A5047421180- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Pesticide Exposure and Toxicity
- Asthma and respiratory diseases
- Toxic Organic Pollutants Impact
- Heavy Metal Exposure and Toxicity
- Allergic Rhinitis and Sensitization
- Pregnancy and Medication Impact
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Immune Response and Inflammation
- Traumatic Brain Injury and Neurovascular Disturbances
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Climate Change and Health Impacts
- Oral microbiology and periodontitis research
- Birth, Development, and Health
- Environmental Toxicology and Ecotoxicology
- Dermatology and Skin Diseases
- Pesticide and Herbicide Environmental Studies
- Nitric Oxide and Endothelin Effects
- Noise Effects and Management
- Demographic Trends and Gender Preferences
- Cellular Mechanics and Interactions
Shanghai Jiao Tong University
2016-2025
International Peace Maternity & Child Health Hospital
2022-2025
Peking Union Medical College Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Army Medical University
2010-2024
Daping Hospital
2010-2024
Shanghai Children's Hospital
2019-2023
Shanghai Ninth People's Hospital
2018-2022
XinHua Hospital
2019-2022
Sun Yat-sen University
2013-2021
Psoralen and angelicin are two effective compounds isolated from psoraleae,a traditional Chinese medicine. They have a wide range of applications for bone disease treatment immune modulation. In this study, we explored their new the periodontal diseases. This study aimed to investigate effects psoralen on Porphyromonas gingivalis growth P. gingivalis-derived lipopolysaccharide (Pg-LPS)-induced inflammation, further evaluate osteogenesis. Finally, mouse model periodontitis were also...
Background: Pesticides have been associated with reproductive disorders, but there is limited research on pesticide exposures and human fertility. Objective: We aimed to investigate the effects of preconception exposure pesticides time pregnancy (TTP) infertility in a general population couples planning become pregnant Shanghai, China. Methods: A total 615 women who were enrolled before conception prospectively followed for 1 y observe their TTP. Preconception assessed by measuring urinary...
Periodontitis is one of the most common oral diseases and a potential risk factor for systemic diseases. In this study, we aimed to investigate association between periodontitis learning memory impairment.We established model by topical application Porphyromonas gingivalis lipopolysaccharide (P. gingivalis-LPS) into palatal gingival sulcus maxillary first molars 10-week-old male rats 10-week period. We assessed alveolar bone resorption using micro-computed tomography analysis ability Morris...
Abstract Background Increasing evidence suggests a causal link between periodontitis and cognitive disorders. Systemic inflammation initiated by may mediate the development of impairment. Our study aims to investigate effect ligature-induced on function role signal transducers activators transcription 3 (STAT3) in this process. Materials methods Ligature-induced was established, rats were treated intraperitoneally with/without pSTAT3 inhibitor cryptotanshinone (CTS). Alveolar bone resorption...
Childhood asthma and allergic diseases are a significant global problem. There inconsistent findings on the associations of delivery mode, number children in household breastfeeding with childhood diseases. We assessed these examined whether modified effects neonatal familial risk factors diseases.A population-based cross-sectional study was conducted Shanghai, China. A total 17 primary schools were randomly selected from 13 districts Shanghai this study. The International Study Asthma...
Background: Immunotherapy is effective in treating unresectable esophageal squamous cell carcinoma (ESCC), but little known about its role the preoperative setting. The aim of this study was to evaluate safety, feasibility and efficacy neoadjuvant treatment with camrelizumab plus chemotherapy locally advanced ESCC. Methods: Patients diagnosed ESCC were retrospectively included if they had received nab-paclitaxel S1 capsule followed by radical esophagectomy between November, 2019 June, 2020...
Studies have shown that permissive hypotension for uncontrolled hemorrhagic shock can result in good resuscitation outcome. The ideal target mean arterial pressure (MAP) and the tolerance time not been determined.To elucidate MAP with rats, effects of different MAPs (40, 50, 60, 70, 80, 100 mmHg) 60-, 90-, 120-min (50 on were observed.Rats normotensive groups (80 had increased blood loss (101%, 126% total volume), decreased hematocrit, vital organ (liver kidney) mitochondrial function,...
The calcium-sensing receptor (CaSR) plays a fundamental role in extracellular calcium homeostasis humans. Surprisingly, CaSR is also expressed nonhomeostatic tissues and involved regulating diverse cellular functions. objective of this study was to determine if Calhex-231 (Cal), negative modulator CaSR, may be beneficial the treatment traumatic hemorrhagic shock (THS) by improving cardiovascular function investigated mechanisms. Rats that had been subjected THS hypoxia-treated vascular...
Several medical conditions exhibit age- and sex-based differences. Whether or not traumatic shock exhibits such differences with regard to vascular responsiveness is clear. In a cohort of 177 healthy subjects 842 trauma patients (21–82 years) as well different ages (4, 8, 10, 14, 18, 24 wk; 1 1.5 sexes Sprague-Dawley normal rats, the underlying mechanisms were investigated. Middle-aged young women female rats reproductive age had higher in condition lower decrease after than older men male...
Abstract Titanium and titanium alloys are widely used in orthopedic implants. Modifying the nanotopography provides a new strategy to improve osseointegration of substrates. Filamentous actin (F-actin) polymerization, as mechanical loading structure, is generally considered be involved cell migration, endocytosis, division, shape maintenance. Whether F-actin how it functions nanotube-induced osteogenic differentiation mesenchymal stem cells (MSCs) remain elucidated. In this study, we...
Surface modification of titanium has been a hot topic to promote bone integration between implants and tissue. Titanium dioxide nanotubes fabricated on the surface by anodic oxidation have mature scheme that shown osteogenesis in vitro. However, mechanisms behind such phenomenon remain elusive. In this study, we verified enhanced BMSCs nanotopographic vitro proved its effect vivo constructing defect model rats. addition, role mechanosensitive molecule Yap is studied research application...
Abstract Background Sepsis is a life-threatening disease with poor prognosis, and metabolic disorders play crucial role in its development. This study aims to identify key metabolites that may be associated the accurate diagnosis prognosis of sepsis. Methods Septic patients healthy individuals were enrolled investigate changes using non-targeted liquid chromatography-high-resolution mass spectrometry metabolomics. Machine learning algorithms subsequently employed differentially expressed...
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide, especially in developed countries. Although patients' overall survival has been improved by either conventional chemotherapy or newly anti-angiogenesis treatment based on its highly vascularized feature, relatively low therapeutic efficacy and severe side effects remain big problems clinical practice. In this study, we describe an easy method to construct a novel matrix metalloproteinase-2 (MMP-2) responsive...