A5075289507- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Neurological diseases and metabolism
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Hereditary Neurological Disorders
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Amyotrophic Lateral Sclerosis Research
- Epilepsy research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Trypanosoma species research and implications
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Peripheral Neuropathies and Disorders
- Mitochondrial Function and Pathology
- Radiomics and Machine Learning in Medical Imaging
- Intracranial Aneurysms: Treatment and Complications
- Esophageal Cancer Research and Treatment
- Glioma Diagnosis and Treatment
- Autoimmune Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Immune cells in cancer
- Bone Metabolism and Diseases
Linyi People's Hospital
2015-2025
Weifang Medical University
2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2024
Guangzhou University of Chinese Medicine
2024
Xuzhou Medical College
2024
Qingdao University
2021-2023
Shandong University
2011-2022
Shandong First Medical University
2022
Shandong Provincial Hospital
2014-2017
Jiangjin Central Hospital
2015
Interleukin (IL)-37, a new IL-1 family member, has received increasing attention in recent years. In the past decade, it been determined that IL-37 is expressed various normal cells and tissues regulated by inflammatory stimuli pro-cytokines via different signal transduction pathways. Recently, found variety of cancers, chronic autoimmune disorders, exerts anti-inflammatory effects. Moreover, growing body literature demonstrates plays vital role inhibiting both innate adaptive immune...
Amyotrophic lateral sclerosis (ALS) is one of the most common neurodegenerative disorders, but no definite mechanism has been defined on loss motor neurons in ALS and currently therapy can block its progression. Many lines evidence indicate that there a disorder iron homeostasis ALS, thus we sought to test level patients by susceptibility weighted imaging (SWI). Sixteen 16 healthy persons underwent brain scans using SWI with 3T Siemens MR scanner. The red nucleus, substantia nigra, globus...
Abstract Objective To summarize the clinical features and genetic mutation characteristics of Chinese children with KCNQ2 ‐related epilepsy. Methods A cohort genetically caused epilepsy was evaluated at Linyi People's Hospital from January 2017 to December 2023. After next‐generation sequencing pathogenicity analysis, we summarized medical records testing data who had gene mutations. Results We identified 23 73.9% ( n = 17) sites were located in S5–S6 segments C‐terminal region. In addition...
Objective The study explores the association between inflammation/nutrition-based indicators, Parkinson’s disease (PD), and all-cause mortality among adult participants. Methods analysis included 38,091 participants from National Health Nutrition Examination Survey (NHANES) 1999–2018. Inflammation/nutrition-based indicators were derived a comprehensive set of parameters, including neutrophil-albumin ratio (NAR), prognostic nutritional index (PNI), monocyte-albumin (MAR), red cell...
Epalrestat (EPS), an aldose reductase inhibitor, is used to alleviate peripheral nerve disorder of diabetic patients in clinical therapy. Even though EPS exerted effects central nervous system diseases, the neuroprotection and underlying molecular mechanism neurodegenerative especially Parkinson's disease (PD), remains obscure. Our study aimed investigate potential suppressed PD progression both vivo vitro. We 1-methyl-4-phenylpyridillium ion (MPP+)-treated cells...
Propionic acid (PPA) is a critical metabolite involved in microbial fermentation, which functions to reduce fat production, inhibit inflammation, and serum cholesterol levels. The role of PPA the context cerebral ischemia-reperfusion (I/R) injury has yet be clarified. Increasing evidence indicate that transcranial direct-current stimulation (tDCS) safe approach confers neuroprotection ischemia injury. Here, we show levels were reduced ischemic brain following rat I/R cultured cortical...
Dominant mutations in superoxide dismutase 1 (SOD1) are a frequent cause of the lethal neurodegenerative disease amyotrophic lateral sclerosis (ALS). The nuclear factor erythroid 2‑related 2 (Nrf2)/antioxidant response element (ARE) signaling pathway is major cellular defense mechanism against oxidative stress, however, its role ALS remains to be fully elucidated. Therefore, present study aimed investigate whether human SOD1-G93A gene affected Nrf2/ARE an cell model. soma became round and...
Amyloid protein can damage nerve cells through a variety of biological mechanisms including oxidative stress, alterations in calcium homeostasis, and proapoptosis. Edaravone, potent free radical scavenger possessing antioxidant effects, has been proved neuroprotective effect stroke patients. The current study aimed to investigate the effects EDA an A β -induced rat model AD, by studying 1–40 voltage-gated channel currents hippocampal CA1 pyramidal neurons, learning memory behavioral tests,...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. The mechanism that defines the loss of neurons in ALS still not clearly understood, and there no effective therapy to block its progression. Previous studies indicate disorder iron homeostasis exists based on this, change serum ferritin association between metabolism clinical features Chinese Han patients with was further investigated present study, order define pathogenesis. Two cohorts were established: An group consisting...
AbstractObjectives. We explored the association between BDNF Val66Met polymorphism and susceptibility to both obsessive–compulsive disorder (OCD) Tourette syndrome (TS) in Chinese Han population. Methods. Genotyping for was performed 321 OCD patients 426 healthy control subjects case–control study data were analysed. Additionally, we evaluated genetic contribution of this variant 331 TS (including 267 trios) 519 controls using transmission disequilibrium test (TDT) study. Results. A...
Purpose . The efficacy of valproic acid (VPA) varies widely in clinical treatment epileptic patients. Our study is aimed at exploring a potential association between polymorphisms SCN1A, SCN2A, and UGT2B7 genetic factors VPA responses. Methods In this observational study, total 114 patients only treated with for least 1 year were included to explore the drug responses (mean follow-up time: <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...