A5084179238- Nutrition and Health in Aging
- Frailty in Older Adults
- Body Composition Measurement Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Cerebral Palsy and Movement Disorders
- Muscle Physiology and Disorders
- Obesity, Physical Activity, Diet
- Obesity and Health Practices
- Physical Activity and Health
- Birth, Development, and Health
- Infant Nutrition and Health
- Hip and Femur Fractures
- Health and Well-being Studies
- Clinical Nutrition and Gastroenterology
- Geriatric Care and Nursing Homes
- Muscle metabolism and nutrition
- Health disparities and outcomes
- Muscle activation and electromyography studies
- Meta-analysis and systematic reviews
- Telomeres, Telomerase, and Senescence
- Cardiac, Anesthesia and Surgical Outcomes
- Health, Environment, Cognitive Aging
- Autoimmune and Inflammatory Disorders Research
- HIV-related health complications and treatments
Newcastle University
2016-2024
NIHR Newcastle Biomedical Research Centre
2018-2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2018-2024
Cumbria Northumberland Tyne and Wear NHS Foundation Trust
2023-2024
University of Newcastle Australia
2016-2022
National Institute for Health Research
2021
University of Southampton
2012-2019
Newcastle Hospitals - Campus for Ageing and Vitality
2016-2019
Newcastle upon Tyne Hospital
2019
MRC Lifecourse Epidemiology Unit
2012-2016
Sarcopenia is a generalised skeletal muscle disorder characterised by reduced strength and mass associated with range of negative health outcomes. Currently, resistance exercise (RE) recommended as the first-line treatment for counteracting deleterious consequences sarcopenia in older adults. However, whilst there considerable evidence demonstrating that RE an effective intervention improving function healthy adults, much less known about its benefits people living sarcopenia. Furthermore,...
Abstract Introduction Recognition that an older person has sarcopenia is important because this condition linked to a range of adverse outcomes. Sarcopenia becomes increasingly common with age, and yet there are few data concerning its descriptive epidemiology in the very old (aged 85 years above). Our aims were describe risk factors for estimate prevalence incidence British sample old. Methods We used from two waves (2006/07 2009/10) Newcastle 85+ Study, cohort born 1921 registered...
Sarcopenia, the loss of muscle strength and mass, predicts adverse outcomes becomes common with age. There is recognition that sarcopenia may occur at younger ages in those long-term conditions (LTCs) as well multimorbidity (the presence two or more LTCs), but their relationships have been little explored. Our aims were to describe prevalence UK Biobank, a large sample men women aged 40-70 years, explore different categories LTCs multimorbidity.We used data from 499 046 participants baseline...
Introduction: observational studies do not always find positive associations between physical activity and muscle strength despite intervention consistently showing that exercise improves in older adults. In previous analyses of the MRC National Survey Health Development (NSHD), 1946 British birth cohort, there was no evidence an association leisure time (LTPA) across adulthood grip at age 53. This study tested hypothesis cumulative benefits LTPA mid-life on will have emerged by 60–64....
<h3>ABSTRACT</h3> Sarcopenia and frailty are important conditions that become increasingly prevalent with age. is the loss of muscle mass function, can be defined as multi-system impairment associated increased vulnerability to stressors. There overlap between two conditions, especially in terms physical aspects phenotype: low grip strength, gait speed mass. These measures have been a wide range ageing outcomes assessed clinical setting. In intervention, there evidence for benefit resistance...
Abstract The past three decades have seen a steady increase in the availability of routinely collected health and social care data processing power to analyse it. These developments represent major opportunity for ageing research, especially with integration different datasets across traditional boundaries care, prognostic research novel evaluations interventions representative populations older people. However, there are considerable challenges using routine at level coding, analysis...
Introduction: Epidemiological studies have shown that weaker grip strength in later life is associated with disability, morbidity and mortality.Grip a key component of the sarcopenia frailty phenotypes yet it unclear how individual measurements should be interpreted.Using data from general population Great Britain, our objective was to produce cross-sectional centile values for across course.Methods: We combined 60,803 observations 49,964 participants (26,687 female) 12 Britain.We produced...
weak hand grip strength in later life is a risk factor for disability, morbidity and mortality central to definitions of sarcopenia frailty. It unclear whether rate change adds level as poor ageing outcomes. study participants were 292 community-dwelling men women whose was measured during the 1994/5 (average age 67) 2003/5 76) phases Hertfordshire Ageing Study, UK. Individual estimated using residual method. Mortality followed-up 2011 (42 21 died). average strengths 38.4 kg (standard...
Lower grip strength on admission to hospital is known be associated with longer stay, but the link between customary and risk of future less clear.To compare subsequent among community-dwelling older people in a U.K. setting.Cohort study linked administrative data.Hertfordshire, U.K.A total 2,997 men women aged 59-73 years at baseline.The Hertfordshire Cohort Study (HCS) participants completed baseline assessment 1998 2004, during which was measured. Hospital Episode Statistics mortality...
Regular physical activity (PA) is associated with reduced risk of the development and progression musculoskeletal, metabolic vascular disease. However, PA declines age this can contribute to multiple adverse outcomes. The aims study were describe relationship between accelerometer-determined PA, body composition sarcopenia (the loss muscle mass function age). Seven-day was measured using GENEactiv accelerometer among 32 men 99 women aged 74-84 years who participated in Hertfordshire...
Abstract Purpose The European Working Group on Sarcopenia in Older People 2 (EWGSOP2) consensus definition introduced the concept of probable sarcopenia as a basis which to begin treatment. Our aims were describe prevalence older adults and investigate utility (1) SARC-F tool (2) clinical risk factors for identification those likely have sarcopenia. Methods We used data from 1946 British birth cohort at age 69, with 1686 participants included analyses. EWGSOP2 cut points weak grip strength...
the application of process Comprehensive Geriatric Assessment (CGA), based on extrapolation from existing evidence base for CGA 12 .In addition, exercise training may be able to prevent or improve frailty 13,14 .A key challenge in improving outcomes older people with sarcopenia is ensure that research findings are translated into clinical practice.Conversely, programmes need designed and delivered ways fit Abstract Objectives: Despite a rising profile, there limited information about how...
Few studies have explored the activity levels of hospitalised older people and intra-daily patterns in this group not been described. To describe quantity daily pattern physical among using two accelerometers: ankle-worn StepWatch Activity Monitor (SAM), wrist-worn GENEActiv. This cross-sectional observational study was conducted on acute medical wards for one UK hospital. Inclusion criteria: participants aged ≥ 70 years, able to mobilise prior admission. Participants wore both devices up...
to investigate the associations between initial level and rate of change in grip strength (GS) all-cause mortality very old adults (≥85 years) over a 9.6-year follow-up. prospective data from 845 participants Newcastle 85+ Study were analysed for survival relation GS (kg, baseline 5-year mean change) using Cox proportional hazards models. during follow-up, 636 (75.3%) died. Higher was associated with decreased risk all [hazard ratio (HR) = 0.95, 95% confidence interval (CI): 0.93–0.98, P <...