A5101711200- Cellular Mechanics and Interactions
- Congenital heart defects research
- Genetic and Kidney Cyst Diseases
- Pluripotent Stem Cells Research
- Developmental Biology and Gene Regulation
- Microtubule and mitosis dynamics
- Hippo pathway signaling and YAP/TAZ
- Cardiac Imaging and Diagnostics
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Sustainability in Higher Education
- Renal and related cancers
- Morphological variations and asymmetry
- Intestinal Malrotation and Obstruction Disorders
- Mitochondrial Function and Pathology
- Environmental, Ecological, and Cultural Studies
- Zebrafish Biomedical Research Applications
- Scoliosis diagnosis and treatment
- Biocrusts and Microbial Ecology
- Connective tissue disorders research
- Interdisciplinary Research and Collaboration
- Atrial Fibrillation Management and Outcomes
- Nanopore and Nanochannel Transport Studies
Lomonosov Moscow State University
2001-2025
Russian Academy of Sciences
2024-2025
Moscow State University
2022-2024
Biotechnology Research Center
2024
Koltzov Institute of Developmental Biology
2021-2023
Engelhardt Institute of Molecular Biology
2023
Scientific Center of Children's Health
2021
Ministry of Health of the Russian Federation
2021
Institute of Experimental Medicine
2017-2018
Institute of Cytology
2015-2018
Abstract Background The planar cell polarity (PCP) signalling pathway is fundamental to a number of key developmental events, including initiation neural tube closure. Disruption the PCP causes severe defect craniorachischisis, in which almost entire brain and spinal cord fails close. Identification mouse mutants with craniorachischisis has proven powerful way identifying molecules that are components or regulators pathway. In addition, identification an allelic series mutants, hypomorphs...
Initially identified in DNA damage repair, ATM-interactor (ATMIN) further functions as a transcriptional regulator of lung morphogenesis. Here we analyse three mouse mutants, Atmingpg6/gpg6, AtminH210Q/H210Q and Dynll1GT/GT, revealing how ATMIN its target dynein light chain LC8-type 1 (DYNLL1) are required for normal morphogenesis ciliogenesis. Expression screening ciliogenic genes confirmed Dynll1 to be controlled by revealed moderately altered expression known intraflagellar transport...
Gastrulation in amphibian embryos is a composition of several differently located morphogenetic movements which are perfectly coordinated with each other both space and time. We hypothesize that this coordination mediated by biomechanical interactions between different parts gastrulating embryo based upon the tendency part to hyper-restore value its mechanical stress (see Beloussov Grabovsky, doi: 10.1387/ijdb.052056). The entire process gastrulation considered as chain these mutually...
Abstract Vertebrate organs show consistent left–right (L‐R) asymmetry in placement and patterning. To identify genes involved this process we performed an ENU‐based genetic screen. Of 135 lines analyzed 11 showed clear single gene defects affecting L‐R patterning, including 3 new alleles of known mutants novel loci. We identified six (termed “gasping”) that, addition to abnormal patterning associated cardiovascular defects, had complex phenotypes pulmonary agenesis, exencephaly, polydactyly,...
Multiple signalling pathways maintain human embryonic stem cells (hESC) in an undifferentiated state. Here we sought to define the significance of G protein signal transduction preservation this state distinct from other cellular processes. Continuous treatment with drugs targeting G(αs)-, G(α-i/o)- and G(α-q/11)-subunit mediators were assessed independent hESC lines after 7days discern effects on normalised alkaline phosphatase positive colony frequency vs total cell content. This...
Trimetazidine (TMZ) was shown to reduce angina symptoms and increase the exercise capacity in stable (SA) patients. A new formulation allowing a once-daily (od) dosage could improve patients' satisfaction adherence. ODA 3-month, observational, multicenter, prospective Russian study SA patients with persistent despite therapy. Angina attack frequency, short-acting nitrate (SAN) consumption, adherence antianginal medications, overall efficacy tolerability of TMZ 80 mg od were assessed...
Abstract Background Vertebrates show clear asymmetry in left-right (L-R) patterning of their organs and associated vasculature. During mammalian development a cilia driven leftwards flow liquid leads to the left-sided expression Nodal , which turn activates asymmetric transcription factor Pitx2 . While drives many aspects morphogenesis, it is from published data that additional asymmetrically expressed loci must exist. Results A L-R screen identified cytoskeletally-associated gene, actin...
Trimetazidine (TMZ) has been shown to be efficacious for angina treatment. The TMZ 80-mg formulation allows one-daily (od) dosage, which could improve symptom control and adherence. 3-month, observational, multicenter, prospective ODA (antianginal effectiveness tolerability of trimetazidine modified release 80 mg Once Daily in stable Angina patients real-world practice) study assessed od with persistent symptoms despite therapy. Two clinical situations were compared: who initiated treatment...
Education is an important mechanism of sustainable development implementation. for (ESD) one the priorities international organizations (UN, UNESCO, and other), national governments from beginning 1990s. Experience generated over three decades implementation ESD, as well theoretical studies show that a whole-institution approach required effective furthering ESD. Withing this shift including ESD issues into few selected subjects or events to applying foundation entire functioning educational...
N6-methyladenosine (m6A) is one of the most abundant modifications both eukaryotic and prokaryotic mRNAs. Recent years witnessed an accumulation a large volume experimental data on involvement m6A methylation in regulation stability translation different Remarkably, up until recently, majority such m6A-related studies have been focused cytoplasmic functions this modification. In review, we overview number novel revealing role several key biological processes occurring cellular nucleus, as...
Abstract Paracrine functions of mesenchymal stem (stromal) cells (MSCs) rely, at least partly, on membrane-bound extracellular vesicles (EVs) with rich composition lipids, nucleic acids and signaling proteins. Elucidation the underlying chemistry could potentially lead to MSCs-free therapy. However, secretome MSCs (EVs’ composition) is non-static depends many other factors including surrounding medium. Thus, research techniques must be able provide not only bulk but microscopy-scale data...
Ecological specialists have an important role to play in achieving the Sustainable Development Goals adopted by United Nations. To do this, they need not only professional, field-specific (hard), skills but also universal, meta-subject soft skills. The article presents results of a survey study attitude students, future ecologists (229 respondents), formation educational process. data obtained are generally consistent with well-known models flexible (in particular, “4Cs”), as well core...