A5081608088- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Animal Virus Infections Studies
- COVID-19 diagnosis using AI
- Biosensors and Analytical Detection
- Viral Infections and Outbreaks Research
- vaccines and immunoinformatics approaches
- HIV-related health complications and treatments
- Evolution and Genetic Dynamics
- Advanced Chemical Sensor Technologies
- Economic and Financial Impacts of Cancer
- Hemoglobinopathies and Related Disorders
- Global Cancer Incidence and Screening
- Complement system in diseases
- HIV Research and Treatment
- Vector-Borne Animal Diseases
- Malaria Research and Control
- Immune Cell Function and Interaction
- HIV/AIDS Research and Interventions
- Blood donation and transfusion practices
- Virology and Viral Diseases
- Clinical Laboratory Practices and Quality Control
- Sperm and Testicular Function
- Viral Infections and Vectors
Rwanda Biomedical Center
2020-2024
University of Rwanda
2020-2022
Ministry of Health
2020-2022
Quadram Institute
2022
Suppressing infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will probably require the rapid identification and isolation individuals infected with virus on an ongoing basis. Reverse-transcription polymerase chain reaction (RT-PCR) tests are accurate but costly, which makes regular testing every individual expensive. These costs a challenge for all countries around world, particularly low-to-middle-income countries. Cost reductions can be achieved by pooling (or...
In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected 31 countries. Phylogeographic analyses sequences obtained from national and international databases reveal a global spread through multiple introductions its inferred origin Western Africa. Variant is characterized mutational pattern spike gene that includes L18F, L452R N501Y amino...
Abstract COVID-19 transmission rates are often linked to locally circulating strains of SARS-CoV-2. Here we describe 203 SARS-CoV-2 whole genome sequences analyzed from in Rwanda May 2020 February 2021. In particular, report a shift variant distribution towards the emerging sub-lineage A.23.1 that is currently dominating. Furthermore, detection first Rwandan cases B.1.1.7 and B.1.351 variants concern among incoming travelers tested at Kigali International Airport. To assess importance viral...
A Rift Valley fever epizootic affected livestock in Rwanda during March-October 2022. We confirmed 3,112 infections with the virus, including 1,342 cases, 1,254 abortions, and 516 deaths among cattle, goats, sheep. recommend a One Health strategy for investigations response to protect animal human health.
Suppressing SARS-CoV-2 will likely require the rapid identification and isolation of infected individuals, on an ongoing basis. RT-PCR (reverse transcription polymerase chain reaction) tests are accurate but costly, making regular testing every individual expensive. The costs a challenge for all countries particularly developing countries. Cost reductions can be achieved by pooling (or combining) subsamples them in groups. We propose algorithm based geometry hypercube that, at low...
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for disease 19 (COVID-19), is a single-stranded positive-sense ribonucleic acid (RNA) virus that typically undergoes one to two single nucleotide mutations per month. COVID-19 continues spread globally, with case fatality and test positivity rates often linked locally circulating strains of SARS-CoV-2. Furthermore, in this virus, particular those occurring the spike protein (involved binding host...
The proper control of Plasmodium infection requires a finely balanced immune response. Here, we evaluated the implication TGF-β1 and TGF-β3 in this process using novel monoclonal antibodies to measure their plasma concentrations comparison with other cytokines expression FOXP3 mRNA. Plasma cytokine levels were measured 80 patients severe anaemic malaria 186 mild presentation ELISA, rtPCR was used mRNA expression. While no mature TGF-β isoforms detected plasma, latent strongly upregulated...
One of the lessons learned from coronavirus disease 2019 (COVID-19) pandemic is importance early, flexible, and rapidly deployable detection methods. Currently, diagnosis COVID-19 requires collection oro/nasopharyngal swabs, nasal turbinate, anterior nares saliva but as continues, methods that can identify infected individuals earlier more quickly will be crucial for slowing spread virus. Previous studies have indicated dogs trained to volatile organic compounds (VOCs) produced during...
Accurate diagnostic tests are essential to both support the management and containment of outbreaks, as well inform appropriate patient care. In case SARS-CoV-2 pandemic, antigen Rapid Diagnostic Tests (Ag-RDTs) played a major role in this function, enabling widespread testing by untrained individuals, at home within health facilities.
Objective To evaluate the use of antigen-based rapid diagnostic tests (Ag-RDTs) alongside a digital tool to deliver household-level COVID-19 testing by community health workers (CHWs), in line with Rwanda’s ambition decentralise testing. Design This was an operational pilot study impact and characteristics using e-ASCov combined Ag-RDTs support symptom screening CHWs across eight districts Rwanda. A total 800 selected from both rural urban areas were trained delivering for e-ASCOV...
Objectives Reverse transcriptase PCR is the most sensitive test for SARS-CoV-2 diagnosis. However, scale-up of these tests in low-income and middle-income countries (LMICs) has been limited due to infrastructure cost. Antigen rapid diagnostic are an alternative option diagnosing active infection that may allow faster, easier, less expensive more widespread testing. We compared implementation antigen testing programmes Rwanda. Design retrospectively reviewed routinely collected data all...
Background
 Infertility remains a highly prevalent global condition in the second decade of new millennium. Reproductive hormones determine sperm quality as they initiate and maintain spermatogenesis. Hormonal imbalance can cause abnormal that be treated by hormonal replacement therapy.
 Objective
 To assess relationship between male reproductive among partners with fertility complications attending CHUB.
 Methods
 The study was descriptive cross-sectional,...
In rural sub-Saharan Africa, access to care for severe non-communicable diseases (NCDs) is limited due myriad delivery challenges. We describe the implementation, patient characteristics, and retention rate of an integrated NCD clinic inclusive cancer services at a district hospital in Rwanda.In 2006, Rwandan Ministry Health Rwinkwavu District Hospital (RDH) Partners established focused on nurse-led NCDs, within single platform. Implementation modifications were made 2011 include services....
Suppressing SARS-CoV-2 will likely require the rapid identification and isolation of infected individuals, on an ongoing basis. RT-PCR (reverse transcription polymerase chain reaction) tests are accurate but costly, making regular testing every individual expensive. The costs a challenge for all countries particularly developing countries. Cost reductions can be achieved by combining samples them in groups. We propose algorithm grouping subsamples, prior to testing, based geometry hypercube....
Abstract The emergence of the SARS-CoV-2 Delta variant concern (lineage B.1.617.2) in late 2020 resulted a new wave infections many countries across world, where it often became dominant lineage relatively short amount time. We here report on novel genomic surveillance effort Rwanda time period from June to September 2021, leading 201 genomes being generated, majority which were identified as concern. show that Rwanda, almost completely replaced previously A.23.1 and B.1.351 (Beta) lineages...
Abstract In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected 31 countries. Phylogeographic analyses sequences obtained from national and international databases reveal a global spread through multiple introductions its inferred origin Western Africa. Variant is characterized mutational pattern spike gene that includes L18F, L452R...
Abstract Background: Cytokines network drive Human Immunodeficiency Virus (HIV) inflammation and pathogenesis. Highly Active Antiretroviral Therapy (HAART) maintains low HIV viral load (VL) but chronic remains high in subjects compared to naïve population. To date, there is no surrogate biomarker that gives the hallmark picture of immune activation, programs. This study aimed at determining plasma cytokine levels their association with VL initiation after six months on HAART Rwanda. Methods:...