A5037681895- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Cellular Mechanics and Interactions
- Bone Metabolism and Diseases
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Hip disorders and treatments
- Bone health and treatments
- Inflammatory mediators and NSAID effects
- Cell Adhesion Molecules Research
Shanghai Ninth People's Hospital
2019-2024
Shanghai Jiao Tong University
2019-2023
Abstract Titanium and titanium alloys are widely used in orthopedic implants. Modifying the nanotopography provides a new strategy to improve osseointegration of substrates. Filamentous actin (F-actin) polymerization, as mechanical loading structure, is generally considered be involved cell migration, endocytosis, division, shape maintenance. Whether F-actin how it functions nanotube-induced osteogenic differentiation mesenchymal stem cells (MSCs) remain elucidated. In this study, we...
To evaluate accuracy of an innovative "Skywalker" system, a newly designed, robot-assisted operation system for orthopaedics via clinical trial at knee joint. We conducted prospective analysis the data 31 patients who underwent total arthroplasty assisted by robot (Microport, Suzhou, China) from June 2020 to January 2021. Five male and 26 female aged 69.68 ± 6.11 years (range: 57-79 years) were diagnosed with osteoarthritis indicated surgery. The surgical robotic was adopted make...
Abstract Background Aspirin is a commonly used antipyretic, analgesic, and anti-inflammatory drug. Numerous researches have demonstrated that aspirin exerts multiple biological effects on bone metabolism. However, its spatiotemporal roles remain controversial according to the specific therapeutic doses for different clinical conditions, detailed mechanisms not been fully elucidated. Hence, in present study, we aimed identify dual of dosages osteoclastic activity osteoblastic formation vitro...
Bone integration on the surface of titanium prosthesis is critical to success implant surgery. Good at contact interface basis long-term stability. TiO2 nanotubes have become one most commonly used modification techniques for artificial joint prostheses and bone defect implants due their good biocompatibility, mechanical properties chemical can promote F-actin polymerization in mesenchymal stem cells (BMSCs) osteogenic differentiation. The possibility as an upstream part regulate GCN5...
Abstract Background Currently, robot‐assisted surgical systems are used to reduce the error range of total knee arthroplasty (TKA) osteotomy and component positioning. Methods We 20 sawbone models femur tibia fibula evaluate effect ‘Skywalker’ TKA. Results The maximal movement cutting jig was less than 0.25 mm at each plane. mean standard deviation values angle between planned plane actual were not more 1.03° 0.55°, respectively. absolute resection thickness position 0.78 0.71 mm,...
Preoperative planning is critical for total knee arthroplasty (TKA) performed with surgical robots, as it involves establishing a coordinate system to calculate the angle values of components. This serves reference during stage. study aimed develop newly custom suitable integration robot system.