Persistent infection caused by biofilm is an urgent in medicine that should be tackled new alternative strategies. Low efficiency of classical treatments and antibiotic resistance are the main concerns persistent due to formation which increases risk morbidity mortality. The gene expression patterns cells differed from those planktonic cells. One promising approaches against biofilms nanoparticle (NP)-based therapy NPs with multiple mechanisms hinder bacterial or forms. For instance, such as...

Biofilm formation is an important causative factor in the expansion of carious lesions enamel. Hence, new approaches to efficient antibacterial agents are highly demanded. This study was conducted evaluate antimicrobial-biofilm activity chitosan hydrogel (CS gel), zinc oxide/ zeolite nanocomposite (ZnONC) either separately or combined together [ZnONC / CS gel (ZnONC-CS)] against Streptococcus mutans biofilm. MTT assay demonstrated that ZnONC-CS exhibits a non-cytotoxic effect (> 90% cell...

Aim: This study was conducted to determine the potentials of egg lecithin (egg-l) and soy (soy-l) liposomes in antioxidative wound healing properties. Materials & methods: The suspensions egg-l soy-l were prepared using fusion technique. free radical scavenging activity both evaluated by DPPH ABTS methods. Tissue staining used assess wound-healing parameter. Results: Liposomal lecithins showed an increasing trend 1-10 mg/ml radical-scavenging activities (p < 0.0001). Wound-healing...

<b>Background:</b> Curcumin is well known in biomedical investigations with an extensive antimicrobial properties and wound repair effect. However, clinical criteria recommend curcumin should be formulated for topical medication. <b>Material method:</b> In this study, we prepared Ethosomal (Etho-cur) formulation healing bacterial flora assessments treated rats which were subjected to second degree burn under a standard procedure. <b>Results:</b> Applying once daily of Etho-cur (0.2%)...

Aim: To evaluate the antimicrobial effects of photoexcited silver sulfadiazine nanoliposomes (AgSD-NLs) doped by curcumin (AgSD-NLs@Cur) on Acinetobacter baumannii. Materials & methods: Following characterization, cytotoxic and hemolytic activities AgSD-NLs@Cur were evaluated. The AgSD-NLs@Cur-mediated photodynamic therapy (aPDT) determined. Histopathological examination burn wound sites infected mice treated with was assessed. Results: No significant observed. There a decrease in baumannii...

Nanoethosomal formulation containing silver sulfadiazine (SSD) was used to reduce bacterial burden and healing time in burn injuries.Ethosomal formulations were characterized for their size, ζ-potential, morphology, drug encapsulation efficiency vitro release kinetics of SSD.The optimized nanoethosomal suspension with a size 206.7 ± 1.18, ζ-potential value -67.3 0.45 mV exhibited high SSD (92.03 0.79%). Results antimicrobial tests indicated SSD-loaded ethosome led significant reduction...

Aluminum phosphide (AlP) is used as pesticide in some countries for protection of stored grains. Human poisoning with AlP due to suicide attempt or accidental environmental exposure associated very high mortality partially development severe metabolic acidosis. Previous studies have shown that hemoglobin has buffering capacity and erythrocytes can potentially be management The aim this study was evaluate the effect fresh packed red blood cells (RBC) transfusion on survival cardiovascular...

Aim: To evaluate the antibiofilm effect and esp gene downregulation of Enterococcus faecalis through nanozinc oxide fabricated on natural zeolite (NanoZnO/Ze). Materials & methods:Zeolite NanoZnO/Ze materials were characterized by x-ray diffraction, fluorescence field emission scanning electron microscopy coupled with energy dispersive x-ray. Atomic absorption spectroscopy was used to zinc release. E. biofilm formation its expression assessed under nanocomposite treatment. Results:...

Nanoemulsion has shown many advantages in drug delivery systems. In this study, for the first time, analgesic and anti-inflammatory properties of a nanomelusion almond oil with without ibuprofen was compared corresponding microemulsion commercial topical gel using formalin carrageenan tests, respectively.Almond (oil phase) mixed Tween 80 Span (surfactants), ethanol (co-surfactant) them distilled water (aqueous then added to mixture at once. Prepared nanoemulsions were pre-emulsified into 100...

Abstract It has been proposed carbon tetrachloride (CCl 4 ) intoxication due to the production of free radicals and serum levels aspartate aminotransferase (AST), alanine (ALT), alkaline phosphatase (ALP) overload results hepatotoxicity. Phosphatidylserine (PS) shown antioxidant activity in numerous studies. Therefore, this study was aimed investigate effects PS liposomes treatment against CCl ‐induced hepatotoxicity a rat model. Male Wistar rats were treated with (10 mg/kg, oral) or...

The goal of the current study was to evaluate anti-inflammatory effect Arthrocen against acetic acid-induced colitis in rats. Acute inflammation produced through intrarectal administration 2 ml diluted acid (4%) solution. All interventions were carried out for 5 days after induction. administered orally at doses 30, 60, and 120 mg kg-1 day-1 . Then, macroscopic microscopic studies performed. Myeloperoxidase (MPO) activity tumor necrosis factor-α (TNF-α) measured by biochemical ELISA methods,...

The present study aimed to evaluate the effect of liposomal arthrocen 2% (ROCEN) on healing burn wound and pain alleviation thermal stimuli in a rat model second-degree burn. results showed that ROCEN formulation significantly improved main parameters short period time (7 days). percentage surface was also reduced compared with control group following once daily application for 14 days. level TGF (transforming growth factor)-β1 cytokine elevated tissue treated almost same as zinc oxide...

To evaluate the safety and efficacy of a new topical skin ointment with natural ingredients (aloe vera, honey, peppermint) for dressing graft donor sites.A double-blind, placebo-controlled, randomized clinical trial.Researchers enrolled patients who were referred split-thickness after burns or surgical wounds on scalp face area. For each patient, thin layer (depth, 0.04 mm; approximate size, less than 15 × 7 cm) was harvested from thigh by plastic surgeon an electric manual dermatome. The...

Abstract Topical ROCEN (Roc), liposomal arthrocen hydrogel, is a robust anti-inflammatory formulation which has been developed for skin diseases such as eczema. Therefore, we aimed to evaluate the efficacy of Roc 2% on healing imiquimod (Imiq)-induced psoriasis in mouse model. Psoriasis was induced by applying Imiq topically mice's back once daily five consecutive days. Moreover, group animal experiments treated with Cyclosporine A (CsA), standard drug, comparison group. The lesions...