- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Electron Spin Resonance Studies
- Vagus Nerve Stimulation Research
- Advanced Memory and Neural Computing
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Radiation Dose and Imaging
- Atomic and Subatomic Physics Research
- Characterization and Applications of Magnetic Nanoparticles
- Radiation Therapy and Dosimetry
- Cognitive Functions and Memory
- Heart Rate Variability and Autonomic Control
- Advanced NMR Techniques and Applications
- Teaching and Learning Programming
- Wireless Power Transfer Systems
- Cardiovascular Function and Risk Factors
- Scientific Computing and Data Management
- Non-Destructive Testing Techniques
- Microwave Imaging and Scattering Analysis
- Health, Environment, Cognitive Aging
- Advanced Radiotherapy Techniques
- Magnetic Properties and Applications
United States Food and Drug Administration
2024
Athinoula A. Martinos Center for Biomedical Imaging
2020-2024
Massachusetts General Hospital
2020-2024
Center for Devices and Radiological Health
2023-2024
Office of Science
2024
Harvard University
2020-2024
National Institute of Mental Health
2024
Boston Children's Hospital
2024
St. Michael's Hospital
2024
University of Oxford
2020-2023
We introduce a new electroencephalogram (EEG) net, which will allow clinicians to monitor EEG while tracking head motion. Motion during MRI limits patient scans, especially of children with epilepsy. is also severely affected by motion-induced noise, predominantly ballistocardiogram (BCG) noise due the heartbeat.
Numerical body models of children are used for designing medical devices, including but not limited to optical imaging, ultrasound, CT, EEG/MEG, and MRI. These in many clinical neuroscience research applications, such as radiation safety dosimetric studies source localization. Although several adult have been reported, there few reports full-body pediatric models, those described limitations. Some, example, either morphed from older or do detailed segmentations. Here, we introduce a...
. Combining magnetic resonance imaging (MRI) and electroencephalography (EEG) provides a powerful tool for investigating brain function at varying spatial temporal scales. Simultaneous acquisition of both modalities can provide unique information that single modality alone cannot reveal. However, current simultaneous EEG-fMRI studies are limited to small set MRI sequences due the image quality safety limitations commercially available MR-conditional EEG nets. We tested whether Inknet2,...
Purpose Safety limits for the permitted specific absorption rate (SAR) place restrictions on pulse sequence design, especially at ultrahigh fields (≥ 7 tesla). Due to intersubject variability, SAR is usually conservatively estimated based standard human models that include an applied safety margin ensure safe operation. One approach reducing create more accurate subject‐specific from their segmented MR images. This study uses electromagnetic simulations investigate minimum number of tissue...
Recently, white-matter fiber tract pathways carrying neural signals through the brain were shown to follow curved, orthogonal grids. This study focuses on how these fibers may be selectively excited using micromagnetic stimulation (μMS), a new type of neuronal stimulation, which generates microscopic eddy currents capable directionally activating neurons. One most remarkable properties this novel is that μMS fields provide unique directional activation elements not seen with traditional...
Vagus nerve stimulation (VNS) is commonly used to treat drug-resistant epilepsy and depression. The therapeutic effect of VNS depends on stimulating the afferent vagal fibers. However, vagus a mixed containing efferent fibers, cardiac fibers during may produce rare but severe risk bradyarrhythmia. This side challenging mitigate since VNS, via electrical technology in clinical practice, requires unique electrode design pulse optimization for selective only Here we describe method using...
Purpose To assess the accuracy of morphing an established reference electromagnetic head model to a subject‐specific morphometry for estimation specific absorption rate (SAR) in 7T parallel‐transmit (pTx) MRI. Methods Synthetic T 1 ‐weighted MR images were created from three high‐resolution open‐source voxel models. The “reference” (multimodal image‐based detailed anatomical [MIDA]) into different subject's native space (Duke and Ella) was compared. Both linear nonlinear registration methods...
To enhance RF safety when implantable medical devices are located within the body coil but outside imaging region by using a secondary resonator (SR) to reduce electric fields, corresponding specific absorption rate (SAR), and temperature change during MRI.This study was conducted numerical simulations with an American Society for Testing Materials (ASTM) phantom adult human models of Ella Duke from Virtual Family Models, along experimental results obtained ASTM phantom. The circular SR...
This article investigates the radiofrequency (RF) induced heating in a pediatric whole-body voxel model with high-density electroencephalogram (hd-EEG) net during magnetic resonance imaging (MRI) at 3 T. A total of three cases were studied: no (NoNet), resistive hd-EEG (NeoNet), and copper (CuNet) net. The maximum values specific absorption rate averaged over 10g-mass (10gSAR) head calculated; NeoNet, it was 12.51 W/kg case NoNet 12.40 W/kg. In contrast, CuNet generated 17.04 W/Kg....
Have you ever wondered how doctors and scientists test new medical devices or study the body works? They often use computer models, which are like digital dolls that simulate human body. But did know there only few models of children, especially girls? That is where Athena comes in. a brand-new model healthy 3.5-year-old girl’s body, made using real-life pictures her brain organs. We even had check to make sure was accurate. so detailed she has 267 parts, including 50 components alone....
The influence of the thickness, loss tangent value lead insulation material along with length effects on heating an active implantable medical device (AIMD) electrode is analyzed using full-wave EM simulations. Decreasing thickness decreases significantly when lengths are less than or equal to wavelengths in medium. Increasing has a moderate effect reducing at electrode. Standing wave distortions affect greater
Motivation: The TF validation process is time-consuming work. Here, we reduced the burden of approach using a low power tabletop E-field generator. Goal(s): Using to estimate RF-induced heating stent tip at 3T generator and compared predicted values against estimated values. Approach: was measured via piX method 128MHz . validated by exposing device under diverse test fields table-top body coil used evaluate approach. Results: with low-power Impact: could aid estimating heating, not only...
Motivation: RF-induced heating for the partially-in and partially-out (PIPO) medical implants is primary concern patient’s safety under MRI. Goal(s): Winding external portion of PIPO electrodes proposed to reduce RF 1.5T Approach: One commercial electrode an insulated solid wire were used demonstrate this concept. measured inside ASTM phantom a birdcage coil evaluated from in-vivo simulations using transfer function (TF) approach. Results: The results showed significant reduction...
EEG provides valuable clinical information, but nets produce artifacts in MRI and CT images, preventing these modalities from being combined typical practice. We tested whether a new MR-compatible net, called the R-Net-MR-IT, could high-quality research images. assessed image quality MR images on phantom with conventional no net. then performed same comparison humans, as well fMRI scans. Our results show that R-Net-MR-IT enables acquisition of high minimal artifact hardware.
We propose a workflow for validating parallel transmission (pTx) radio-frequency (RF) magnetic field heating patterns using Proton-Resonance Frequency shift (PRF)-based MR thermometry. Electromagnetic (EM) and thermal simulations of 7 T 8-channel dipole coil were done commercially available software (Sim4Life) to assess RF heating. The fabrication method phantom with electrical properties matched human tissue is also described, along methods its characterisation. Energy was deposited...
This study investigates the effects of EEG traces in B1 transmit field distortion a 3T MRI. is non-invasive method to monitor brain activities. Although monitors activities with high temporal resolution, it has trouble localizing signal source. The EEG-fMRI multimodal imaging method, but care needed use while MRI as create To tackle this problem, resistive are developed using thin-film technology reduce during Numerical simulation was used estimate amount NeoNet and copper-based nets (CuNet...
. Numerical models are central in designing and testing novel medical devices studying how different anatomical changes may affect physiology. Despite the numerous adult available, there only a few whole-body pediatric numerical with significant limitations. In addition, is limited representation of both male female biological sexes available despite fact that sex significantly affects body development, especially highly dynamic population. As result, we developed Athena, realistic model...
Magnetic resonance imaging (MRI) and continuous electroencephalogram (EEG) monitoring are essential in the clinical management of neonatal seizures. EEG electrodes, however, can significantly degrade image quality both MRI CT due to substantial metallic artifacts distortions. Thus, we developed a novel thin film trace net ("NeoNet") for improved without compromising signal quality. The aluminum traces were fabricated with an ultra-high-aspect ratio (up 17,000:1, dimensions 30 nm × 50.8 cm...
We introduce a new EEG net, which will allow clinicians to monitor while tracking head motion for correction. Motion during MRI limits patient scans, especially of children and patients with seizures. The MotoNet was built using PTF, embedding EEG/motion sensor pairs on opposite sides in one circuit. safety studies at 3T confirmed maximum heating below 1ºC. measurements were made standard commercial system. Using custom sequence spatial localization gradients only, we showed that...