A5069154786- Viral Infections and Vectors
- Chemokine receptors and signaling
- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- Mosquito-borne diseases and control
- Apelin-related biomedical research
- Syphilis Diagnosis and Treatment
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Cancer Treatment and Pharmacology
- Microbial Metabolites in Food Biotechnology
- Biofuel production and bioconversion
- Peptidase Inhibition and Analysis
- Diagnosis and treatment of tuberculosis
- Gestational Diabetes Research and Management
- Circular RNAs in diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vascular Anomalies and Treatments
- Tracheal and airway disorders
- Medical Coding and Health Information
- Vascular Malformations and Hemangiomas
- Malaria Research and Control
- Inflammasome and immune disorders
- Medical Imaging and Pathology Studies
- Colorectal Cancer Treatments and Studies
Ochanomizu University
2021-2023
Miyazaki Prefectural Hospital
2022
Funabashi Municipal Medical Center
2002-2011
Mie University
2002
The University of Tokyo
2000-2001
Chiba University
2000-2001
Abstract We have investigated the involvement of chemokine receptor CCR1-positive cells in bleomycin-induced lung injury, a model pulmonary fibrosis. After bleomycin challenge C57BL/6J mice, expression CCR1 mRNA increased and peaked at day 7, which paralleled to its ligands, macrophage-inflammatory protein-1α RANTES. Immunohistochemical study showed that accumulated interstitial inflammatory site. Furthermore, treatment anti-CCR1 Ab significantly reduced accumulation collagen deposition,...
We report the isolation of dengue virus type 2 from a patient returning to Japan Nepal in October, 2004. This is first isolate Nepal. According nucleotide homology, was closest India.
Chemokine-chemokine receptor interaction plays an essential role in leukocyte/dendritic cell (DC) trafficking inflammation and immune responses. We investigated the pathophysiological roles of secondary lymphoid tissue chemokine (SLC; CCL21) macrophage inflammatory protein-2 (MIP-2) development acute pulmonary induced by intratracheal injection Propionibacterium acnes mice. Immunohistochemical studies revealed that SLC was constitutively expressed peribronchial areas perivascular lymphatics...
Abstract Aims To evaluate the coronavirus disease 2019 pandemic's impact on pregnancy outcomes in a Japanese rural area. Methods This retrospective study focused periods between March 1, 2020, and February 28, 2021 (during pandemic), January 2017, December 31, 2019. Singleton pregnancies delivered at or after 22 gestational weeks were included. Preterm delivery, low‐birth‐weight, small‐for‐gestational‐age infant rates during pandemic compared to those preceding 3 years. Results In control...
Two strains of acid-tolerant and starch-degradable yeast were isolated from rivers flowing in Kusatsu Manza, considering an effective reuse great mass starch-based biodegradable plastic. The could grow acid media pH 1.8 identified as Candida fluviatinis intermedia. yeasts assimilate many carbon sources ferment glucose sucrose to alcohol.
We report three dengue fever cases, infected during a group tour to the Philippines. A 58-year old male experienced sudden onset of high 5 days after returning Japan, followed by rash and thrombocytopenia. The other 2 cases similar symptoms. Clinically suspected from travel history, incubation time state epidemic in Philippines, virus infection was confirmed laboratory tests. incidence geographical distribution have greatly increased recent years. There been reports Japanese travelers who...
Pancreatic islet β-cells weaken under oxidative stress. In this study, human pancreatic islet-derived 1.1B4 cells were exposed to H2O2 and analysed using a microarray, which revealed that heme oxygenase 1 (HMOX1), glutamate-cysteine ligase, early growth response 1, nuclear receptor subfamily 4 group A member 3 (NR4A3) jun B proto-oncogene upregulated, whereas superoxide dismutase catalase not. Expression of NR4A3 rapidly increased after addition, the treated with siRNA targeting became...
ABSTRACT The mechanism of antioxidant defense system is still controversial. As islet ß-cell weak in oxidative condition, that causes diabetes mellitus, therefore, human pancreatic derived 1.1B4 cell was analyzed. Cells were exposed to H 2 O and comprehensive gene expression analyzed by Agilent microarray. HMOX1 NR4A3 , member orphan receptor, up-regulated. Therefore, knocked down with siRNA, then microarray, found the cells stress. strongly inhibited siRNA responsible sequence aaggtca near...