A5052805202- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Non-Invasive Vital Sign Monitoring
- ECG Monitoring and Analysis
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Semiconductor Quantum Structures and Devices
- Chromosomal and Genetic Variations
- Coronary Interventions and Diagnostics
- Advanced MRI Techniques and Applications
- Plant Molecular Biology Research
- Blood Pressure and Hypertension Studies
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Advanced MEMS and NEMS Technologies
- Legume Nitrogen Fixing Symbiosis
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Public Administration and Political Analysis
- Medical and Health Sciences Research
- Hemodynamic Monitoring and Therapy
- Entomological Studies and Ecology
- Neurotransmitter Receptor Influence on Behavior
TU Dresden
2015-2024
Edwards Lifesciences (Switzerland)
2024
Abbott (Canada)
2024
Universitätsklinikum Erlangen
2009-2022
Tilburg University
2022
VIB-UGent Center for Plant Systems Biology
2016-2020
Ghent University
2016-2020
München Klinik Bogenhausen
2011-2019
RWTH Aachen University
1994-2018
Leipzig University
2018
Amyloid beta-peptide (Abeta)(1-42) oligomers have recently been discussed as intermediate toxic species in Alzheimer's disease (AD) pathology. Here we describe a new and highly stable Abeta(1-42) oligomer which can easily be prepared vitro is present the brains of patients with AD Abeta(1-42)-overproducing transgenic mice. Physicochemical characterization reveals pure, water-soluble globular 60-kDa named 'Abeta(1-42) globulomer'. Our data indicate that globulomer persistent structural entity...
Catheter-based renal sympathetic denervation (RDN) reduces office blood pressure (BP) in patients with resistant hypertension according to BP. Less is known about the effect of RDN on 24-hour BP measured by ambulatory monitoring and correlates response individuals true or pseudoresistant hypertension.A total 346 uncontrolled hypertensive patients, separated daytime into 303 (office systolic [SBP] 172.2±22 mm Hg; SBP 154±16.2 Hg) 43 161.2±20.3 121.1±19.6 Hg), from 10 centers were studied. At...
Oesophageal injury has been reported with delivery of radio-frequency lesions at the left atrium posterior wall in catheter ablation procedures for atrial fibrillation (AF). In this observational study we prospectively assessed endoscopical oesophageal changes after pulmonary vein antrum isolation (PVAI) patients presenting treatment AF. Twenty eight (18 men; mean age 55 ± 11 years) were ablated using either a cooled-tip or an 8 mm tip catheter. Endoscopy oesophagus was performed 24 h PVAI....
Catheter ablation is used extensively with curative intention in atrial fibrillation. Radiofrequency has long been a standard of care, while cryoballoon technology emerged as feasible approach promising results. Prospective multicenter registry data referring to both technologies AF therapy are lacking.Between January 2007 and August 2011, total 3,775 consecutive patients symptomatic paroxysmal who underwent PV their respective centers were enrolled. The cohort was divided into 2 groups...
The photoexcited luminescence spectrum of Sn-doped GaAs is studied as a function the doping range, temperature, and external stress magnetic fields. Two emissions due to Sn acceptor can clearly be distinguished: (${A}^{0},X$) bound-exciton recombination (${D}^{0},{\mathrm{Sn}}^{0}$) pair recombination. bound exciton exhibits an excited state 1.3 meV above ground state. angular momenta are $j=\frac{1}{2} \mathrm{and} \frac{5}{2}$. Only one found in range ${10}^{14}$-${10}^{17}$...
Cryoballoon (CB) ablation results in >70% freedom from atrial fibrillation at 1 year. Single-center data of the first (CBG1) and second (CBG2) cryoballoon, recently introduced, were analyzed to compare safety efficacy.From March 2011 December 2012, CB with spiral mapping was performed consecutively 484 patients symptomatic fibrillation. CBG1 used 364 (75%) CBG2 120 (25%) patients. Periprocedural analyzed. Acute pulmonary vein (PV) isolation only achieved 99.86% 100% veins CBG2, respectively...
Five synthetic approaches to racemic strychnine (1), with the cobalt-mediated [2 + 2 2] cycloaddition of alkynes indoles as key step, are described. These include generation and attempted cyclization macrocycle 8 synthesis dihydrocarbazoles 15, 22, 26 their elaboration pentacyclic structures via a conjugate addition, dipolar cycloaddition, propellane-to-spirofused skeletal rearrangement, respectively. Finally, successful total 1 is discussed. The development short, highly convergent route...
Introduction: We performed a prospective study to compare efficacy and safety of both open irrigation tip (OIT) technology with intracardiac echo (ICE)‐guided energy delivery in patients presenting for PVAI. Methods Results: Fifty‐three PVAI were randomized ablation using an OIT catheter (Group 1, 26 patients; temperature power set at 50° 50 W, respectively, saline pump flow rate 30 mL/min) or radiofrequency (RF) under ICE guidance 2, 27 was titrated based on microbubbles formation). The...
We propose a novel method for evaluating the similarity between two 1d patterns. Our method, referred to as two-dimensional signal warping (2DSW), extends basic ideas of known techniques such dynamic time and correlation optimized warping. By employing piecewise stretching 2DSW is able take into account inhomogeneous variations shapes. apply ECG recordings extract beat-to-beat variability in QT intervals (QTV) that indicative ventricular repolarization lability typically characterised by low...
The methylation of cytosines shapes the epigenetic landscape plant genomes, coordinates transgenerational inheritance, represses activity transposable elements (TEs), affects gene expression and, hence, can influence phenotype. Sugar beet (Beta vulgaris ssp. vulgaris), an important crop that accounts for 30% worldwide sugar needs, has a relatively small genome size (758 Mbp) consisting approximately 485 Mbp repetitive DNA (64%), in particular satellite DNA, retrotransposons and transposons....
The rowing technique is a key factor in the overall performance. Nowadays athletes' performance so advanced that even small differences can have an impact on sport competitions. To further improve performance, individualized necessary. This be achieved by intelligent measurement technology provides direct feedback. address this issue, we developed novel wireless system (WiRMS) acquires movement and measures muscle activity using electromyography (EMG). Our able to measure several parameters...
Abstract Deep learning-based methods have demonstrated high classification performance in the detection of cardiovascular diseases from electrocardiograms (ECGs). However, their blackbox character and associated lack interpretability limit clinical applicability. To overcome existing limitations, we present a novel deep learning architecture for interpretable ECG analysis (xECGArch). For first time, short- long-term features are analyzed by two independent convolutional neural networks...
Abstract One or two cell biopsies were obtained from 6‐7 days old bovine embryos. The sex of the embryos was determined with different Y‐chromosome‐specific primer pairs by using polymerase chain reaction. These results confirmed karyotyping as well in situ hybridization an independent sequence. reaction found to be a quick and accurate method diagnosis preimplantation
Many patients who need cardiac resynchronization therapy (CRT) require chronic anticoagulation. Current guidelines recommend discontinuation of warfarin and the initiation anticoagulant "bridging" during these procedures. We evaluated safety CRT-device (CRT-D) implantation without interruption therapy.A total 123 consecutive requiring CRT-D were enrolled, 49 identified as high risk for thromboembolic events received either intravenous heparin, low molecular weight or therapy. The control...
In the forebrain, synaptic glycine concentrations are regulated through transporter GlyT1. Because is a coagonist of <i>N</i>-methyl-d-aspartate (NMDA) receptor (NMDAR), which has been implicated in schizophrenia, inhibition GlyT1 thought to provide an option for treatment schizophrenia. support this hypothesis, inhibitors facilitate vivo NMDAR function and demonstrate antipsychotic-like effects animal models. Among specific inhibitors, substituted <i>N</i>-methyl-glycine (sarcosine)...
Aims: Pulmonary vein antrum isolation (PVAI) plays a pivotal role in the comprehensive treatment of atrial fibrillation (AF). The need for effective anticoagulation bridging following PVAI is associated with significant vascular complication rates and increased costs. We investigated safety patients therapeutic international normalized ratios (INR) day procedure. Methods: A case‐control analysis was performed on who underwent INR (>2). Patients normal preprocedure served as controls....
Intracardiac Echocardiography Guided Cryoballoon Ablation. Background: ablation is increasingly used for pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF). This new technique aims to perform PVI safer and faster. However, procedure fluoroscopy times were similar conventional RF approaches. We compared ICE plus versus alone anatomical guidance of PVI. Methods: Forty‐three consecutive paroxysmal AF randomly assigned (n = 22) 21) cryoballoon A “single big balloon” using a...