A5070708120- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Glioma Diagnosis and Treatment
- Blood properties and coagulation
- Hemostasis and retained surgical items
- Alcoholism and Thiamine Deficiency
- Muscle and Compartmental Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Neurological and metabolic disorders
- Vitamin K Research Studies
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Graphene and Nanomaterials Applications
- Advanced Nanomaterials in Catalysis
- Nanopore and Nanochannel Transport Studies
- Vasculitis and related conditions
- Alcohol Consumption and Health Effects
- Electrospun Nanofibers in Biomedical Applications
- Advanced biosensing and bioanalysis techniques
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Case Western Reserve University
2017-2024
Vanderbilt University Medical Center
2023
Case Comprehensive Cancer Center
2017
Effective cancer immunotherapy depends on the robust activation of tumor-specific antigen-presenting cells (APC). Immune agonists encapsulated within nanoparticles (NP) can be delivered to tumor sites generate powerful antitumor immune responses with minimal off-target dissemination. Systemic delivery enables widespread access microvasculature and draining APC-rich perivasculature. We developed an immuno-nanoparticle (immuno-NP) coloaded cyclic diguanylate monophosphate, agonist stimulator...
Metastasis displays a highly heterogeneous cellular population with cancer cells continuously evolving. As result, single-ligand nanoparticle cannot account for the changing expression of targetable biomarkers over time and space. To effectively direct nanoparticles to metastasis, we developed multi-ligand by using four different types ligands on same that target endothelium associated metastatic disease. These vascular targets included αvβ3 integrin, P-selectin, EGFR fibronectin. Using...
After targeting the nanoparticle to brain tumors, widespread drug delivery entire tumor is triggered by a radiofrequency field.
Severe hemorrhage associated with trauma, surgery, and congenital or drug-induced coagulopathies can be life-threatening requires rapid hemostatic management via topical, intracavitary, intravenous routes. For injuries that are not easily accessible externally, approaches needed. The clinical gold standard for this is transfusion of blood products, but due to donor dependence, specialized storage requirements, high risk contamination, short shelf life, product use faces significant...
Abstract Glioblastoma multiforme (GBM) remains highly lethal. This partially stems from the presence of brain tumor initiating cells (BTICs), a plastic cellular subpopulation that is resistant to current therapies. In addition resistance, blood–brain barrier limits penetration most drugs into GBMs. To effectively deliver BTIC‐specific inhibitor tumors, multicomponent nanoparticle, termed Fe@MSN, which contains mesoporous silica shell and an iron oxide core, developed. Fibronectin‐targeting...
Metastasis is responsible for the majority of deaths breast cancer patients. While cytotoxic drugs are available with high potency to kill cells, they not designed specifically seek and navigate in dynamic continuously changing microenvironment metastatic disease. To effectively delivery chemotherapeutic agents metastasis, we a dual-ligand nanoparticle loaded doxorubicin by using two different types ligands targeting EGFR αvβ3 integrin. Metastatic cells change resulting heterogeneity even...
To synthesize multi-component nanochains, we developed a simple ‘one-pot’ synthesis, which exhibited high yield and consistency.
The nonsurgical standard of care for thrombosis is the administration tPA. However, 40% occlusive thrombi resist lysis by These resistant include both arterial and venous types, particularly those linked to ischemic stroke deep vein thrombosis. Clot recalcitrance tPA therapy largely due neutrophil extracellular traps (NETs), protein-rich extrusions DNA that generate in blood clots following recruitment activation. mechanism which NETs contribute resistance remains unexplored. To investigate...
<div>Abstract<p>Effective cancer immunotherapy depends on the robust activation of tumor-specific antigen-presenting cells (APC). Immune agonists encapsulated within nanoparticles (NP) can be delivered to tumor sites generate powerful antitumor immune responses with minimal off-target dissemination. Systemic delivery enables widespread access microvasculature and draining APC-rich perivasculature. We developed an immuno-nanoparticle (immuno-NP) coloaded cyclic diguanylate...
<p>SF1: IFNβ production from macrophages by ELISA analysis; SF2: FMT imaging of mammary tumors ex vivo for spatial localization nanoparticle; SF3: Confocal micrographs DiI-nanoparticle fluorescence in tumor tissue; SF4: Representative images masses 4 days post-treatment; SF5: Primary bioluminescence and change weight 4T1 tumor-bearing mice; SF6: microscopy a representative healthy lung section; SF7: Change B16F10 mice</p>
<p>SF1: IFNβ production from macrophages by ELISA analysis; SF2: FMT imaging of mammary tumors ex vivo for spatial localization nanoparticle; SF3: Confocal micrographs DiI-nanoparticle fluorescence in tumor tissue; SF4: Representative images masses 4 days post-treatment; SF5: Primary bioluminescence and change weight 4T1 tumor-bearing mice; SF6: microscopy a representative healthy lung section; SF7: Change B16F10 mice</p>
2: Six HK structures matched with selected cryoEM maps fit.The N-terminus starts from Q1 and the C-terminus ends S626.C10 C596 are connected by S-S bonds.The changes in position of domains relative to each other visible.His residues highlighted green show their abundance D5.
<div>Abstract<p>Effective cancer immunotherapy depends on the robust activation of tumor-specific antigen-presenting cells (APC). Immune agonists encapsulated within nanoparticles (NP) can be delivered to tumor sites generate powerful antitumor immune responses with minimal off-target dissemination. Systemic delivery enables widespread access microvasculature and draining APC-rich perivasculature. We developed an immuno-nanoparticle (immuno-NP) coloaded cyclic diguanylate...