A5052468038- Marine Sponges and Natural Products
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Berberine and alkaloids research
- Natural product bioactivities and synthesis
- Silymarin and Mushroom Poisoning
- Biological Activity of Diterpenoids and Biflavonoids
- Skin Protection and Aging
- PI3K/AKT/mTOR signaling in cancer
- Advanced Proteomics Techniques and Applications
- Plant biochemistry and biosynthesis
- Chemical Reactions and Isotopes
- Polyamine Metabolism and Applications
- Echinoderm biology and ecology
- Cancer, Hypoxia, and Metabolism
- Synthesis and Biological Activity
- Synthesis and bioactivity of alkaloids
- Edible Oils Quality and Analysis
- Marine Biology and Environmental Chemistry
- Tannin, Tannase and Anticancer Activities
- Vitamin C and Antioxidants Research
- Acute Lymphoblastic Leukemia research
- Glycosylation and Glycoproteins Research
- Phytochemistry and biological activities of Ficus species
- Hibiscus Plant Research Studies
Universitat de Miguel Hernández d'Elx
2012-2024
Mattel Children's Hospital
2024
Colorectal cancer is the third most common diagnosed globally. Although substantial advances have been obtained both in treatment and survival rates, there still a need for new therapeutical approaches. Natural compounds are realistic source of bioactive with anticancer activity. Among them, rosemary polyphenols shown vast antiproliferative capacity against colon cells vitro animal models. We investigated antitumor activity extract (RE) by using supercritical fluid extraction through its to...
Ultraviolet (UV) radiation, especially types A (UVA) and B (UVB), is one of the main causes skin disorders, including photoaging cancer. Ultraviolent radiation oxidative stress, inflammation, p53 induction, DNA damage, mutagenesis, oxidation various molecules such as lipids proteins. In recent decades, use polyphenols with an antioxidant anti-inflammatory capacity has increased. However, some these compounds are poorly soluble, information regarding their absorption bioavailability scarce....
An ever-growing number of preclinical studies have investigated the tumoricidal activity milk thistle flavonolignan silibinin. The clinical value silibinin as a bona fide anti-cancer therapy, however, remains uncertain with respect to its bioavailability and blood–brain barrier (BBB) permeability. To shed some light on absorption silibinin, we utilized Caco-2 cell monolayer model human intestinal evaluate permeation properties three different formulations silibinin: silibinin-meglumine,...
Mammalian target of rapamycin (mTOR) is a PI3K-related serine/threonine protein kinase that functions as master regulator cellular growth and metabolism, in response to nutrient hormonal stimuli. mTOR two distinct complexes-mTORC1 sensitive rapamycin, while, mTORC2 insensitive this drug. Deregulation mTOR's enzymatic activity has roles cancer, obesity, aging. Rapamycin its chemical derivatives are the only drugs inhibit hyperactivity mTOR, but numerous side effects have been described due...
Marine compounds are a potential source of new anticancer drugs. In this study, the antiproliferative effects 20 invertebrate marine extracts on three colon cancer cell models (HGUE-C-1, HT-29, and SW-480) were evaluated. Extracts from two nudibranchs (Phyllidia varicosa, NA Dolabella auricularia, NB), holothurian (Pseudocol ochirus violaceus, PS), soft coral (Carotalcyon sp., CR) selected due to their potent cytotoxic capacities. The four exhibited strong induced cycle arrest at G2/M...
The present study shows the putative antiproliferative mechanism of action previously analytically characterized nudibranch extract ( Dolabella auricularia, NB) and its different effects in colon cancer cells vs. nontumor cells. NB increased accumulation reactive oxygen species (ROS) endoplasmic reticulum (ER) stress via stimulation unfolded protein response. Stress scavengers, N-acetylcysteine (NAC) 4-phenylbutyric acid (4-PBA), decreased induced by NB. results showed that ER through...
Abstract L-asparaginase (Calaspargase-pegol, PEG) is currently an important component of acute lymphoblastic leukemia (ALL) treatment in children, adolescents, and young adults. Despite its high efficacy, toxicities including hepatotoxicity limit use. Asparaginase-associated often associated with obesity fatty liver, highlighting lipid metabolism as a potential contributor to liver. Therefore, we performed lipidomic analyses plasma liver from control obese mice treated one dose PEG,...
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Introduction Marine invertebrate organisms have received great attention from the scientific community due to its richness in new bioactive compounds with potential anti-proliferative and anticancer activities. In present study, cytotoxic efficacy of four marine invertebrate-extracts against human adenocarcinoma colon cancer cells was investigated. Material methods HT29, SW480 HGUE-C-1 cell lines were cultured exposed 4 extracts at different concentrations for 24 hour. The properties...
Introduction Rosmarinus officinalis L., commonly called rosemary, is one of the most widely used and commercialised plant for obtaining botanical extracts which are not only as a culinary herb flavouring but also an antioxidant ingredient in processed foods cosmetics. This has been traditionally herbal medicine large variety disorders. Its beneficial effects have attributed to high content bioactive compounds, such phenolic diterpenes, flavonoids other compounds. Material methods In this...
Introduction Rosmarinus officinalis L., commonly called rosemary, is a shrub from Labiatae (Lamiaceae) family that mostly distributed throughout the Mediterranean area. Its beneficial effects have been attributed to high content in bioactive compounds, such as phenolic diterpenes, flavonoids and other compounds. Rosemary extracts (RE) their main compounds demonstrated various health-beneficial activities, including antioxidant, hepatoprotective, antimicrobial, anti-inflammatory, anti-cancer...
Introduction The phosphoinositide 3-kinase (PI3Ks)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signalling pathway is essential for tumorigenesis and metastasis in many types human tumours some tumour cells owe their hyperproliferative capacity to the overactivation this pathway, response mutations that abolish repressing genes. Therefore, inhibition mTOR subsequent activation autophagy has been postulated as a therapeutic certain tumours. control route governed by can...
Introduction Novel marine compounds supposed an unexplored source of new drugs and expand the possibilities finding active molecules in all different signatures cancer, such as proliferation, invasion metastases. Here we report capacity four invertebrate extracts that inhibit migration colon cancer cell model. Material methods HCT116 line was cultured exposed to (CR from a red coral, PS holothurian NA NB nudibranchs) at concentrations for 24 hour IC50 calculated by MTT assay estimate...