A5100452629- Plant-based Medicinal Research
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Chromatography in Natural Products
- Traditional Chinese Medicine Analysis
- Medicinal Plants and Bioactive Compounds
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ginseng Biological Effects and Applications
- Genomics, phytochemicals, and oxidative stress
- Rheumatoid Arthritis Research and Therapies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Alkaloids: synthesis and pharmacology
- Natural product bioactivities and synthesis
- Drug-Induced Hepatotoxicity and Protection
- Dermatologic Treatments and Research
- Alcohol Consumption and Health Effects
- Magnolia and Illicium research
- Bioactive Natural Diterpenoids Research
- Pharmacogenetics and Drug Metabolism
- Parathyroid Disorders and Treatments
- Mass Spectrometry Techniques and Applications
- Inorganic Fluorides and Related Compounds
- Receptor Mechanisms and Signaling
- Inhalation and Respiratory Drug Delivery
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Guang’anmen Hospital
2022-2023
Guangdong University of Technology
2023
First Affiliated Hospital of Henan University
2023
China Academy of Chinese Medical Sciences
2021-2022
Chengdu University of Traditional Chinese Medicine
2022
Institute of Chinese Materia Medica
2021
University of Science and Technology of China
2020
This study aimed to explore the pharmacological mechanism of Yourenji Capsules(YRJ) in improving osteoporosis by combining network pharmacology and proteomics technologies. The SD rats were randomly divided into a blank control group 700 mg·kg~(-1) YRJ group. subjected gavage administration with corresponding drugs, serum, drug-containing samples compared using ultra performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry(UPLC-Q-TOF-MS/MS) analyze main components...
This study aimed to investigate the main pharmacological action and underlying mechanisms of Jin Gu Lian Capsule (JGL) against rheumatoid arthritis (RA) based on network pharmacology experimental verification.Network approaches were performed explore core active compounds JGL, key therapeutic targets, signaling pathways. Molecular docking was used predict binding affinity with targets. In vivo experiments undertaken validate findings from analysis.A total 52 targets identified as candidate...
Background:A. chinense frequently used in Miao medicine to treat rheumatic diseases. However, as a famous toxic herb, Alangium and its representative components exhibit ineluctable neurotoxicity, thus creating significant challenges for clinical application. The combined application with compatible herbs Jin-Gu-Lian formula attenuates such neurotoxicity according the principle of traditional Chinese medicines. Purpose: We aimed investigate detoxification on A. chinense-induced mechanism....
Pulmonary fibrosis (PF) is a chronic, progressive, and often fatal interstitial lung disease. Traditional Chinese medicine formulations their active ingredients have shown potential in the treatment of PF. Panax notoginseng saponin (PNS) extracted from widely used traditional medicinal herb (Burkill) F. H. Chen, exhibiting therapeutic effects pulmonary diseases treatment.This study aimed to investigate elucidate possible mechanisms PNS on bleomycin (BLM)-induced PF rats.PF was induced rats...
Abstract A nickel‐catalyzed direct trifluoroethylation of aryl iodides with an industrial raw material CF 3 CH 2 I has been developed, demonstrating high efficiency, excellent functional‐group compatibility, especially large sterically hindered groups. The key to success is the combination nickel readily available nitrogen and phosphine ligands. powerful potential this strategy further demonstrated by late‐stage modification several derived bioactive molecules. magnified image
Panax ginseng C. A. Meyer (ginseng) is a widely used traditional Chinese medicine that has played beneficial role in the treatment of various diseases, including liver diseases. Ginsenoside Rg1 saponin isolated and purified from exerts protective effects on some injury models. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) ubiquitous dioxin found mostly food products causes other human Although significant efforts have been made to reduce burden disease, there still lack effective...
Systemic sclerosis (SSc; also known as "scleroderma") is an autoimmune disorder characterized by extensive fibrosis, vascular changes, and immunologic dysregulation. Baicalein (phenolic flavonoid derived from Scutellaria baicalensis Georgi) has been used to treat the pathological processes of various fibrotic inflammatory diseases. In this study, we investigated effect baicalein on major pathologic characteristics SSc: B-cell abnormalities, inflammation.The collagen accumulation expression...
Intestinal stem cells (ISCs) are the reservoir source of various types intestinal cells, and decline cell function in gut may be a potential factor for aging-related disease. The present study aimed to explore regulatory mechanisms Panax ginseng C.A.Meyer (Araliaceae, genus) that could restore aging by enhancing regulating ISCs mice based on Wnt/β-catenin signaling pathway.
Aconitine hydrolysis is deemed to be the guarantee for safe application of Aconitum phytomedicine. Studies have suggested that hydrolysates aconitine not only include benzoylaconitine and aconine, but other hydrolysates. Moreover, these maybe a mutual transformation relationship, which has been confirmed. Herein, their relationship were studied by theoretical quantum chemistry, UPLC-Q-TOF-MS, separation identification target products, etc. Then toxicity its was evaluated. The results...
This study aims to investigate the mechanism of Xueshuantong Injection(XST) on pulmonary fibrosis induced by bleomycin(BLM) in rats based coagulation cascade pathway. Sixty SD were randomly divided into sham surgery group,model group, pirfenidone(PFD, 50 mg·kg~(-1)) and 27, 54, 81 mg·kg~(-1) XST groups. The rat model was established intratracheal injection BLM(5 mg·kg~(-1)). After 24 hours, administration groups given corresponding drugs, while group equal volumes saline. On 28th day,...
The pathogenesis and treatment of cardiovascular disease mediated by chronic kidney (CKD) are key research questions. Specifically, the mechanisms underlying cardiorenal protective effect Yiqi-Huoxue-Jiangzhuo formula (YHJF), a traditional Chinese herbal medicine, have not yet been clarified.A classical CKD mouse model was constructed 5/6 nephrectomy (Nx) to study effects YHJF intervention on Nx mice function, gut microbial composition, gut-derived metabolites, NLRP3 inflammasome...
To avoid adverse drug reactions associated with injection, off-label nebulization of Tanreqing (TRQ) injection is often used in China to treat respiratory diseases. However, the aerodynamic properties and lung availability TRQ aerosols remain largely uninvestigated. This study aimed investigate size distribution compare pharmacokinetics tissue two compounds from (baicalin oroxyloside) after transnasal aerosol inhalation intravenous administration. Furthermore, this evaluate efficacy against...
Background: Rhizoma Dioscoreae bulbiferae could cause liver damage, which limited its application in the clinic. Aims and Objectives: To explore mechanism of hepatotoxicity mice. Materials Methods: In present study, water extraction (W.E.R) was administrated via intragastrical with Low (19.6 g/kg), Middle (28.0 High (40.0 g/kg) dose At each time point 14 days, 21 28 body weight, coefficient, indexes function alkaline phosphatase (ALP), alanine aminotransferase (ALT) aspartate transaminase...
The induction of cytochrome P450s can result in reduced drug efficacy and lead to potential drug–drug interactions. xenoreceptors—aryl hydrocarbon receptor (AhR), constitutive androstane (CAR), pregnane X (PXR)—play key roles CYP by xenobiotics. In order be able rapidly screen for the three enzymes (CYP1A1, CYP2B6, CYP3A4), we generated a stable AhR-responsive HepG2 cell line, CAR-responsive PXR-responsive line.To validate these xenoreceptor-responsive lines, evaluated different Gaussia...
Abstract This paper provides a rapid method coupled with chemometrics to visualise PEL quality of eight regions. The contents mineral elements, Vitamin C (Vc), and colour parameters were measured using spectrophotometric methods. volatile substances determined by electronic nose (E-nose) headspace solid phase micro-extraction gas chromatography-mass spectrometry (HS-SPME/GC-MS). Chemometric analyses employed the sample distribution according geographical origin. parameters, Vc, from diverse...
A liquid chromatography-tandem mass spectrometry method was established and validated for determining the concentrations of costunolide(CO), piperine(PI), agarotetrol(AG), glycyrrhizic acid(GL), vanillic acid(VA), glycyrrhetinic acid(GA) in rat plasma. This then applied to toxicokinetic study these six compounds rats with chronic cerebral ischemia(CCI) following multiple oral doses Zhachong Shisanwei Pills. Finally, effects continuous multiple-dose administration Pills on liver CCI were...
Aconiti Kusnezoffii Radix Cocta is one of the most commonly used medicinal materials in Mongolian medicine. Due to strong toxicity Cocta, medicine often uses Chebulae Fructus, Glycyrrhizae et Rhizoma reduce toxicity, so as ensure curative effect while ensuring its clinical effect, but mechanism not clear. The aim this study was investigate effects and on mRNA transcription protein translation cytochrome P450(CYP450) liver normal rats. Male SD rats were randomly divided into negative...
Two undescribed phenylpropenoid glycosides (1 - 2) and one known analogues (3) have been isolated identified from the roots of Illicium dunnianum. The structures these new compounds were elucidated by extensive spectroscopic analyses D-, 2 D-NMR, HRESIMS, IR, UV) chemical methods. anti-inflammatory activities all isolates evaluated measuring their inhibitory effects on PGE2 production in LPS stimulated RAW 264.7 macrophages.