A5011470769- Gut microbiota and health
- Thyroid Disorders and Treatments
- Digestive system and related health
- Clostridium difficile and Clostridium perfringens research
- Growth Hormone and Insulin-like Growth Factors
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- Ophthalmology and Eye Disorders
- Diet, Metabolism, and Disease
- Helicobacter pylori-related gastroenterology studies
- Diabetes and associated disorders
- Neuroendocrine Tumor Research Advances
- Bone health and osteoporosis research
- Parasitic Infections and Diagnostics
- Genetic factors in colorectal cancer
- Eosinophilic Esophagitis
- Vitamin D Research Studies
Amsterdam University Medical Centers
2020-2023
University of Amsterdam
2020-2023
Background The increasing interest to perform and investigate the efficacy of fecal microbiota transplantation (FMT) has generated an urge for feasible donor screening. We report our experience with stool recruitment, screening, follow-up, associated costs in context clinical FMT trials. Methods Potential donors, aged between 18−65 years, underwent a stepwise screening process starting extensive questionnaire followed by feces blood investigations. When eligible, donors were rescreened MDROs...
Hashimoto's thyroiditis (HT) is a common endocrine autoimmune disease affecting roughly 5% of the general population and involves life-long treatment with levothyroxine, as no curative yet exists. Over past decade, crosstalk between gut microbiota host immune system has been well-recognised, identifying microbiome an important factor in health disease, including susceptibility to diseases. Previous observational studies yielded link disruption composition HT. This first study that...
Background: Previous studies have reported gut microbiome alterations in Hashimoto's autoimmune thyroiditis (HT) patients. Yet, it is unknown whether an aberrant present before clinical disease onset participants susceptible to HT or reflects the effects of itself. In this study, we report for first time a comprehensive characterization taxonomic and functional profiles microbiota euthyroid seropositive seronegative participants. Our primary goal was determine signatures intestinal...
Background Graves’ disease (GD) and orbitopathy (GO) result from ongoing stimulation of the TSH receptor due to autoantibodies acting as persistent agonists. Orbital pre-adipocytes fibroblasts also express receptor, resulting in expanded retro-orbital tissue causing exophthalmos limited eye movement. Recent studies have shown that GD/GO patients a disturbed gut microbiome composition, which has been associated with increased intestinal permeability. This study hypothesizes enhanced...
Whether an association between oral levothyroxine use, leading to supraphysiological exposure of the colon thyroid hormones, and risk colorectal cancer exists in humans is unclear. We therefore aimed assess whether use associated with a reduced linked cohort pharmacy data.
Previous studies have reported that the gut microbiome is altered in patients with Hashimoto’s autoimmune thyroiditis. However, it yet unknown whether this dysbiosis present prior to clinical disease onset participants susceptible thyroiditis or merely reflects effects of itself. This first study examine taxonomic and functional profile intestinal microbiota euthyroid positive serum levels (N=159) anti-TPO antibodies (TPOAb) relation seronegative healthy controls (N=1,309), from three ethnic...