A5101808857- Amyotrophic Lateral Sclerosis Research
- Epilepsy research and treatment
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Effects and Toxicity Studies
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Cholinesterase and Neurodegenerative Diseases
- Histone Deacetylase Inhibitors Research
- Alzheimer's disease research and treatments
- Glioma Diagnosis and Treatment
- Pancreatic function and diabetes
- Metabolism and Genetic Disorders
- Atrial Fibrillation Management and Outcomes
- Chemokine receptors and signaling
- Genetic Neurodegenerative Diseases
- Prion Diseases and Protein Misfolding
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Phagocytosis and Immune Regulation
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
Linyi People's Hospital
2014-2024
Health Commission of Anhui Province
2023
Xuzhou Medical College
2023
Shandong University
2018-2020
// Yonglei Liu 1, 2 , Jingling Zhang 1 Xiangjun Sun 3 Quanping Su and Cuiping You Research Center, Linyi People’s Hospital, Shandong, China Zhongshan Fudan University, Shanghai, Department of Surgery, Correspondence to: Liu, email: yongleiliu@yeah.net Keywords: breast cancer, miR-29b, fibroblasts, CCL11, CXCL14 Received: March 22, 2016 Accepted: February 27, 2017 Published: April 16, 2017 ABSTRACT Carcinoma associated...
Abstract CD44, a cell adhesion protein, involves in various process cancer such as survival and metastasis. Most researches on CD44 focus cells. Recently, it is found that expression high fibroblasts of tumour microenvironment. However, its role communication between breast cells seldom known. In this study, CD44‐positive (CD44 + Fbs) CD44‐negative carcinoma‐associated − were isolated cocultured with for analysis drug resistance. We Fbs promoted paclitaxel resistance inhibited...
Amyotrophic lateral sclerosis (ALS) is one of the most common neurodegenerative disorders, but no definite mechanism has been defined on loss motor neurons in ALS and currently therapy can block its progression. Many lines evidence indicate that there a disorder iron homeostasis ALS, thus we sought to test level patients by susceptibility weighted imaging (SWI). Sixteen 16 healthy persons underwent brain scans using SWI with 3T Siemens MR scanner. The red nucleus, substantia nigra, globus...
Head and neck cancer (HNC) is the fifth most common worldwide. In this study, we performed an integrative analysis of discovery set established eight-gene signature for prediction prognosis in patients with head squamous cell carcinoma (HNSCC). Univariate Cox was used to identify prognosis-related genes (with P < 0.05) GSE41613, GSE65858, TCGA-HNSC RNA-Seq datasets after data collection. We LASSO regression identified eight (CBX3, GNA12, P4HA1, PLAU, PPL, RAB25, EPHX3, HLF) non-zero...
Tyrosine kinase inhibitors (TKIs) are first-line therapies for hepatocellular carcinoma (HCC), but the drug resistance restricts long-term clinical outcomes. This study aimed to investigate expression patterns and possible significance of a TKI-resistant gene zeste white 10 (ZW10) in HCC. Clustered regularly interspaced short palindromic repeats (CRISPR) screening was conducted obtain genes. Pan-cancer analysis employed analyze landscape critical ZW10. Transcriptional data ZW10 were obtained...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons and lacks an effective treatment. The pathogenesis has not been clarified at present. Pathological transactive response DNA-binding protein 43 (TDP-43) plays important role in the of ALS. Nuclear translocation nuclear factor erythroid 2 (NF-E2)-related (Nrf2) found mutant TDP-43 transgenic cell model, but its downstream antioxidant enzyme expression decreased. To elucidate specific mechanism...
Dominant mutations in superoxide dismutase 1 (SOD1) are a frequent cause of the lethal neurodegenerative disease amyotrophic lateral sclerosis (ALS). The nuclear factor erythroid 2‑related 2 (Nrf2)/antioxidant response element (ARE) signaling pathway is major cellular defense mechanism against oxidative stress, however, its role ALS remains to be fully elucidated. Therefore, present study aimed investigate whether human SOD1-G93A gene affected Nrf2/ARE an cell model. soma became round and...
Abstract Background PCDH19 has become the second most relevant gene in epilepsy after SCN1A . Seizures often provoked by fever. Methods We screened 152 children with fever‐sensitive for detection. Their clinical information was followed up. Results found eight point mutations (four novel and four reported) one whole deletion 10 female probands (seven sporadic cases three family cases) who also had cluster seizures. The common features of 16 patients families included seizures, mainly focal...
Angiogenesis plays an important role in tumor initiation and progression of glioma. Seeking for biomarkers associated with angiogenesis is enhancing our understanding glioma biologically identifying its new drug targets. RNA-sequencing (RNA-seq) data matched clinical were downloaded from the CGGA database. A series filtering analyses performed to screen reliable genes: survival, multivariate Cox, ROC curve filtration, correlation analyses. After immunohistochemical verification, RAB42 was...
Purpose . The efficacy of valproic acid (VPA) varies widely in clinical treatment epileptic patients. Our study is aimed at exploring a potential association between polymorphisms SCN1A, SCN2A, and UGT2B7 genetic factors VPA responses. Methods In this observational study, total 114 patients only treated with for least 1 year were included to explore the drug responses (mean follow-up time: <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Chemotherapy remains the mainstay of treatment for lymphoma patient population, despite its relatively poor therapeutic results, high toxicity, and low specificity. With advancement biotechnology, significance drug-loading biomimetic materials in medical field has become increasingly evident, attracting extensive attention from scientific community pharmaceutical industry. Given that they can cater to particular requirements patients, have recently a potent promising delivery approach...
Accumulating evidence suggests that iron homeostasis is disordered in amyotrophic lateral sclerosis (ALS). In view of the promising performance epigallocatechin‑3‑gallate (EGCG) neuroprotection studies, present study aimed to verify whether EGCG protects motor neurons an ALS model, and it has any effects on metabolism using ELISA western blotting. The results demonstrated decreased oxidative stress protected organotypic culture rat spinal cord. Furthermore, total levels increased...
To figure out which diagnosis is more suitable and antiepileptic drugs are sensitive to epileptic negative myoclonus (ENM) as the first seizure type in atypical benign epilepsy with centrotemporal spikes.We reviewed electroencephalogram (EEG) database of Linyi People's Hospital Affiliated Shandong University medical records patients ENM onset. The characteristics seizures, onset age, treatment process, growth development history, past disease family degree mental deterioration, cranial...
We examined synergistic effects of inhibiting reactive oxygen species generated from the mitochondria and nicotinamide adenine dinucleotide phosphate oxidase on neurotoxicity. Primary hippocampal neurons were exposed to amyloid β, cells treated with diazoxide or/and diphenyleneiodonium chloride. found that cell viability was decreased significantly after exposure β for 72 h higer malondialdehyde levels, higher caspase-3 cleaved levels lower B-cell lymphoma 2 (Bcl-2) level. Both increased by...
Objective To investigate the effect of transfection hSOD1-G93A on expression iron-related proteins in NSC-34 cells. Methods The cell lines from four groups (without or stably transfected with pcDNA3.1(-), hSOD1-pcDNA3.1(-) and hSOD1-G93A-pcDNA3.1(-) plasmids) were cultured at routine ways. Morphological changes cells observed by immuno- histochemical method. The oxidative damage degrees detecting malondialdehyde content cells. Real time-PCR was used to determine mRNA levels iron-...
Epilepsy is a common and chronic neurological disease with high degree of genetic heterogeneity. The etiology pathogenesis the have not been fully understood. Many studies suggested that there was reciprocal relationship between mitochondrial dysfunction epilepsy, but few focused on genome (mtDNA) epilepsy patient which extremely important for function. In our study, we obtained complete mtDNA sequences 27 idiopathic patients healthy people, compared sequence data 30,000 GenBank including...