Jonathon Cordova

ORCID: 0000-0003-4924-4703
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About
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Research Areas
  • Spinal Cord Injury Research
  • Stroke Rehabilitation and Recovery
  • Acute Lymphoblastic Leukemia research
  • Muscle activation and electromyography studies
  • Protein Degradation and Inhibitors
  • Cancer Genomics and Diagnostics
  • Melanoma and MAPK Pathways
  • Pancreatitis Pathology and Treatment
  • Pancreatic and Hepatic Oncology Research
  • Cancer therapeutics and mechanisms
  • Genetics, Bioinformatics, and Biomedical Research
  • Gastrointestinal disorders and treatments

University of New Mexico
1998-2024

Abstract Drug resistant mutations that arise in therapeutic targets often limit clinical responses. However, the discovery of such has historically been performed one gene or mutation at a time, over decades experimental and testing, limiting our understanding conserved mechanisms drug resistance. We hypothesized deep mutational scanning canonical kinases may expedite this process identify novel elements cause resistance when mutated (similar to well-studied “Gatekeeper” residue). To test...

10.1158/1538-7445.am2018-1815 article EN Cancer Research 2018-07-01
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