A5082781916- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Nitric Oxide and Endothelin Effects
- Pharmacological Effects and Toxicity Studies
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease and Transplantation
- Migraine and Headache Studies
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Receptor Mechanisms and Signaling
- Poisoning and overdose treatments
- Pharmacological Receptor Mechanisms and Effects
- Cardiac Ischemia and Reperfusion
- Monoclonal and Polyclonal Antibodies Research
- Ion Channels and Receptors
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Edible Oils Quality and Analysis
- Gastrointestinal motility and disorders
- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Mast cells and histamine
Tehran University of Medical Sciences
2015-2024
Islamic Azad University, Karaj
2024
University of Southampton
2023
Baxter (Austria)
2022
Islamic Azad University Pharmaceutical Sciences Branch
2020
John Wiley & Sons (United States)
2019
University of Tehran
2016
Abstract It is estimated that 15 percent of individuals with diabetes mellitus suffer from diabetic ulcers worldwide. The aim this study to present a non-thermal atmospheric plasma treatment as novel therapy for wounds. consists ionized helium gas produced by high-voltage (8 kV) and high-frequency (6 kHz) power supply. Diabetes was induced in rats via an intravascular injection streptozotocin. then introduced artificial xerograph wounds the 10 minutes. Immunohistochemistry assays performed...
Cyclosporine A (CsA) is known as a neuroprotective agent against cerebral ischemia/reperfusion (I/R) in animal models. However, the significant therapeutic effects of CsA have been observed high systemic doses or manipulating blood-brain barrier, resulting side and toxicity. As liposome nanocarriers developed for efficient delivery peptide proteins, liposomal (Lipo-CsA) could improve injuries. In this study, formulation (CsA at dose 2.5 mg/kg) was prepared to assess brain injury outcomes 90...
The aim of the present study is to investigate possible protective effect dry olive leaf extract (OLE) against acetic acid-induced ulcerative colitis in rats, as well probable modulatory nitrergic and opioidergic systems on this impact. Olive was administered (250, 500 750 mg/kg) orally for two successive days, starting from induction. To assess involvement OLE, L-NG-Nitroarginine Methyl Ester (10 naltrexone (5 intraperitoneal (i.p.) were applied 30 min before administration respectively....
Abstract Status epilepticus (SE) is a life‐threatening neurologic disorder that can be as both cause and consequence of neuroinflammation. In addition to previous reports on anti‐inflammatory property the anti‐migraine medication sumatriptan, we have recently shown its anticonvulsive effects pentylenetetrazole‐induced seizure in mice. present study, investigated further (i) sumatriptan lithium–pilocarpine SE model rats, (ii) possible involvement nitric oxide (NO), 5‐hydroxytryptamin 1B/1D...
The leading cause of memory impairment is dementia-related disorders. Since current treatments for target the neuroinflammatory pathways, we selected dapsone, an anti-inflammatory agent, to evaluate its effects on scopolamine-induced in mice and underlying role nitric oxide (NO).Scopolamine (1 mg/kg, intraperitoneal [i.p.]) was used induction impairment. animals received various doses dapsone (0.1, 0.3, 1, 5, 10 i.p.). Duration number arms visits Y-maze step-through latency passive-avoidance...
Recent studies suggest an augmentation of endogenous opioids following bile duct ligation (BDL) and their pivotal role in the pathophysiology cholestasis. In this study, effect naltrexone, opioid receptor antagonist, was determined on cholestasis-induced memory impairment possible involvement nitric oxide (NO) effect. Male Albino-Wistar rats were randomized to sham-operated BDL-operated groups. each group, animals treated for up 28 days with saline; naltrexone (10 mg/kg);...
Aluminum phosphide (AlP) is used as pesticide in some countries for protection of stored grains. Human poisoning with AlP due to suicide attempt or accidental environmental exposure associated very high mortality partially development severe metabolic acidosis. Previous studies have shown that hemoglobin has buffering capacity and erythrocytes can potentially be management The aim this study was evaluate the effect fresh packed red blood cells (RBC) transfusion on survival cardiovascular...
This study was planned to evaluate the effects of sumatriptan, 5-HT1B/1D receptors agonist, on ischaemia/reperfusion injury in bilateral testes after unilateral testicular torsion/detorsion rats. Male Wistar rats (n = 42) were allocated into a sham-operated group, control group and treatment groups which injected sumatriptan (0.1, 0.3 1 mg/kg), GR-127935 (0.01 mg/kg)—5-HT1B/1D antagonist—and (0.1 mg/kg) + mg/kg). Torsion induced for hr by rotating right testis 7200 clockwise direction, 7...