Leila del Castillo Saad

ORCID: 0000-0003-4885-274X
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About
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Research Areas
  • Mosquito-borne diseases and control
  • Zoonotic diseases and public health
  • Viral Infections and Vectors
  • Virology and Viral Diseases
  • Animal Disease Management and Epidemiology
  • Primate Behavior and Ecology
  • Birth, Development, and Health
  • Pregnancy and preeclampsia studies
  • Agricultural and Food Sciences
  • COVID-19 Impact on Reproduction
  • Global Maternal and Child Health
  • Vector-borne infectious diseases
  • COVID-19 epidemiological studies
  • Botany and Plant Ecology Studies
  • Neonatal Respiratory Health Research
  • Rabies epidemiology and control
  • Environmental and biological studies
  • Plant Ecology and Soil Science
  • Cytomegalovirus and herpesvirus research
  • Science and Education Research
  • Leptospirosis research and findings
  • Immune responses and vaccinations
  • Viral Infections and Outbreaks Research

Universidade de São Paulo
2023-2024

Instituto de Saúde
2023

Governo do Estado de São Paulo
2016-2022

Secretaria da Saúde
2016-2022

Faculdade de Ciências Médicas da Santa Casa de São Paulo
2016

Kings Health Partners
2011-2012

King's College London
2011

Abstract Landscape connectivity is important for a wide range of ecological processes, including to disease spread, once it describes the degree which landscapes facilitate or impede vector and hosts dispersion. Understanding extremely identify where pathogens can move, at what speed, allowing organization vaccination campaigns other preventive measures. To better understand effects landscape on yellow fever virus (YFV) dispersion in Brazil, we used network approach modelled movement...

10.1111/1365-2664.14031 article EN Journal of Applied Ecology 2021-09-18

Abstract Yellow Fever (YF) is a severe disease caused by Virus (YFV), endemic in some parts of Africa and America. In Brazil, YFV maintained sylvatic transmission cycle involving non-human primates (NHP) forest canopy-dwelling mosquitoes, mainly Haemagogus -spp Sabethes- spp. Beginning 2016, Brazil faced one the largest outbreaks recent decades, southeastern region. São Paulo city, was detected October 2017 Aloutta monkeys an Atlantic Forest area. From 542 NHP, total 162 NHP were positive...

10.1038/s41598-020-72794-x article EN cc-by Scientific Reports 2020-09-25

to describe yellow fever occurrence in the state of São Paulo, Brazil, period 2000-2010.this was a descriptive study using data regarding human cases, epizootics non-human primates and virus vector isolation Paulo State, between 2000 2010.three sylvatic outbreaks were registered with 32 cases 15 deaths; occurred unvaccinated individuals exposed form transmission; confirmed before began circulating humans region José do Rio Preto isolated twice vectors.three 2010, two them transition area...

10.5123/s1679-49742016000300009 article EN cc-by-nc Epidemiologia e Serviços de Saúde 2016-09-01

Abstract We investigated the sylvatic yellow fever (SYF) diffusion process in São Paulo (SP) between 2016 and 2019. developed an ecological study of SYF through autochthonous human cases epizootics non-human primates (NHPs) that were spatiotemporally evaluated. used kriging to obtain maps with isochrones representative evolution outbreak characterized its pattern. confirmed 648 SP, 230 deaths 843 NHP epizootics. Two waves identified: one from West East (2016 2017), another Campinas region...

10.1038/s41598-021-95539-w article EN cc-by Scientific Reports 2021-08-11

Zoonotic viruses that originate in wildlife harm global human health and economic prosperity 1 . Understanding virus transmission at the human-animal-environment interface is a key component of pandemic risk-reduction 2,3 disease emergence highest biodiverse, tropical forests undergoing intensive land-use change 4,5 Phylodynamic analyses genomes can powerfully test epidemiological hypotheses, but are rarely applied to animals inhabiting these habitats. Brazil’s densely-populated Atlantic...

10.1101/2022.08.25.22278983 preprint EN cc-by medRxiv (Cold Spring Harbor Laboratory) 2022-08-26

to characterize cases of congenital syndrome associated with Zika virus infection (CZS) and other infectious etiologies, resident in the state São Paulo, Brazil, from October 30, 2015, June 2017.this was a descriptive study suspected CZS etiologies notified on Public Health Events Registry.960 were investigated up epidemiological week 26/2017, 146 confirmed for infection; these, 59 (40.4%) without etiological identification 87 (59.6%) laboratory confirmation, which 55 32 agents.this enabled...

10.5123/s1679-49742018000300012 article ES cc-by-nc Epidemiologia e Serviços de Saúde 2018-11-01

Objetivos: Descrever a ocorrência de febre amarela (FA) no estado São Paulo (SP) entre 2016 e 2019 e, após ajuste para cobertura vacinal, avaliar associações com variáveis ambientais demográficas. Métodos: Este estudo ecológico casos autóctones confirmados FA em SP abril maio 2019, considerou modelos gaussianos bayesianos latentes, efeitos aleatórios espaciais nível município distribuições probabilidade binomial negativa Poisson inflado não por zero, onde foram considerados também taxa...

10.14393/hygeia2070448 article PT cc-by-nc-nd Hygeia - Revista Brasileira de Geografia Médica e da Saúde 2024-05-17

RESUMO Objetivo: Apresentar uma análise abrangente da ocorrência febre amarela (FA) no estado de São Paulo desde a sua reemergência e o processo contínuo estruturação vigilância epizootias em primatas não humanos (PNHs) numa abordagem saúde única. Métodos: Estudo descritivo dos casos PNHs, bem como das ações estruturantes única empregadas para 2000 2023. Resultados: De 2023, foram registrados 679 confirmadas 857 PNHs FA. Houve intensificação 2017, quando vírus circulou áreas sem recomendação...

10.1590/1980-549720240064.2 article PT cc-by Revista Brasileira de Epidemiologia 2024-01-01

ABSTRACT Objective: to present a comprehensive analysis of YF occurrence in the state São Paulo since its reemergence, and ongoing process structuring surveillance epizootics non-human primates one health approach. Methods: descriptive study human cases primates, actions approach used for yellow fever from 2000 2023. Results: 2023, 679 857 NHPs confirmed were recorded. There was an intensification epizootic 2017, when virus circulated areas without vaccine recommendations state. Conclusion:...

10.1590/1980-549720240064 article EN cc-by Revista Brasileira de Epidemiologia 2024-01-01

Hypertensive diseases in pregnancy are a significant cause of morbidity and mortality, particularly low resource settings (LRS). Pre-eclampsia eclampsia alone claim up to 50 000 women9s lives globally each year, with an estimated fetal case death 7–25% African countries.1 Accurate regular antenatal blood pressure (BP) monitoring is cost effective means for early identification management hypertensive disease pregnancy. No BP devices suitable use LRS have been assessed accuracy <h3>Aim</h3>...

10.1136/adc.2011.300163.28 article EN Archives of Disease in Childhood Fetal & Neonatal 2011-06-01

Objetivo: Descrever a casuística de fauna selvagem avaliada no ano 2019, em laboratório referência do Estado São Paulo, Brasil, por meio análises histopatológicas e imunohistoquímicas após implantação um programa piloto vigilância laboratorial. Métodos: estudo descritivo, com levantamento amostras primatas não-humanos, aves outrosmamíferos, recebidas dois centros triagem município Paulo. Para tal, foram revisadas as fichas encaminhamento, relatórios histopatológicos imuno-histoquímicos...

10.57148/bepa.2021.v.18.34707 article PT cc-by-nc BEPA Boletim Epidemiológico Paulista 2021-01-31

<h3>Introduction</h3> 10–15% of maternal mortality global is thought to be attributable pre-eclampsia, claiming up 40,000 women9s lives each year. In many developing world settings countries, pre-eclampsia frequently under-detected not only because antenatal attendance low, but also inadequate training in accurate blood pressure(BP) measurements and poor equipment quality.123 <h3>Objective</h3> To determine the prevalence hypertension pregnancy unmet need for pressure measurement amongst...

10.1136/fetalneonatal-2012-301809.121 article EN Archives of Disease in Childhood Fetal & Neonatal 2012-04-01

The state of São Paulo has been monitoring cases microcephaly and pregnant women presenting with acute rash, through CeVeSP.This was a descriptive study focusing on rash the outcome their pregnancy, based notifications CeVeSP.During 2016, 2,209 were reported investigated. Of these, 36.6% confirmed. who tested positive for ZIKV, 6.4% did not have favorable outcome.Our results allowed characterization exposed to ZIKV pregnancy.

10.1590/0037-8682-0351-2018 article EN cc-by Revista da Sociedade Brasileira de Medicina Tropical 2019-01-01

O Centro de Patologia do Instituto Adolfo Lutz (CPA-IAL) é credenciado pelo Ministério da Saúde como laboratório referência macrorregional para a vigilância epidemiológica febre amarela (FA) em seres humanos e primatas não (PNH) Brasil, atuando por meio análise histopatológica imuno-histoquímica (IHQ). Até o ano 2018, ambos os exames eram aplicados todas as amostras PNH recebidas pesquisa FA. Em 2019, implantou-se um algoritmo diagnóstico baseado na triagem pelas características...

10.57148/bepa.2022.v.19.37902 article PT cc-by-nc BEPA Boletim Epidemiológico Paulista 2022-07-19
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