A5060362389- Cystic Fibrosis Research Advances
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Infections and bacterial resistance
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Inhalation and Respiratory Drug Delivery
- Biosensors and Analytical Detection
- Tracheal and airway disorders
- Bacterial Identification and Susceptibility Testing
- Mycobacterium research and diagnosis
- Legionella and Acanthamoeba research
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Gut microbiota and health
- Organoboron and organosilicon chemistry
- Plant Pathogenic Bacteria Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Bacterial Genetics and Biotechnology
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer therapeutics and mechanisms
- Actinomycetales infections and treatment
- Catalytic Cross-Coupling Reactions
- Infectious Diseases and Mycology
- Antibiotics Pharmacokinetics and Efficacy
Hospices Civils de Lyon
2013-2024
Université Claude Bernard Lyon 1
2012-2023
Centre National de la Recherche Scientifique
2012-2023
Inserm
2006-2023
Centre International de Recherche en Infectiologie
2020-2023
École Normale Supérieure de Lyon
2022-2023
VetAgro Sup
2012-2021
Hôpital de la Croix-Rousse
2019-2020
Institut Mérieux (France)
2020
Ecologie Microbienne Lyon
2009-2020
Abstract Cystic fibrosis (CF) is the most common life-threatening genetic disease among Caucasians. CF patients suffer from chronic lung infections due to presence of thick mucus, caused by cftr gene dysfunction. The two commonly found bacteria in mucus are Staphylococcus aureus and Pseudomonas aeruginosa . It well known that early-infecting P. strains produce anti-staphylococcal compounds inhibit S. growth. More recently, it has been shown late-infecting develop commensal-like/coexistence...
Abstract In this work, surface‐enhanced Raman spectroscopy (SERS) method based on uncoated spherical gold nanoparticles as SERS substrate was applied for the detection and discrimination of three different bacterial strains: Gram‐positive Bacillus subtilis Lactobacillus rhamnosus GG Gram‐negative Escherichia coli. The exploitation bacteria spectra by multivariate data analysis (principal component partial least squares – discriminant analysis) proved robustness developed its suitability to...
Staphylococcus aureus (SA) is the major colonizer of lungs cystic fibrosis (CF) patients during childhood and adolescence. As age, prevalence SA decreases Pseudomonas aeruginosa (PA) becomes pathogen infecting adult lungs. Nonetheless, remains significant harbouring both PA are frequently found in worldwide cohort. The overall impact co-infection controversial. Furthermore, co-infecting isolates may compete or coexist. aim this study was to analyse if coexistence could lead worse clinical...
Abstract The NorA efflux pump lowers intracellular fluoroquinolone concentrations by expelling antibiotics through the membrane of Staphylococcus aureus . We identified 3‐aryl‐4‐methyl‐2‐quinolin‐2‐ones as compounds able to restore activity substrate, ciprofloxacin, against resistant S. strains, and acting inhibitors (EPI). In particular, 5‐hydroxy‐7‐methoxy‐4‐methyl‐3‐phenylquinolin‐2‐one ( 6 c ) presents both an EPI antimicrobial effect. Its efficacy safety make it a potential candidate...
LecA and LecB tetrameric lectins take part in oligosaccharide-mediated adhesion-processes of Pseudomonas aeruginosa. Glycomimetics have been designed to block these interactions. The great versatility P. aeruginosa suggests that the range application glycomimetics could be restricted genotypes with particular lectin types. likelihood having genomic genetic changes impacting interactions such as galactosylated fucosylated calix[4]arene was investigated over a collection strains from main...
The lvh region of the Legionella pneumophila genome, which encodes a type IV secretion system, is located on plasmid-like element in strains Paris (pP36) and Philadelphia (pLP45). pP36 has been described either integrated chromosome or excised as multi-copy plasmid, similar manner to pLP45. In this paper, chromosomal integration strain genome was described, occurring through site-specific recombination at 3′ end transfer-messenger RNA gene by between attachment sites, pathogenicity islands....
Staphylococcus aureus bacteremia is associated with high mortality and morbidity, requiring prompt appropriate antimicrobial treatment. Therefore, it important to detect methicillin-resistant S. (MRSA) rapidly from blood cultures. Two immunochromatographic tests, BinaxNow PBP2a, were directly applied 79 Bact/Alert bottles that positive for Gram cocci in cluster aggregations. Sensitivity specificity the identification of determination methicillin resistance 94% 87%, 100% 100%, respectively,...
ABSTRACT Since the introduction of type b Haemophilus influenzae vaccination, noncapsulated H. has become responsible for most cases invasive diseases. In our two septic arthritis, we isolated strains with β-lactamase-positive amoxicillin-clavulanate resistance (BLPACR). Thus, increasing prevalence BLPACR should be taken into account when empirical therapy is chosen arthritis.
Viral respiratory tract infections are common during early childhood. How they impact cystic fibrosis lung disease history in young children is poorly known. The principal aim of our study was to determinate frequency this population. Secondary outcomes were nature viral agents recovered and such infections. We conducted a prospective cohort 25 affected by aged less than 2 years. Nasal samplings taken systematically monthly or bimonthly with additional samples episodes. Ten pathogens tested...
Initial dosing and dose adjustment of intravenous tobramycin in children with cystic fibrosis (CF) is challenging. The objectives this study were to develop nonparametric population pharmacokinetic (PK) models CF be used for dosage design model-guided therapeutic drug monitoring. We performed a retrospective analysis PK data our children's center. Pmetrics package was simulations. Both the ratios maximal concentration MIC (Cmax/MIC) daily area under concentration-time curve (AUC24/MIC)...