A5042426887- Pulmonary Hypertension Research and Treatments
- Circular RNAs in diseases
- Cardiomyopathy and Myosin Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cardiovascular Function and Risk Factors
- Reproductive System and Pregnancy
- Mitochondrial Function and Pathology
- Cardiovascular Issues in Pregnancy
- Cancer-related molecular mechanisms research
- ATP Synthase and ATPases Research
- IL-33, ST2, and ILC Pathways
Queen's University
2021-2024
Drp1 (dynamin-related protein 1), a large GTPase, mediates the increased mitochondrial fission, which contributes to hyperproliferation of pulmonary artery smooth muscle cells in arterial hypertension (PAH). We developed potent GTPase inhibitor, Drpitor1a, but its specificity, pharmacokinetics, and efficacy PAH are unknown.
Natural killer (NK) cell impairment is a feature of pulmonary arterial hypertension (PAH) and contributes to vascular remodeling in animal models disease. Although mutations
Abstract Germline loss-of-function BMPR2 mutations are the leading genetic cause of pulmonary arterial hypertension (PAH) and strongly linked to aberrant endothelial proliferation impaired translational stress responses. While these effects generally attributed a loss type-II bone morphogenetic protein receptor (BMPR-II), we used circular RNA profiling identify circ5078 as new functional derived from exon 12 gene. linear mRNA exert opposing on granule formation, driving responses in PAH...
Rationale -Pulmonary arterial hypertension (PAH) is deadly disease characterized by vascular remodeling and endothelial dysfunction.PAH linked to heterozygous loss of function mutations in BMPR2, which encodes the bone morphogenetic protein (BMP) type II receptor.While dysfunction a key player PAH development, underlying mechanisms driving this remain unclear.There has been emerging interest role alternative RNA transcripts not captured traditional studies including circular RNAs...