A5027797639- Analytical chemistry methods development
- Heavy Metal Exposure and Toxicity
- Electrochemical Analysis and Applications
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Estrogen and related hormone effects
- Pharmacogenetics and Drug Metabolism
- NF-κB Signaling Pathways
- Environmental Toxicology and Ecotoxicology
- Inorganic and Organometallic Chemistry
- Trace Elements in Health
- Plant Toxicity and Pharmacological Properties
- Immune Response and Inflammation
- Amphibian and Reptile Biology
- Heavy metals in environment
- Antioxidant Activity and Oxidative Stress
- Analytical Chemistry and Sensors
- Water Quality and Pollution Assessment
- Water Resource Management and Quality
- Growth Hormone and Insulin-like Growth Factors
- Soil Science and Environmental Management
- Public Health and Environmental Issues
- Neurogenetic and Muscular Disorders Research
- Steroid Chemistry and Biochemistry
- Marine Biology and Ecology Research
Hospital de Sant Pau
1998-2022
National University of San Luis
1987-2012
Consejo Nacional de Investigaciones Científicas y Técnicas
2007-2012
Institut d'Investigacions Biomèdiques de Barcelona
2012
Universidad de Cádiz
2009
Universitat Autònoma de Barcelona
2004-2007
University of the Andes
2005
Universidad Complutense de Madrid
1996
Czech Academy of Sciences, Institute of Analytical Chemistry
1995
Apolipoprotein A-II (apoA-II), the second major high-density lipoprotein (HDL) apolipoprotein, has been linked to familial combined hyperlipidemia. Human apoA-II transgenic mice constitute an animal model for this proatherogenic disease. We studied ability of human HDL protect against oxidative modification apoB-containing lipoproteins. When challenged with atherogenic diet, antigens related low-density (LDL) oxidation were markedly increased in aorta 11.1 (high expressor). from control and...
Inflammation and immune-mediated processes are pivotal to the pathogenic progression of age-related macular degeneration (AMD). Although plasma levels C-reactive protein (CRP) have been shown be associated with an increased risk for AMD, pathophysiological importance prototypical acute-phase reactant in etiology disease is unknown, data regarding exact role CRP ocular inflammation limited. In this study, we provide mechanistic insight into how contributes development AMD. particular, show...
Prostaglandin (PG)E2 is relevant in tumor biology, and interactions between stroma cells dramatically influence progression. We tested the hypothesis that cross-talk head neck squamous cell carcinoma (HNSCC) fibroblasts could substantially enhance PGE2 biosynthesis. observed an enhanced production of cocultures HNSCC lines fibroblasts, which was consistent with upregulation COX-2 microsomal PGE-synthase-1 (mPGES-1) fibroblasts. In cultured endothelial cells, medium from treated...
Mutations of the androgen receptor (AR) associated with prostate cancer and insensitivity syndrome may profoundly influence its structure, protein interaction network, binding to chromatin, resulting in altered transcription signatures drug responses. Current structural information fails explain effect pathological mutations on AR structure-function relationship. Here, we have thoroughly studied effects selected that span complete dimer interface ligand-binding domain (AR-LBD) using x-ray...
Abstract The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that controls metabolic and homeostatic processes essential for life. Although numerous crystal structures of the GR ligand-binding domain (GR-LBD) have been reported, functional oligomeric state full-length receptor, which its transcriptional activity, remains disputed. Here we present five new agonist-bound GR-LBD, along with thorough analysis previous structural work. We identify four distinct...
Embalse La Florida is an artificial lake located in midwestern Argentina's San Luis province. It provides drinking water to ∼70% of the province's human population and ∼20% province irrigated with from reservoir. The presence heavy metals Florida's has previously been reported. Nevertheless, no information about levels these contaminants birds available for this region. aim study, therefore, (1) establish baseline data on lead (Pb) cadmium (Cd) Florida, (2) assess metal accumulation patterns...
There is evidence that polymorphonuclear neutrophils (PMNs) can exert severe antineoplastic effects. Cross-talk between tumour cells and endothelial (ECs) necessary for the accumulation of PMN around a tumour. This work reports ability two PMN-sensitive, human, permanent cell lines-colorectal adenocarcinoma (HT-29) pharyngeal squamous-cell carcinoma (FaDu) cells-to act as inflammatory foci. PMNs were cytotoxic to both lines, adhesion being important in this effect. The released appreciable...