George Astras

ORCID: 0000-0003-4931-8397
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About
Contact & Profiles
Research Areas
  • Cardiac Ischemia and Reperfusion
  • Microbial Inactivation Methods
  • Anesthesia and Neurotoxicity Research
  • Cardiac and Coronary Surgery Techniques
  • Pancreatic and Hepatic Oncology Research
  • Cancer Genomics and Diagnostics
  • Heparin-Induced Thrombocytopenia and Thrombosis
  • Mechanical Circulatory Support Devices
  • Pituitary Gland Disorders and Treatments
  • Cancer Risks and Factors
  • Cardiac Arrest and Resuscitation
  • Neuroblastoma Research and Treatments
  • Chemotherapy-related skin toxicity
  • Intensive Care Unit Cognitive Disorders
  • Cancer Treatment and Pharmacology
  • Hormonal and reproductive studies
  • Plant tissue culture and regeneration
  • Testicular diseases and treatments
  • Sarcoma Diagnosis and Treatment
  • Nausea and vomiting management
  • HER2/EGFR in Cancer Research
  • Acute Myocardial Infarction Research
  • Gastric Cancer Management and Outcomes
  • Plasma Applications and Diagnostics
  • Music Therapy and Health

American Heart Institute
2015-2022

Onassis Cardiac Surgery Center
2003-2015

Royal Bournemouth Hospital
2009-2011

Bournemouth University
2009

Hygeia Hospital
1995

St Thomas' Hospital
1989

St. Thomas Hospital
1989

Thrombocytopenia and thromboembolism(s) may develop in heparin immune-mediated thrombocytopenia (HIT) patients after reexposure to heparin. At the Onassis Cardiac Surgery Center, 530 out of 17,000 requiring heart surgery over an 11-year period underwent preoperative HIT assessment by ELISA a three-point heparin-induced platelet aggregation assay (HIPAG). The screening identified 110 with HIT-reactive antibodies, which 46 were also thrombocytopenic (true HIT). was performed HIT-positive under...

10.1002/ajh.24017 article EN American Journal of Hematology 2015-03-24

Journal Article Free radicals and cardioplegia: organic anti-oxidants as additives to the St Thomas' Hospital cardioplegic solution Get access D J CHAMBERS, CHAMBERS From Cardiovascular Research, The Rayne Institute, Hospital, London Address for correspondence reprints: Dr Chambers, SE1 7EH, UK. Search other works by this author on: Oxford Academic PubMed Google Scholar G ASTRAS, ASTRAS A TAKAHASHI, TAKAHASHI S MANNING, MANNING M V BRAIMBRIDGE, BRAIMBRIDGE HEARSE Volume 23, Issue 4, April...

10.1093/cvr/23.4.351 article EN Cardiovascular Research 1989-04-01

Innovative tumor profiling methodologies are utilized to elucidate the pharmacogenomic landscape of cells in order support molecularly guided delivery therapeutics. Indeed, improved clinical outcomes achieved oncology practice by providing physicians with expert-guided, standardized, and easily interpretable knowledge, translated from molecular analysis decision-making. However, there is still limited utilization technology especially small private practices. In this work, we analyzed how...

10.3389/fonc.2020.00521 article EN cc-by Frontiers in Oncology 2020-04-28

Locally advanced pancreatic cancer (LAPC) is found in about 40% of patients with cancer. Irreversible electroporation (IRE) a nonthermal ablative technique that provides an alternative LAPC and can be safely combined chemotherapy.From 2015 until October 2019, we performed laparotomic IRE total 40 stage III LAPC. The median age these was 65.2 years (range: 46 to 81 y), the tumor size 3.8 cm 2 5.2 cm). 33 were treated preoperatively FOLFIRINOX or nab-paclitaxel plus gemcitabine case disease...

10.1097/coc.0000000000000826 article EN American Journal of Clinical Oncology 2021-05-12

A 44-year-old man initially presented in August 2008 with iron-deficiency anemia and dysphagia to solids.Endoscopy, endoscopic ultrasound, computed tomography (CT), positron emission tomography-CT, laparoscopy confirmed stage T3N1M0, type 3, moderately differentiated adenocarcinoma of the esophagogastric junction.He was treated perioperative chemotherapy within NCRI (National Cancer Research Institute) ST03 trial, receiving six cycles (three preoperative three postoperative) epirubicin,...

10.1200/jco.2011.35.8317 article EN Journal of Clinical Oncology 2011-06-07

Purpose of study: To evaluate the effectiveness new mechanical bi-leaflet valve ATS. Methods used: Replacement cardiac valve(s) with ATS prosthesis was performed in 280 patients (133 female) by our Department. Of them, 103 had aortic replacement (AVR), 141 mitral (MVR), and 36 both (DVR). All severe pathology confirmed echocardiographic evaluation catheterization preoperatively. Patients’ age ranged from 22 to 80 years; mean 60.2±10.11 years. Postoperative oral anticoagulation prescribed for...

10.1097/00002480-200603000-00174 article EN ASAIO Journal 2006-03-01

e15723 Background: LAPC represents 40% of PC pts. IRE is a non-thermal ablative technique that can be used in inoperable pts and safely combined with C. Methods: From 2015 to 2018 laparotomic was performed total 34 The median age 64.7yrs (range, 46-81yrs) 15 (44%) were males. tumor size 3.9cm 2-5.2cm) the majority tumors located at pancreatic head (26 pts, 76%), followed by body (6 18%) tail pancreas (2 6%). Induction C applied 27 out case disease control done, while 7 done without prior In...

10.1200/jco.2019.37.15_suppl.e15723 article EN Journal of Clinical Oncology 2019-05-20
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