A5074263991- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Phytochemicals and Antioxidant Activities
- Sexual Differentiation and Disorders
- PARP inhibition in cancer therapy
- Hormonal and reproductive studies
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Essential Oils and Antimicrobial Activity
- Skin Protection and Aging
Institut Català d'Oncologia
2018-2025
Institut d'Investigació Biomédica de Bellvitge
2025
Ultraviolet (UV) radiation, especially types A (UVA) and B (UVB), is one of the main causes skin disorders, including photoaging cancer. Ultraviolent radiation oxidative stress, inflammation, p53 induction, DNA damage, mutagenesis, oxidation various molecules such as lipids proteins. In recent decades, use polyphenols with an antioxidant anti-inflammatory capacity has increased. However, some these compounds are poorly soluble, information regarding their absorption bioavailability scarce....
Abstract Alternative end-joining (alt-EJ) is an error-prone DNA repair pathway that cancer cells deficient in homologous recombination rely on, making them vulnerable to synthetic lethality via inhibition of poly(ADP-ribose) polymerase (PARP). Targeting alt-EJ effector theta (POLθ), which synergizes with PARP inhibitors and can overcome resistance, significant preclinical clinical interest. However, the transcriptional regulation its interactions processes driving progression remain poorly...
Mutations of the androgen receptor (AR) associated with prostate cancer and insensitivity syndrome may profoundly influence its structure, protein interaction network, binding to chromatin, resulting in altered transcription signatures drug responses. Current structural information fails explain effect pathological mutations on AR structure-function relationship. Here, we have thoroughly studied effects selected that span complete dimer interface ligand-binding domain (AR-LBD) using x-ray...