A5074702551- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac Imaging and Diagnostics
- RNA Research and Splicing
- Neuroblastoma Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Chromatin Remodeling and Cancer
- Atherosclerosis and Cardiovascular Diseases
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Nuclear Structure and Function
- Traumatic Brain Injury and Neurovascular Disturbances
- Infectious Encephalopathies and Encephalitis
- Multiple Sclerosis Research Studies
- Neurological Disease Mechanisms and Treatments
- AI in cancer detection
- Cancer Mechanisms and Therapy
- Prenatal Screening and Diagnostics
- RNA regulation and disease
- Tumors and Oncological Cases
- Neurofibromatosis and Schwannoma Cases
- Cerebrovascular and genetic disorders
- Cardiovascular Health and Disease Prevention
King Abdulaziz University
2016-2025
Saudi Commission for Health Specialties
2024
King Faisal Specialist Hospital & Research Centre
2024
Western University
2013-2024
Children's Hospital of Los Angeles
2020-2024
Neurological Surgery
2024
University of Southern California
2020-2024
London Health Sciences Centre
2013-2022
British Columbia Children's Hospital
2019
Uppsala University
2019
The role of non-coding regulatory elements and how they might contribute to tissue type specificity disease phenotypes is poorly understood. Autosomal Dominant Leukodystrophy (ADLD) a fatal, adult-onset, neurological disorder that characterized by extensive CNS demyelination. Most cases ADLD are caused tandem genomic duplications involving the lamin B1 gene (LMNB1) while small subset deletions upstream gene. Utilizing data from recently identified families carry LMNB1 but do not exhibit...
Clinical, radiologic, and molecular analysis of patients with genomic deletions upstream the LMNB1 gene.Detailed neurologic, MRI examinations, custom array comparative hybridization (aCGH) analysis, expression were performed in at different clinical centers. All procedures approved by institutional review boards respective institutions.Five from 3 independent families presented ages ranging 32 to 52 years neurologic symptoms that included progressive hypophonia, upper lower limb weakness...
The underlying pathological process of “ischemic leukoencephalopathy” is not well studied in humans and “demyelination” thought to represent a major component. We selected brains from autopsy cases with definite histories recent cardiac arrest, which the findings demonstrated gray matter ischemic changes consistent survival time. excluded clinical or evidence other diseases that may affect white matter, specifically those moderate‐severe edema. were then subjected review gross pathology...
The pathologic features of adult-onset leukoencephalopathy/leukodystrophy with axonal spheroids (ALAS) are variable, and this has led to different hypotheses as whether primarily demyelination or axonopathy may underlie disorder. Typical ALAS pathology is rarely accompanied by focal multiple sclerosis (MS)-like plaques. In plaques cases, the cannot be distinguished from those progressive MS diffusely abnormal white matter. To clarify these issues, we examined neuropathologic in 159...
Adult-onset leukodystrophies are clinically and pathologically heterogeneous diseases, the overlapping morphologic features among these disorders can lead to confusion in pathologic classification. We report 3 recent autopsy cases that illustrate clinico-pathologic distinction between entities. The first, autosomal dominant leukodystrophy, is characterized by early autonomic dysfunction genetically LMNB1 (lamin B1 gene) duplication. Recently, another clinical subtype emerged without but with...
The histopathological features of leucoencephalopathy caused by illicit drugs (such as opioids and cocaine) are well documented in acute cases but not long-survival cases. There several hypotheses about the pathogenesis this disorder, including hypoperfusion, direct drug toxicity resulting from neurotoxic effects itself or contaminants vehicle. We reviewed post mortem findings five males (aged 24 to 56 years, with survival intervals ranging 7 days 5 months) a history use concomitant fatal...
Background Intravascular lymphoma (IVL) is a rare subtype of large-cell non-Hodgkin lymphoma, characterized by proliferation cells within the lumina small vessels. There are no previously reported cases IVL involving pituitary gland presenting with neuro-ophthalmic findings. Methods A 68-year-old female presented headache, right third nerve palsy, and Horner syndrome. MRI showed 1.4-cm sellar mass consistent macroadenoma. Two weeks later, despite treatment dexamethasone, patient developed...
<h3>Objectives:</h3> To elucidate the relationship between DNA methylation profiling (DMP) and pathological diagnosis (PD) in pediatric glial glioneuronal tumors with B-Raf proto-oncogene, serine/threonine kinase <i>(BRAF)</i> mutations, addressing their diagnostic challenges. <h3>Methods:</h3> This retrospective study, conducted Saudi Arabia, analyzed 47 cases from Children's Brain Tumor Network online database using scanned images, next-generation sequencing data, profiles processed...
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We report the first known case of an adrenal teratoma containing a Wilms tumor component, in 12-month-old girl with Trisomy 21. Despite teratomas being relatively uncommon, this particular instance raises interesting questions regarding origin, given coexistence both and tumor. Two main theories development have been hypothesized, one which suggests that may develop from primary other proposing could originate Our study leans toward former, as majority displayed characteristics typical...
Glioma can be classified according to its infiltrative capacity into circumscribed and "diffuse"/infiltrative glioma. Pilocytic astrocytoma is typically grouped under the astrocytic glioma in 2021 World Health Organization (WHO) classification of central nervous system (CNS) tumors. The distinction pilocytic from diffuse fundamental as it could difference between CNS WHO grade 1 4 This study aims determine nature different brain locations. All cases diagnosed "pilocytic astrocytoma" were...
Ganglioglioma is a well-circumscribed low-grade glioneuronal tumor with broad morphological spectrum. Diffuse tumors are used to describe cases infiltrative growth. Molecular studies of some these consistent ganglioglioma. This work aimed clarify the growth patterns in The available slides and clinical molecular information for 46 patients (50 samples) diagnosis ganglioglioma under open pediatric brain atlas from children's network database were reviewed confirm integrated evaluate cases....
Background It can be challenging to recognize undifferentiated/immature ganglion cells, especially single forms. Ganglion cells and glia are derived from enteric neural crest (ENCCs), a group of autonomic nervous system (ANS)-lineage progenitors that PHOX2B regulates. Phox2b is an excellent marker for neoplastic non-neoplastic ANS (eg, peripheral neuroblastic tumors [pNTs]). We hypothesized immunohistochemical staining (IHC) would also useful detecting ENCCs. Methods Hematoxylin eosin,...
This study adopts an innovative approach to utilize the DNA methylation class (MC) by prioritizing understanding of discrepancies over traditional direct comparisons with pathological diagnosis (PD). The aim is clarify morphological criteria for pleomorphic xanthoastrocytoma (PXA). Using Children's Brain Tumor Network online database, PXA-diagnosed cases were sourced. MCs and CDKN2A/B statuses ascertained using Heidelberg brain tumor classifier v12.5 (v12.8 selected cases). Three distinct...
Paired-like homeobox 2b (PHOX2B) is an established immunomarker for peripheral neuroblastoma and autonomic nervous system cells. We aimed to evaluate the utility of PHOX2B immunostaining in central (CNS) tumors with embryonal morphology. Fifty-one were stained submitted whole slide image analysis: 35 CNS morphology (31 four gliomas); 16 neuroblastomas included comparison. Diffuse nuclear immunopositivity was observed all (16/16) (primary metastatic). Among tumors, focal immunoreactivity most...
Pilocytic astrocytoma with a predominant oligodendrocyte-like component can be difficult to distinguish from oligodendroglioma, dysembryoplastic neuroepithelial tumors (DNTs), central neurocytoma, and ependymoma (clear cell phenotype). The utility of GFAP immunostaining in this context is not well discussed. All cases diagnosis pilocytic were retrieved the pathological archives along following information: age, sex, description. was scored as score 1 (<25%), 2 (25−50%), 3 (50−75%), 4 (>75%)....