A5072076046- Lipoproteins and Cardiovascular Health
- Birth, Development, and Health
- dental development and anomalies
- Cleft Lip and Palate Research
- Health disparities and outcomes
- Child and Adolescent Health
- Parkinson's Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Obesity, Physical Activity, Diet
- Pharmaceutical Economics and Policy
- Congenital heart defects research
- Psychology of Moral and Emotional Judgment
- Early Childhood Education and Development
- Experimental Behavioral Economics Studies
- Neurological disorders and treatments
- Decision-Making and Behavioral Economics
- Cancer, Lipids, and Metabolism
- Ovarian cancer diagnosis and treatment
- Gestational Diabetes Research and Management
- Autoimmune Neurological Disorders and Treatments
- Optimism, Hope, and Well-being
- Adipose Tissue and Metabolism
- Infant Development and Preterm Care
- Melanoma and MAPK Pathways
- Parkinson's Disease and Spinal Disorders
UCB Pharma (Belgium)
2022-2024
Amgen (United Kingdom)
2014-2023
University College Birmingham
2023
Amgen (United States)
2019-2020
University College London
2005-2016
Imperial College London
2009-2015
University of London
2015
Medical Research Council
2010-2014
Public Health England
2014
University of Oxford
2013
Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these influence height growth during childhood. We derived peak velocity in infancy (PHV1) and puberty (PHV2) timing pubertal spurt from parametric curves fitted to longitudinal data test their known variants. The study consisted N = 3,538 singletons the prospective Northern Finland Birth Cohort 1966 genotype frequent measurements (on average 20 per...
:
The authors examined associations between postnatal growth velocity through age 2 years and metabolic outcomes at 31 in a population-based birth-cohort study of 3,778 Finns (1966–1998). Approximately 8 height measurements 9 weight were obtained from birth to years. Peak (PHV) peak (PWV) infancy derived parametric curves fitted longitudinal data. Body mass index (BMI), waist circumference (WC), high density lipoprotein (HDL) cholesterol, triglycerides, glucose, systolic diastolic blood...
Abstract Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of in toddlers European descent from up to four EArly Genetics Lifecourse Epidemiology consortium, analysing an (15–18 months, ‘one-word stage’, N Total =8,889) later (24–30 ‘two-word =10,819) phase language acquisition. For phase, one single-nucleotide polymorphism...
Tooth development is a highly heritable process which relates to other growth and developmental processes, interacts with the of entire craniofacial complex. Abnormalities tooth are common, agenesis being most common anomaly in humans. We performed genome-wide association study time first eruption number teeth at one year 4,564 individuals from 1966 Northern Finland Birth Cohort (NFBC1966) 1,518 Avon Longitudinal Study Parents Children (ALSPAC). identified 5 loci P<5×10−8, suggestive...
To evaluate the impact of maternal BMI on intrapartum interventions and adverse outcomes that may influence choice planned birth setting in healthy women without additional risk factors.Prospective cohort study.Stratified random sample English obstetric units.17,230 medical or factors other than obesity.Multivariable log Poisson regression was used to effect perinatal adjusted for characteristics.Maternal intervention requiring care (composite of: augmentation, instrumental delivery,...
Background While recent literature has highlighted the importance of early childhood development for later life outcomes, comparatively little is known regarding relative physical and cognitive in predicting educational attainment cross-culturally. Methods We used prospective data from three birth cohorts: Northern Finland Birth Cohort 1986 (NFBC1986), 1970 British Study (BCS1970), Cebu Longitudinal Health Nutrition Survey 1983 (CLHNS) to assess association height-for-age z-score (HAZ)...
Parenting style is associated with offspring health, but whether it mortality at older ages remains unknown.We examined childhood experiences of suboptimal parenting are increased risk death ages.Longitudinal cohort study 1964 community-dwelling adults aged 65-79 years.The association between and was inverse graded. Participants in the poorest score quartile had (hazard ratio (HR) = 1.72, 95% CI 1.20-2.48) compared those optimal after adjustment for age gender. Full covariates partially...
Familial hypercholesterolemia (FH) is common, but underdiagnosed, and few systematic early screening programs exist. To assess health outcomes among those with a recorded diagnosis of FH potential cases no diagnosis. Retrospective cohort study using the UK Clinical Practice Research Datalink. Records adults were classified as diagnosed (FHCoded), or via accepted algorithms LDL-C clinical characteristics (FHPotential) unlikely (FHUnlikely) DLCN EUROASPIRE criteria (but record FH). Outcomes...
Abstract Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative brain disease with rapid progression and currently limited treatment options. A comprehensive understanding of progression, management, healthcare resource utilization limited, further research challenging due to the small population patients. To address these challenges in conducting PSP research, individuals were recruited using multichannel approach tailored specifically community. We performed...
We extend the experimental literature on Bayesian herding using evidence from a financial decision-making experiment. identify significant propensities to herd increasing with degree of herd-consensus. test various models capture differential impacts Bayesian-style thinking versus behavioural factors. find statistically associations between and individual characteristics such as age personality traits. Overall, our is consistent explanations outcome social Suggestions for further research...
Progressive supranuclear palsy (PSP) is a rare, relentlessly progressive, ultimately fatal neurodegenerative brain disease. The objective of this study was to assess the burden PSP on patients, caregivers, and healthcare systems by phenotype. Data were drawn from Adelphi Disease Specific Programme™, cross-sectional neurologists people living with in United States America, France, Germany, Italy, Spain, Kingdom. All reported phenotype included. for 242 patients (mean age: 70.2 years, 58%...
Tooth development is a highly heritable process which relates to other growth and developmental processes, interacts with the of entire craniofacial complex.Abnormalities tooth are common, agenesis being most common anomaly in humans.We performed genome-wide association study time first eruption number teeth at one year 4,564 individuals from 1966 Northern Finland Birth Cohort (NFBC1966) 1,518 Avon Longitudinal Study Parents Children (ALSPAC).We identified 5 loci P,5610 28 , suggestive...
Background and aims Untreated Familial Hypercholesterolemia (FH) leads to premature morbidity mortality. In France, its epidemiology management are understudied in ambulatory care. We described the clinical profile, pharmacological management, outcomes a French sample of FH patients. Methods This was retrospective longitudinal study on patients from The Health Improvement Network (THIN ® ) database between October 2016-June 2019. Patients ≥18 years, with probable/definite based Dutch Lipid...
Methods: A cross-sectional study was carried out in France with patients over 18 years, diagnosed advanced (stage IIIB–IV) or recurrent EOC between 2009 and 2012. total of 23 physicians (oncologists gynecologists) participated, contributing 127 patients. Data were abstracted by participating into a case report form. Results: Of the included, 92 (72.4%) had 35 (27.6%) EOC. 73 comorbidities reported 44 (34.6%). Vascular (10.2%), metabolic (7.1%), respiratory (5.5%), psychiatric disorders...