HBC. The present study aimed at evaluating relationship between overexpression clinicopathological features MMGTs represent a model prognostic factors for HBC.The data 35 were obtained. Immunohistochemical...
Human cytomegalovirus (HCMV), as a ubiquitous and opportunistic virus, is matter for consideration in broad-spectrum diseases, specifically immunocompromised individuals. In recent decades, many studies that have evaluated the role of HCMV inflammation malignancies, especially high-grade gliomas, reported inconsistent results. Thus, this study was conducted to analyze 97 primary gliomas human CMV UL83 gene protein through TaqMan real-time polymerase chain reaction immunohistochemistry,...
Abstract Development of engineered non-pathogenic bacteria, capable expressing anti-cancer proteins under tumor-specific conditions, is an ideal approach for selectively eradicating proliferating cancer cells. Herein, using hypoxia responding nirB promoter, we developed Escherichia coli BW25133 strain cardiac peptides and GFP signaling protein hypoxic condition spatiotemporal targeting mice mammary tumors. Following determination the in vitro cytotoxicity profile selective accumulation...
Background: Tumor angiogenesis correlates with recurrence and appears to be a prognostic factor for both breast prostate cancers. In the present study, we aimed investigate correlation of microvessel density (MVD), measure angiogenesis, nuclear pleomorphism, mitotic count, vascular invasion in cancers at preclinical clinical levels. Methods: Samples from xenograft tumors luminal B cancer adenocarcinoma, established by BT-474 PC-3 cell lines, respectively, commensurate human paraffin-embedded...
Human epidermal growth factor receptor (HER) status is an important prognostic in breast cancer. There no globally accepted method for determining its status, and which most precise still a matter of debate. We here analyzed HER2 mRNA expression by quantitative reverse transcription-PCR (qRT-PCR) DNA amplification using multiplex ligation-dependent probe (MLPA). In parallel, we performed routine evaluation protein immunohistochemistry (IHC). To assess the accuracy RT-PCR MLPA techniques,...
Breast cancer is the most common malignancy among women in both developed and developing countries. The burden increasing low-income middle-income countries (LMCs) threatens public health of such societies. Introduction expensive monoclonal antibodies to treatment regimens poses a real challenge systems LMCs. Despite controversy cost-effectiveness bevacizumab breast cancer, some studies indicate gain patients from this drug. present study aimed propose priority setting model for...
Canine malignant mammary gland tumors (CMMGTs) are the most common malignancies observed in females. Several biological similarities have been reported between CMMGTs and human breast cancer (HBC). The present study aimed to assess correlation of vimentin filaments overexpression, as part process epithelial-mesenchymal transition (EMT) clinicopathological characteristics CMMGTs. 42 were collected. Paraffin-embedded blocks underwent immunohistochemistry staining, which was performed using (to...
Abstract To examine the effect of topical phosphatidylserine (PS) on wound healing factors and tissue necrosis in vivo models. Topical PS was applied to evaluate aspects process growth production vascular endothelial (VEGF) as well a reduction skin flap rat Moreover, phenytoin (PHT) cyclosporine A (CsA) were used topically positive control treatments models, respectively. Immunohistochemistry (IHC) VEGF, transforming factor‐β (TGF‐β), fibroblast factor (FGF) histopathology analysed wounds...
Background: Cutaneous melanoma, the most severe form of skin cancer, has an unpredictable behavior and a high mortality rate. Recent research identified new biomarkers their associations with certain histopathological features, offering essential insights into diagnosis, prognosis, therapeutic strategies. Material method: In this meticulously designed executed study, we analyzed 85 formalin-fixed, paraffin-embedded (FFPE) tissue samples using gold standard technique immunohistochemistry...
Objective(s): The objective of the present study is to explore whether Nanocurcumin improves pancreatic inflammation through inhibition TLR4/NFkB signaling pathway in cerulein-induced acute pancreatitis. Methods: Acute pancreatitis was induced by five intraperitoneal (i.p.) injection cerulein (50 μg/kg) with 1h intervals. Vehicle and nanocurcumin (100mg/kg/day) were given animals oral gavage six days before induction last dose administered 1 hour induction. serum level amylase lipase tissue...