A5078720229- Plant Pathogens and Fungal Diseases
- Plant and fungal interactions
- Genomics and Chromatin Dynamics
- Histone Deacetylase Inhibitors Research
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Immune Response and Inflammation
- Marine Sponges and Natural Products
- Ion channel regulation and function
- Cancer-related gene regulation
- Calcium signaling and nucleotide metabolism
- Angiogenesis and VEGF in Cancer
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Forest Insect Ecology and Management
- Receptor Mechanisms and Signaling
- Mycorrhizal Fungi and Plant Interactions
- Complement system in diseases
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Nanoplatforms for cancer theranostics
- Phytochemical compounds biological activities
- Ion Channels and Receptors
Transnational Press London
2016-2017
Cancer Care Ontario
2017
Lawson Health Research Institute
2016
Carleton University
2014-2015
Kyushu Institute of Technology
2010-2014
Western University
2014
Kagoshima University
2011
Phytochemical investigation and bioactivity evaluation of terpenoids from the Croton species were conducted. The chemical composition C. sylvaticus was explored using phytochemical screening techniques dereplication 13C NMR data MixONat software (v. 1.0.1). Natural products with diverse structural features identified in dichloromethane extract trunk bark. These include monoterpenoids, sesquiterpenoids, diterpenoids, triterpenoids, along other minor metabolites, such as steroids, saponins,...
Phialocephala scopiformis Kowalski & Kehr is a foliar fungal endophyte of white spruce (Picea glauca (Moench) Voss) that produces the anti-insect compound rugulosin and other compounds in lower amounts. Seedlings inoculated with this toxigenic endophytes have increased tolerance to budworm Choristoneura fumiferana (Clemens, 1865). The presence diet needles infected by P. reduces growth rate insect. One 300 trees as seedling 2001 was chosen investigate distribution its principal toxin...
Viral nanoparticles decorated with peptides targeting EGFL7 label tumor-associated blood vessels high specificity as assessed by intravital imaging.
Seven new secondary metabolites, four isochromans (1–4) and three α-pyrones (5–7), were isolated from Penicillium corylophilum DAOM 242293 collected a damp building in Halifax, Canada. Their structures elucidated by HRESIMS, 1D 2D NMR, chemical derivatization, ORD, UV, comparison to the literature. Related have previously been reported other species; however, our knowledge this is first report of P. corylophilum. Compounds 1–4 demonstrated antifungal activity against Saccharomyces cerevisiae...
Indoor exposure to the spores and mycelial fragments of fungi that grow on damp building materials can result in increased non-atopic asthma upper respiratory disease. The mechanism appears involve low doses fungal metabolites. Penicillium corylophilum is surprisingly common buildings USA, Canada western Europe. We examined isolates P. geographically distributed across first comprehensive study secondary metabolites this fungus. sesquiterpene phomenone, meroterpenoids citreohybridonol...
Skp derived from Escherichia coli attracts leukocytes as a pure chemotactic ligand of the C5a receptor. We identified submolecular region that binds and activates receptor to be -Gln103-Asp104-Arg105- using synthetic peptide fragments site-directed mutants Skp. As amino acid residue equivalent Gln103 is Leu72, we prepared Gln103Leu-Skp mutant recombinant protein. With this mutation, gained secretagogue functions including induction respiratory burst granule release reactions leukotriene...
Abstract As a tumor grows beyond 1mm, it recruits new blood vessels through the process of angiogenesis. The selective inhibition vascular endothelial growth factor (VEGF) pathway increases efficacy chemotherapy and has beneficial effects on multiple advanced cancers, but response is often limited disease eventually progresses. This highlights necessity to develop novel therapeutics that target alternate angiogenic signaling pathways. epidermal factor-like domain 7 (EGFL7) secreted protein...