A5018368792- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
University of Freiburg
2020-2022
University Medical Center Freiburg
2022
Institute of Virology of the Slovak Academy of Sciences
2021
In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected 31 countries. Phylogeographic analyses sequences obtained from national and international databases reveal a global spread through multiple introductions its inferred origin Western Africa. Variant is characterized mutational pattern spike gene that includes L18F, L452R N501Y amino...
Abstract Fc-gamma receptor (FcγR) activation by soluble IgG immune complexes (sICs) represents a major mechanism of inflammation in certain autoimmune diseases such as systemic lupus erythematosus (SLE). A robust and scalable test system allowing for the detection quantification sIC bioactivity is missing. Previously described FcγR interaction assays are limited to FcγRs, lack scalability flexibility, not indicative or sensitivity towards size. We developed comprehensive reporter cell panel...