A5053221139- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Neurological disorders and treatments
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Cannabis and Cannabinoid Research
- Surface Modification and Superhydrophobicity
- Artificial Intelligence in Healthcare and Education
- Lung Cancer Diagnosis and Treatment
- Cardiac tumors and thrombi
- Forensic Toxicology and Drug Analysis
- ECG Monitoring and Analysis
- Fluid Dynamics and Heat Transfer
- Infective Endocarditis Diagnosis and Management
- Neurotransmitter Receptor Influence on Behavior
- Wireless Body Area Networks
- Pericarditis and Cardiac Tamponade
- Hematological disorders and diagnostics
Ascension Providence Hospital
2019-2024
Population Health Research Institute
2024
McMaster University
2024
Faculdade Brasil
2024
Providence Hospital
2010-2022
Wayne State University
1993-2022
Providence Hospital
2009-2022
Providence College
2010-2021
Michigan Medicine
2021
Michigan State University
2017-2019
Successful antitachycardia pacing (ATP) terminates ventricular tachycardia (VT) up to 250 bpm without the need for painful shocks in implantable cardioverter-defibrillator (ICD) patients. Fast VT (FVT) >200 is often treated by shock because of safety concerns, however. This prospective, randomized, multicenter trial compares and utility empirical ATP with FVT a broad ICD population.We randomized 634 patients 2 arms-standardized (n=313) or (n=321)-for initial therapy spontaneous FVT. ICDs...
The presence of a cardiovascular implantable electronic device has long been contraindication for the performance magnetic resonance imaging (MRI). We established prospective registry to determine risks associated with MRI at field strength 1.5 tesla patients who had pacemaker or cardioverter-defibrillator (ICD) that was "non-MRI-conditional" (i.e., not approved by Food and Drug Administration scanning).Patients in were referred clinically indicated nonthoracic tesla. Devices interrogated...
Background Implantable cardioverter-defibrillators (ICDs) can terminate some ventricular tachycardias (VTs) painlessly with antitachycardia pacing (ATP). ATP has not routinely been applied for VT >188 bpm because of concerns about efficacy, risk acceleration, and delay definitive shock therapy. This prospective, multicenter study evaluated the efficacy empirical to fast (FVT; bpm). Methods Results Two hundred twenty coronary artery disease patients received ICDs standard indications....
Understanding the cellular entry pathways of synthetic biomaterials is highly important to improve overall labeling and delivery efficiency. Herein, mechanisms conjugated polymer nanoparticles (CPNs) are presented. CPNs intrinsic fluorescent materials used for various biological applications. While cause no toxicity, decreased CPN uptake observed from cancer cells pretreated with genistein, which an inhibitor caveolae-mediated endocytosis (CvME). CvME further confirmed by high...
To determine whether an increased female gender susceptibility to torsades de pointes (TdP) may exist in a clinical model of bradycardia-induced long QT syndrome, we investigated reported cases TdP associated with acquired complete heart block.Seventy-two the medical literature dating from 1941 through 1993 were identified, all describing or "transient ventricular tachycardia/fibrillation" (to include those prior use terminology) setting block unassociated prolonging drugs. Expected...
Many patients who need cardiac resynchronization therapy (CRT) require chronic anticoagulation. Current guidelines recommend discontinuation of warfarin and the initiation anticoagulant "bridging" during these procedures. We evaluated safety CRT-device (CRT-D) implantation without interruption therapy.A total 123 consecutive requiring CRT-D were enrolled, 49 identified as high risk for thromboembolic events received either intravenous heparin, low molecular weight or therapy. The control...
The incidence of conduction disease requiring permanent pacemaker (PPM) implantation following aortic valve replacement (AVR) ranges from 3% to 6%. Data concerning the potential risks for PPM requirement associated with certain types have been conflicting and controversial. We sought evaluate prevalence, predictors implantation, dependency during follow-up in patients undergoing AVR.A total 214 consecutive AVR were studied retrospectively. A 207 included statistical analysis. Clinical...
Wearable devices may be useful for identification, quantification and characterization, management of atrial fibrillation (AF). To date, consumer wrist-worn AF detection using photoplethysmography-based algorithms perform only periodic checks when the user is stationary are US Food Drug Administration cleared prediagnostic uses without intended use clinical decision-making. There an unmet need medical-grade diagnostic that provide long-term, continuous monitoring.
Left ventricular (LV) remodeling has been attributed to the segmental loss of viable myocardium due myocardial infarction (MI), which results in redistribution cardiac workload, with increased regional wall stress and around infarct zone. Because pacing shown reduce workload regions near site, this trial was designed test whether chronic attenuates LV remodeling.Eighty patients an anterior MI, peak creatine kinase >2000 mU/mL, ejection fraction ≤35%, motion abnormality (WMA) >5 16 segments,...
Background In the current age of ever‐increasing healthcare costs, it is utmost importance to adopt strategies that reduce hospital stay and cost, while still maintaining patient safety. this study we review our approach same‐day discharge following implantable cardioverter defibrillator (ICD) placement for primary prevention sudden cardiac death (SCD). Methods We conducted a retrospective chart 415 consecutive patients who underwent ICD implantation SCD between 2007 2010. Patients were...
Background: Patients with implantable devices are generally not permitted to undergo magnetic resonance imaging (MRI) because of potentially deleterious interactions. Little has been reported regarding the safety and effects MRI scanning patients loop recorders (ILRs). We evaluated ILRs output ILR after undergoing MRI. Methods: Ten underwent 11 events. All had Reveal Plus (Medtronic, Minneapolis, MN) ILRs. Seven cranial, two lumbar‐spine, one shoulder, knee were performed. MRIs performed...
Abstract Introduction Leadless pacemaker (LP) is a novel that has been proven to be effective and safe; however, the majority of LPs in previous reports were Medtronic Micra™ VR LP. We aim evaluate implant efficiency clinical performance Aveir™ LP compared Method performed retrospective analysis two healthcare systems (Sparrow Hospital Ascension Health System, Michigan) patients implanted with between January 1, 2018, April 2022. The parameters collected at implantation, 3 months 6 months....
Introduction: Patients in underdeveloped nations have limited access to life‐saving medical technology including cardiac rhythm management (CRM) devices. We evaluated alternative means provide such this patient population while assessing the safety and efficacy of a practice. Methods: United States with clinical indications for extraction CRM devices were consented. Antemortem cleaned sterilized following protocol established at our institution. Surveillance vitro cultures performed quality...
In patients with cardiac sarcoidosis, the sarcoid granulomas usually involve myocardium or endocardium. The disease typically presents as heart failure ventricular arrhythmias, conduction disturbances, both. Constrictive pericarditis has rarely been described in sarcoidosis: we found only 2 reports of this association. We report case a 57-year-old man who presented clinical and hemodynamic features constrictive pericarditis, unclear cause. He was admitted for treatment recurrent pleural...