A5057519788- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Advanced Biosensing Techniques and Applications
- Medical Imaging Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Perovskite Materials and Applications
- Nanoparticles: synthesis and applications
- Advanced Drug Delivery Systems
- Click Chemistry and Applications
- HER2/EGFR in Cancer Research
- Nanocomposite Films for Food Packaging
- Cell Adhesion Molecules Research
- Essential Oils and Antimicrobial Activity
- RNA Interference and Gene Delivery
- Nanomaterials for catalytic reactions
- Radiomics and Machine Learning in Medical Imaging
- Microfluidic and Capillary Electrophoresis Applications
- Hybrid Renewable Energy Systems
- Advanced battery technologies research
- Conducting polymers and applications
- Electrocatalysts for Energy Conversion
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Chronic Lymphocytic Leukemia Research
Umeå University
2021
Uppsala University
2013-2015
We present the synthesis and characterization of an efficient low cost solar-driven electrolyzer consisting Earth-abundant materials. The trimetallic NiFeMo electrocatalyst takes shape nanometer-sized flakes anchored to a fully carbon-based current collector comprising nitrogen-doped carbon nanotube network, which in turn is grown on fiber paper support. This catalyst electrode contains solely materials, support renders it effective despite metal content. Notably, bifunctional...
Medical imaging by use of immunotargeting generally relies on a labeled molecule binding to specific target the cell surface. It is important utilize both cell-based and time-resolved assays in order understand properties such molecular interactions relevant setting. In this report we describe detailed characterization interaction for AbD15179, promising CD44v6-targeting antibody fragment radio-immunotargeting. Influence labeling cell-line model protein kinetics was assessed using three...
Antibody-drug conjugates (ADC) have shown promising effects in cancer therapy by combining the target specificity of an antibody with toxicity a chemotherapeutic drug. As number therapeutic antibodies is significantly larger than those used as ADCs, there unused potential for more effective therapies. However, conjugation additional molecule to may affect interaction its target, altering association rate, dissociation or both. Any changes binding kinetics can subsequent on efficacy thus are...
Design of next-generation therapeutics comes with new challenges and emulates technology methods to meet them. Characterizing the binding either natural ligands or therapeutic proteins cell-surface receptors, for which relevant recombinant versions may not exist, represents one these challenges. Here we report characterization interaction five different antibody (Trastuzumab, Rituximab, Panitumumab, Pertuzumab, Cetuximab) their cognate target receptors using LigandTracer. The method offers...
Selective tumor targeting strategies based on cell surface molecules enable new personalized diagnosis and treatments, potentially lowering adverse effects increasing efficacy. Radio-immunotargeting generally relies a molecule binding to cancer-specific target. It is therefore important understand the properties of molecular interactions in their working environment how translate these measured vitro into vivo imaging situation.Time resolved interaction analysis was compared with...