A5019758629- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Sleep and related disorders
- Pituitary Gland Disorders and Treatments
- Frailty in Older Adults
- Sleep and Wakefulness Research
- Functional Brain Connectivity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Health disparities and outcomes
- Growth Hormone and Insulin-like Growth Factors
- Nutrition and Health in Aging
- Atrial Fibrillation Management and Outcomes
- Advanced Neuroimaging Techniques and Applications
- Geriatric Care and Nursing Homes
- Neurological Disease Mechanisms and Treatments
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Acute Ischemic Stroke Management
- Balance, Gait, and Falls Prevention
- Cerebrovascular and Carotid Artery Diseases
- Food Security and Health in Diverse Populations
- Obstructive Sleep Apnea Research
- Salivary Gland Tumors Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Intergenerational Family Dynamics and Caregiving
Karolinska Institutet
2021-2024
University of Padua
2019-2023
Alzheimer’s Disease Neuroimaging Initiative
2023
Union Bank of Switzerland
2023
Mayo Clinic in Arizona
2016-2020
Mayo Clinic
2018-2019
Mayo Clinic in Florida
2016-2019
Johns Hopkins University
2013-2016
The utility of plasma total tau level as a prognostic marker for cognitive decline and dementia is not well understood.To determine (1) the association between level, decline, risk mild impairment (MCI) dementia; (2) whether this differs by presence elevated brain amyloid β (Aβ); (3) associated with over short interval 15 months.The present analyses included 458 participants who were enrolled in population-based cohort study October 2008 June 2013. All had available levels, Aβ positron...
Tau protein levels in plasma may be a marker of neuronal damage. We examined associations between tau and Alzheimer's disease (AD)-related magnetic resonance imaging (MRI) positron emission tomography (PET) neuroimaging measures among nondemented individuals.
Previous studies reported that slower gait speed might predict cognitive impairment and dementing illnesses, supporting the role of as a possible subclinical marker impairment. However, predictive value other parameters for decline is unclear.To investigate compare association with, prediction of, specific cognition in population-based sample.The analysis included 3,426 cognitively normal participants enrolled Mayo Clinic Study Aging. At baseline every 15 months (mean follow-up = 1.93...
Great efforts have been made to improve stroke prevention in atrial fibrillation (AF) patients. Meanwhile, incidence of AF is increasing, which may affect the share AF-related on all strokes. We aimed examine temporal trends ischemic between 2001 and 2020, if it varied by use novel oral anticoagulant drugs (NOAC), relative risk associated with changed over time. Data from total Swedish population aged ≥70 years during period 2001–2020 were used. Annual rate (IR) was calculated for overall...
Transactive response DNA-binding protein 43 (TDP-43) is associated with Alzheimer disease (AD), progressive hippocampal atrophy, and cognitive decline. The apolipoprotein E (APOE) ε4 allele strongly β-amyloid (Aβ) aggregation risk of AD, but its association TDP-43 unknown.To determine whether the APOE a factor for TDP-43.This cross-sectional, genetic-histologic study analyzed genotype, status (positive vs negative), Aβ tau neurofibrillary tangle stage (B0, Braak 0; B1, stages I-II; B2,...
Background: Adiponectin, a protein involved in inflammatory pathways, may impact the development and progression of Alzheimer's disease (AD). Adiponectin levels have been associated with mild cognitive impairment (MCI) AD; however, its association Alzheimer-associated neuroimaging cogn itive outcomes is unknown. Objective: Determine cross-sectional between plasma adiponectin an older population-based sample. Methods: Multivariable adjusted regression models were used to investigate...
ABSTRACT Background: We determined the association between neighborhood socio-environmental factors and insomnia symptoms in a nationally representative sample of US adults aged >50 years. Methods: Data were analyzed from two waves (2006 2010) Health Retirement Study using 7,231 community-dwelling participants (3,054 men 4,177 women) United States. Primary predictors physical disorder (e.g. vandalism/graffiti, feeling safe alone after dark, cleanliness) social cohesion friendliness...
Abstract Background Chronic inflammation has been linked with geriatric-related conditions, including dementia. Inflammatory cytokine levels, interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF) α, in the blood have associated cognitive impairment decline. However, evidence mixed. Methods We examined cross-sectional longitudinal associations between baseline-measured IL-6, TNFα levels ratio of IL-6/IL-10 test performance mild (MCI) among 1,602 community-dwelling older adults (median...
Objectives To determine the cross‐sectional association between cerebral amyloid‐beta (A β ) deposition and gait. Design Cross‐sectional. Setting Population‐based cohort study in Olmsted County, MN . Participants Cognitively normal individuals (n = 611), aged 50 to 69 years, enrolled Mayo Clinic Study of Aging with concurrent PiB‐ PET imaging gait assessment. a history stroke, alcoholism, Parkinson's disease, subdural hematoma, traumatic brain injury, or pressure hydrocephalus were excluded....
<b><i>Purpose:</i></b> The coronavirus disease 2019 (COVID-19) pandemic has put a substantial burden on the Italian healthcare system, resulting in restructuring of hospitals to care for COVID-19 patients. However, this likely impacted access patients experiencing other conditions. We aimed quantify impact with urgent/emergent urological conditions throughout Italy. <b><i>Materials and Methods:</i></b> A questionnaire was sent 33 units AGILE...
Background The role of cholesterol levels in the development atrial fibrillation (AF) is still controversial. In addition, whether and to what extent apolipoproteins are associated with risk AF rarely studied. this study, we aimed investigate association between blood lipid midlife subsequent new-onset AF. Methods findings This population-based study included 65,136 individuals aged 45 60 years without overt cardiovascular diseases (CVDs) from Swedish Apolipoprotein-Related Mortality Risk...
Objectives To determine the association of napping intention, frequency, and duration with cognition in a nationally‐representative sample US older adults. Methods We performed cross‐sectional analysis community‐dwelling Medicare beneficiaries aged ≥65 years from Rounds 3 or 4 (2013‐2014) National Health Aging Trends Study ( N = 2549). Participants reported past‐month intention (intentional/unintentional), frequency (rarely/never [non‐nappers], some days [infrequent nappers], most days/every...