A5065261311- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Mycotoxins in Agriculture and Food
- Advanced Nanomaterials in Catalysis
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Glutathione Transferases and Polymorphisms
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Coccidia and coccidiosis research
- Nanoparticles: synthesis and applications
- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Insect Pest Control Strategies
- Phytochemistry and Biological Activities
- Advanced biosensing and bioanalysis techniques
- Peanut Plant Research Studies
- Trace Elements in Health
- Fungal Plant Pathogen Control
- Carcinogens and Genotoxicity Assessment
- Synthesis and Biological Evaluation
- Yeasts and Rust Fungi Studies
- Plant Disease Management Techniques
Oregon Health & Science University
2021-2025
University of Montana
2015-2021
Center for Environmental Health
2020-2021
University of Tehran
2008-2011
Islamic Azad University, Tehran
2011
Tarbiat Modares University
2006-2008
Abstract Senescence is a non-proliferative, survival state that cancer cells can enter to escape therapy. In addition soluble factors, senescence secrete extracellular vesicles (EVs), which are important mediators of intercellular communication. To explore the role senescent cell-derived EVs (senEVs) in inflammatory responses senescence, we developed an engraftment-based model wild-type mice and genetically blocked senEV release vivo, without significantly affecting mediators. SenEVs were...
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<div>Abstract<p>Senescence is a nonproliferative survival state that cancer cells can enter to escape therapy. In addition soluble factors, senescence secrete extracellular vesicles (EV), which are important mediators of intercellular communication. To explore the role senescent cell (SC)–derived EVs (senEV) in inflammatory responses senescence, we developed an engraftment-based model wild-type mice and genetically blocked senEV release <i>in vivo</i>, without...
Immunotherapy is an approved treatment option for head and neck squamous cell carcinoma (HNSCC). However, the response rate to immune checkpoint blockade only 13% recurrent HNSCC, highlighting urgent need better understand tumor-immune interplay, with ultimate goal of improving patient outcomes. HNSCC present high local recurrence rates therapy resistance that can be attributed presence cancer stem cells (CSC) within tumors. CSC exhibit singular properties enable them avoid detection...
Lysosomal membrane permeabilization (LMP) has been proposed to precede nanoparticle-induced macrophage injury and NLRP3 inflammasome activation; however, the underlying mechanism(s) of LMP is unknown. We propose that lysosomal hyperpolarization triggers LMP. In this study, a rapid non-invasive method was used measure changes in potential murine alveolar macrophages (AM) response series nanoparticles (ZnO, TiO2, CeO2). Crystalline SiO2 (micron-sized) as positive control. Changes cytosolic...
The natural occurrence of fungal contamination was evaluated in stored nuts including pistachio, peanut, hazelnut and almond selected randomly from different regions Tehran. After initial preparation, the samples were cultured on Sabouraud glucose agar, Dichloran rose-bengal agar Czapek-dox agar. A total 60 analyzed 158 isolates identified. Mycological analyses revealed that most frequent isolated fungi Aspergillus (32.2%), Penicillium (30.3%), Mucor (17.1%), Fusarium (18.2%), Paecilomyces...
SummaryHoney is well known to possess a broad spectrum of activity against medically important organisms. The purpose this study was investigate the anti-candidal 28 locally produced honeys from two floral sources, 14 southern and northern Iran, some pathogenic Candida species such as albicans, C. parapsilosis, tropicalis, kefyr, glabrata, dubliniensis. A microdilution broth method used assess selected six species. were tested at 40 concentrations ranging 20 60 % (v/v). Both possessed in...
Background: While the role of lysosomal membrane permeabilization (LMP) in NP-induced inflammatory responses has been recognized, underlying mechanism LMP is still unclear. The assumption that zinc oxide (ZnO)-induced due to Zn2+; however, little known about ZnO nanoparticles (NP) toxicity.Methods: We examined contribution intact NP on permeability using red blood cells (RBC) and undifferentiated THP-1 as models particle-membrane interactions simulate NP-lysosomal interaction. integrity...
Summary The effects of two Iranian medicinal plants including Zataria multiflora and Geranium pelargonium were evaluated on growth-inhibiting some toxigenic fungi such as Aspergillus flavus, A. parasiticus, ochraceus Fusarium verticillioides. In this study, standard Z. G. essential oils (EOs) diluted in 0.01% dimethyl sulfoxide. Different dilutions (500, 1000, 2000 4000 ppm) EOs (1000, 2000, 8000 along with 0.1 ml each fungal suspension inoculated onto sabouraud glucose agar incubated at...
ABSTRACT Tinea cruris is a subacute or chronic dermatophytosis. This report describes 30‐year‐old man presenting with history of bullous erythematous along itching his crural regions. On the basis clinical findings, lesions were diagnosed as contact dermatitis and pustular psoriasis, so he was treated by local systemic corticosteroids but progressed on affected sites. By using mycological histological examinations, dermatophytosis caused Trichophyton mentagrophytes var. confirmed. The...
Lymph nodes are key lymphoid organs collecting lymph fluid and migratory cells from the tissue area they survey. When cancerous arise within a tissue, sentinel node is first immunological organ to mount an immune response. Sub-capsular sinus macrophages (SSMs) specialized residing in that play important roles as gatekeepers against particulate antigenic material. In context of cancer, SSMs capture tumor-derived extracellular vesicles (tEVs), form antigen released high amounts by tumor cells....