A5028990753- Fluorine in Organic Chemistry
- Synthesis and Biological Evaluation
- Immune Response and Inflammation
- Pain Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Porphyrin Metabolism and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Cytokine Signaling Pathways and Interactions
- Folate and B Vitamins Research
- Graphene and Nanomaterials Applications
- Psidium guajava Extracts and Applications
- HIV Research and Treatment
- Nerve injury and regeneration
- Blood Pressure and Hypertension Studies
- Immunotherapy and Immune Responses
- Phytochemistry and Biological Activities
- Multiple Sclerosis Research Studies
- RNA Interference and Gene Delivery
- Neuropeptides and Animal Physiology
- Inorganic Fluorides and Related Compounds
- Pharmacology and Obesity Treatment
- Chronic Kidney Disease and Diabetes
Kumamoto University
2023-2024
University of Rajshahi
2024
UNSW Sydney
2019-2023
Government Unani and Ayurvedic Degree College and Hospital
2021
South Western Sydney Local Health District
2021
Kyushu University
2017-2020
Graduate School USA
2017-2020
Square Hospitals
2020
University of Asia Pacific
2019
University of Dhaka
2019
The electrochemical trifluoromethylation and perfluoroalkylation of aromatic compounds mediated by a vitamin B<sub>12</sub> derivative as cobalt-based catalyst has been developed.
Multiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disease of the central nervous system. It was previously shown that toll-like receptor (TLR)-2 signaling plays a key role in murine experimental autoimmune encephalomyelitis (EAE) model MS, and TLR2-stimulation regulatory T cells (Tregs) promotes their conversion to helper 17 (Th17) cells. Here, we sought potential sources TLR2 stimulation evidence activity MS patient clinical samples. Soluble (sTLR2) found be...
Suppression of SARS-COV-2 based on the pH a GO dispersion is reported. At higher GO, overall surface charge more negative and with large number OH functional groups shows better SARS-CoV-2 inactivation.
Abstract The synthesis of difluoromethylated (CF 2 R) (R=H, alkyl/aryl, CO R, etc.) compounds has received considerable attention in recent years. In this study, the cobalt(III)−carbon‐mediated catalytic C−H difluoroacylation unactivated arenes and heteroarenes using BrCF Et is reported. This cycle based on a valence change cobalt catalyst, naturally derived vitamin B 12 derivative, driven by controlled‐potential electrolysis at −0.8 V vs. Ag/AgCl under visible‐light irradiation dimethyl...
Purpose To describe the clinical presentation and outcome of two cases with presumed non-Acanthamoeba amebic keratitis. Methods Case reports. Results Both patients presented typical symptoms signs Acanthamoeba The patients' soft contact lenses, lens cases, open solutions, conjunctival samples were cultured. Diagnosis keratitis was based on presence growth from lenses affected eyes. Amebic culture contralateral negative. Vahlkampfia cysts identified in case 1, Naegleria 2. Topical treatment...
Peripheral neuropathy (PN) is a debilitating complication of diabetes that affects >50% patients. Recent evidence suggests obesity and metabolic disease, which often precede diagnosis, may influence PN onset severity. We examined this in translationally relevant model prediabetes induced by cafeteria (CAF) diet Sprague–Dawley rats (n = 15 CAF versus n control). Neuropathy phenotyping included nerve conduction, tactile sensitivity, intraepidermal fiber density (IENFD) excitability testing,...
A sandwich immunosensor was successfully developed for monitoring of interleukin-1β (IL-1β) in rat whole blood. The substrate stainless steel (SS) first coated with a polydopamine layer and subsequently grafted poly(ethylene glycol) methacrylate brushes, onto which modified detection IL-1β. device has been applied IL-1β limit 4.7 pg mL-1, linear range 12.5-200 mL-1. Good specificity selectivity macrophage secretion were achieved. Furthermore, this validated by blood samples greater...
Immune checkpoint inhibitor therapy has revolutionized the clinical management of a diverse range cancer types, including advanced cutaneous melanoma. While immunotherapy targeting PD-1/PD-L1 system become standard care, overall response rates remain unsatisfactory for most patients and there are no approved small molecule inhibitors system. Flubendazole (FLU) is an anthelmintic that been used to treat worm infections in humans animals decades.Here we tested anti-cancer activity systemically...
Excessive oxidative stress and exercise-induced fatigue reduce physical performance can lead to dysfunction in antioxidant systems within muscular hepatic tissues. Integrating natural substances with exercise may mitigate via anti-oxidant effects. This study aims compare evaluate the effects of supplementation Sundarbans honey vs energy drinks on strength, anxiety physiological profiles, capacity mice undergoing extraneous fatigue. Forty-eight four-week-old Swiss albino were randomly...
A proof-of-concept for the one-step, synthetically challenging cyclic and acyclic perfluoroalkylation of (hetero)arenes driven by valence change a vitamin B12 derivative as cobalt catalyst in presence fluoroalkylating reagents (X(CF2)4X) is presented. The consecutive formation cobalt-carbon bonds generation fluoroalkyl radicals homolysis are key steps reaction to proceed.
Aquatic plants are generally considered as breeding grounds for mosquitoes and other harmful vectors of diseases. However, in recent years, some research has been carried out to test their significance sources antimicrobial lead molecules. The aim this was study the phytochemical composition local aquatic plant species effect against selected bacterial strains. Three different samples were collected from a large water body near Dhaka. Ethanol ethyl acetate extracts species: Eichhornia...
The rural and marginal people of Bangladesh are deprived modern treatment facilities hence greatly depend on medicinal plants.Besides, the higher cost toxicity synthetic drugs drives scientists towards search for natural source medication a number diseases.Cost-effectiveness, easy availability fewer side effects making herbal medicine more popular both among city people.Plants with Cytotoxic clot lysis potential good candidate as novel anti-tumor agents thrombolytic drugs.This study aimed at...
A vitamin B12 derivative with a trifluoromethyl group as an axial ligand, heptamethyl trifluoromethylaquacobyrinate perchlorate, [[(CF3)(H2O)Cob(III)7C1ester]ClO4], is prepared and characterized by elemental analysis, 1H NMR, 19F ESI-MS, UV-vis absorption, cyclic voltammetry. The Co–CF3 complex shows homolysis of the Co(III)–CF3 bond under visible light irradiation, which releases CF3 radical that can be detected trapping experiment. Co–perfluoroalkyl
Background: Kidney transplantation is the preferred treatment for end stage kidney disease (ESKD). Live related donor transplant was started in BIRDEM General Hospital, Bangladesh, on 6th November 2004. The aim of this study to share our last 10 years’ experience live transplant.Methods: A questionnaire formed and data were collected from hospital records. We retrospectively evaluated patients’ clinical laboratory findings.Results: total 111 transplants performed 2004 2014. Male:female...
A metabolic disorder (MD) occurs when the process is disturbed.This carried out by thousands of enzymes participating in numerous inter-dependent pathways.Critical biochemical reactions that involve processing and transportation carbohydrates, proteins lipids are affected diseases.Therefore, it interest to identify common pathways disorders building protein-protein interactions (PPI) for network analysis.The molecular linkages between MD age related diseases (ARD) intriguing.Hence, we...
Background: Diabetes mellitus is a non-communicable disease with increasing prevalence worldwide. The present study was done to identify the modifiable factors that were associated poor glycemic control in Bangladeshi type 2 diabetic patients attending tertiary care hospital.Methods: This cross-sectional conducted Department of Medicine, Sir Salimullah Medical College & Mitford Hospital (SSMC MH), Dhaka from July 2014 June 2015. A total 140 adult diabetes included this study. Of them 70...
Abstract The introduction of combined antiretroviral therapy (cART) has greatly improved the quality life human immunodeficiency virus type 1 (HIV-1)-infected individuals. Nonetheless, ever-present desire to seek out a full remedy for HIV-1 infections makes discovery novel antiviral medication compelling. Owing this, new late-stage inhibitor, Lenacapavir/Sunlenca, an HIV multi-phase suppressor, was clinically authorized in 2022. Besides unveiling cutting-edge antivirals inhibiting proteins...