A5062445796- Aldose Reductase and Taurine
- Heart Failure Treatment and Management
- Dialysis and Renal Disease Management
- Potassium and Related Disorders
- Acute Kidney Injury Research
- Cancer, Hypoxia, and Metabolism
- Mycobacterium research and diagnosis
- Cardiac Fibrosis and Remodeling
- Peroxisome Proliferator-Activated Receptors
- Hepatitis C virus research
- Drug Transport and Resistance Mechanisms
- Renal and Vascular Pathologies
- Neonatal Health and Biochemistry
- Electrolyte and hormonal disorders
- Central Venous Catheters and Hemodialysis
- Infectious Diseases and Tuberculosis
- Hepatitis B Virus Studies
- Kidney Stones and Urolithiasis Treatments
- Cardiac Structural Anomalies and Repair
- Cannabis and Cannabinoid Research
- Muscle and Compartmental Disorders
- Lipid metabolism and disorders
- Contact Dermatitis and Allergies
- Myofascial pain diagnosis and treatment
- Computational Drug Discovery Methods
Tel Aviv University
2001-2022
Sheba Medical Center
2011-2022
Hypertension Institute
2013
National Heart Lung and Blood Institute
2006-2011
National Institutes of Health
2008-2009
Rabin Medical Center
2001
Technion – Israel Institute of Technology
1997
Harbor–UCLA Medical Center
1990
University of California, Los Angeles
1990
UCLA Medical Center
1990
Persistent infection with hepatitis C virus (HCV) may lead to hepatocellular carcinoma (HCC). It has been suggested that HCV‐encoded proteins are directly involved in the tumorigenic process. The HCV nonstructural protein NS3 identified as a virus‐encoded serine protease. To study whether oncogenic activity, nontumorigenic rat fibroblast (RF) cells were stably transfected an expression vector containing cDNA for protease (nucleotides 3356–4080). activity was determined cells. grew rapidly...
Glycerophosphocholine (GPC) is an osmoprotective compatible and counteracting organic osmolyte that accumulates in renal inner medullary cells response to high NaCl urea. We previously found increases GPC [Madin-Darby canine kidney (MDCK)] cells. The derived from phosphatidylcholine, catalyzed by a phospholipase was not identified at time. Neuropathy target esterase (NTE) recently shown be B catalyzes production of phosphatidylcholine. purpose the present study test whether NTE contributes...
When activated by high NaCl, tonicity-responsive enhancer–binding protein/osmotic response element–binding protein (TonEBP/OREBP) increases transcription of osmoprotective genes. High NaCl activates TonEBP/OREBP increasing its phosphorylation, nuclear localization, and transactivating activity. In HEK293 cells, mass spectrometry shows phosphorylation TonEBP/OREBP-S120, -S134, -T135, -S155. those residues are individually mutated to alanine, localization is greater for S155A, less S134A...
Spatial summation of thermal pain crosses dermatomal boundaries. In this study we examined whether a vibrational stimulus applied to adjacent or remote dermatomes affects perception the volar forearm. Contact heat at 20C above threshold was applied, and Visual Analog Scale (VAS) used for assessment. We found significant decrease in mean VAS rating when simultaneous vibratory stimuli were given dermatome that receiving stimulation, same on contralateral side. There no change vibration two...
High NaCl elevates activity of the osmoprotective transcription factor TonEBP/OREBP by increasing its phosphorylation, transactivating activity, and localization to nucleus. We investigated possible role in this activation phospholipase C-γ1 (PLC-γ1), which has a predicted binding site at TonEBP/OREBP-phospho-Y143. find following. ( i ) Activation transcriptional high is reduced PLC-γ1 null cells HEK293 knocked down specific siRNA. ii increases phosphorylation Y143. iii Wild-type...
Organic anion transporters (OATs) are located on either the basolateral or apical membrane of proximal tubule cell and mediate absorption secretion various drugs endogenous metabolites. It has been shown that cellular damage in acute kidney injury (AKI) involves three forms injury: sublethal resulting loss polarity, death through apoptosis necrosis. We hypothesize mistargeting OAT proteins AKI will change profile urine. Thirty patients were included study. was defined by clinical course,...
Peritoneal dialysis (PD) is increasingly used for long-term management of refractory congestive heart failure (CHF). In this study, we investigated the outcome patients with CHF treated PD, aiming to identify potential prognostic factors long term-survival.This was a prospective observational study over period 42 months which included 37 patients.Median survival on PD 14 (1-41 months). Long survivors had serum sodium >132 mEq/l (p < 0.001), albumin >3.2 g/dl 0.001) and hospitalization rate...
Objectives: Nontuberculous mycobacteria (NTM) infections pose a diagnostic challenge in peritoneal dialysis (PD) patients. In this study, we sought to identify findings that are suggestive of NTM infection PD adult Methods: All patients with exit-site (ESI) with/without tunnel and peritonitis identified during the last decade eight medical centers Israel were included. Clinical, microbiological, outcome data collected analyzed. Results: Thirty identified; 16 had ESI (53%) 14 (47%). Median...
Severe congestive heart failure (CHF) patients are prone to hyponatremia. Peritoneal dialysis (PD) is increasingly used for long-term management of refractory CHF patients. The glucose polymer icodextrin was proposed be a good option fluid removal in such A small, although statistically significant reduction serum sodium (∼2 mmol/l) consistently observed multiple trials, considered as not clinically relevant. Here we reported five who demonstrated drop by median 8 meq/l (range 5.4–8.3 meq/l)...
Proinflammatory cytokines play a pathogenic role in congestive heart failure. In this study, the effect of peritoneal dialysis treatment on inflammatory levels refractory failure patients was investigated. During treatment, reached well-tolerated edema-free state and demonstrated significant improvement NYHA functional class. Brain natriuretic peptide decreased significantly after 3 months remained stable at 6 months. C-reactive protein, plasma marker inflammation, following treatment....
Hypertonicity, such as induced by high NaCl, increases the activity of transcription factor TonEBP/OREBP whose target genes increase osmoprotective organic osmolytes and heat shock proteins.We used mass spectrometry to analyze proteins that coimmunoprecipitate with in order identify ones might contribute its NaCl-induced activation.We identified 20 unique peptides from Mediator DNA Damage Checkpoint 1 (MDC1) probability. The identification was confirmed Western analysis. We small interfering...
Summary— Among the causes of constricted ureter is benign or malignant encasement. The diagnosis ureteric encasement frequently overlooked, even by well informed clinicians and radiologists. most common cause retroperitoneal fibrosis frequent are extension from an adjacent primary tumour, true metastases to lymphoma. Lack recognition process may lead mistaken inflammatory stricture infiltrating transitional cell with resultant inappropriate management. A sign which appears be almost specific...
Severe congestive heart failure (CHF) patients are prone to hyponatremia. Peritoneal dialysis (PD) is increasingly used for long-term management of refractory CHF patients. The glucose polymer icodextrin was proposed be a good option fluid removal in such A small, although statistically significant reduction serum sodium (∼2 mmol/l) consistently observed multiple trials, considered as not clinically relevant. Here we reported five who demonstrated drop by median 8 meq/l (range 5.4–8.3 meq/l)...
Formaldehyde-free hair-straightening products are hair-smoothening solutions widely used by professional beauty salons. hair straighteners do not technically contain formaldehyde; however, they other chemicals such as glyoxyloyl carbocysteine which releases formaldehyde upon contact with heat. Moreover, its by-product glyoxylate may convert to oxalate; both compounds have potential nephrotoxic effect. Here, we report a case of 41-year-old woman who presented the emergency room weakness,...
Background Peritoneal dialysis (PD) is increasingly used for the long-term management of hypervolemic refractory congestive heart failure (CHF) patients, in particular when complicated by renal insufficiency. While PD has many advantages over hemodialysis (HD) those there a controversy concerning survival superiority compared with HD this population. The aim study was to define typical patient profile and compare outcomes patients CHF treated or PD. Methods This retrospective cohort enrolled...
Cardiac collagen remodeling is important in the progression of heart failure. Estimation cardiac turnover by serum levels serological markers used for monitoring tissue repair and fibrosis. Peritoneal dialysis (PD) long-term management refractory congestive failure (CHF). In this study, we investigated effect PD treatment on circulating fibrosis patients with CHF fluid overload.Twenty-five treated were prospectively enrolled study. Circulating procollagen type III C-peptide (PIIINP), matrix...
Peritoneal dialysis (PD) is increasingly used for the long-term management of refractory congestive heart failure (CHF). Patients with severe CHF and ascites were treated regular at-home abdominal paracentesis via Tenckhoff catheter. We investigated outcome those patients, aiming to identify potential prognostic factors longer survival.Patients referred by cardiologists PD unit from years 2009 2019 catheter without peritoneal exchanges, enrolled into this prospective observational study.From...
The diagnosis of peritonitis among peritoneal dialysis (PD) patients is based on clinical presentation, effluent white blood cell (WBC) count, and culture. Peritoneal fluid WBC count very important in the initial peritonitis. purpose this work was to determine optimal number WBCs with different presentations at admission define PD-related peritonitis.Medical records chronic PD who underwent work-up for suspected between 2008 2019 were reviewed retrospectively. Results all tests during period...