A5091259009- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Fungal Infections and Studies
- Bacterial Infections and Vaccines
- Diverse Scientific Research Studies
- Healthcare Systems and Reforms
- Long-Term Effects of COVID-19
- IgG4-Related and Inflammatory Diseases
- Malaria Research and Control
- Antifungal resistance and susceptibility
- Global Maternal and Child Health
- Complement system in diseases
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Inflammasome and immune disorders
- Pneumonia and Respiratory Infections
- Immune Cell Function and Interaction
- Global Public Health Policies and Epidemiology
UCLouvain
2022-2024
University of Rwanda
2020-2024
de Duve Institute
2022-2023
Abstract Background Gastric cancer is the sixth most frequently diagnosed and third in causing cancer-related death globally. The mutated gene human cancers TP53 , which plays a pivotal role initiation progression. In Africa, particularly Rwanda, data on mutations are lacking. Therefore, this study intended to obtain mutation status Rwandan patients with gastric cancer. Results Formalin-fixed paraffin-embedded tissue blocks of 95 histopathologically proven carcinoma were obtained from...
The proper control of Plasmodium infection requires a finely balanced immune response. Here, we evaluated the implication TGF-β1 and TGF-β3 in this process using novel monoclonal antibodies to measure their plasma concentrations comparison with other cytokines expression FOXP3 mRNA. Plasma cytokine levels were measured 80 patients severe anaemic malaria 186 mild presentation ELISA, rtPCR was used mRNA expression. While no mature TGF-β isoforms detected plasma, latent strongly upregulated...
Mutations in the TP53 tumor suppressor gene are well-established drivers of colorectal cancer (CRC) development. However, data on prevalence variants and their association with consensus molecular subtype (CMS) classification patients CRC from Rwanda currently lacking. This study addressed this knowledge gap by investigating mutation status concerning CMS a cohort Rwanda. Formalin-fixed paraffin-embedded (FFPE) tissue blocks were obtained 51 at University Teaching Hospital Kigali, Exons 4 to...
For effective treatments and preventive measures against severe COVID-19, it is essential to determine early markers of disease severity in different populations. We analysed the cytokine kinetics 129 COVID-19 patients with mild symptoms, 68 cases, 20 healthy controls for first time Rwanda. Pro-inflammatory (IFNγ, IL-6, TNFα), Treg (IL-10, TGFβ1, TGFβ3), Th9 (IL-9), Th17 (IL-17), Th2 (IL-4, IL-13) cytokines, total IgM IgG, as well gene expressions FoxP3, STAT5+, IFNγ-R1, ROR alpha+, were...
Background: Candida albicans still major leading global health challenge especially in immunocompromised individual particularly living low-income countries with limited access to the antifungal drugs. Though incidences and prevalence of opportunistic infection have been reduced due availability strict adherence antiretroviral therapy, candidiasis remains most frequent fungal high morbidity mortality It is a neglected topic research sectors developing world including Rwanda. This study aimed...
Background: Cerebrospinal meningitis is an important cause of morbidity and mortality globally, but its highest burden in sub-Saharan Africa. Surveillance critical to assess the disease provide necessary information mitigate impact. The aim this study cases occurring across Rwanda order determine where illness lies, causative agents effective treatments.Method: A retrospective was carried out from January 2010 December 2016. 173 cerebrospinal fluid samples 25 Districts Hospitals were...
Background: In response to the need for interventions that facilitate accessibility of medical services in poor communities, an outreach activity was organized semi-rural areas Maraba and Simbi sectors located Huye district, Southern province Rwanda. The undertaken by health sciences students involved screening hypertension, risk diabetes, hepatitis, anemia, eye disease, HIV.Methods: Clinical assessments rapid laboratory diagnostic assays were used screen invited residents from two selected...
Background: Malaria is a leading cause of mortality and morbidity in sub-Saharan Africa including Rwanda. Though the prevalence malaria has been reduced due to use indoor residual sprayings insecticide-treated bed nets, it still disease that kills many people annually. Many studies conducted revealed Rwanda there high Plasmodium falciparum. However, gap identification presence mixed infection. This study was determine overall species as well plasmodium infection Ruhango Kibilizi Health...