A5054897198- Estrogen and related hormone effects
- Free Radicals and Antioxidants
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Plant-derived Lignans Synthesis and Bioactivity
- Nanoparticle-Based Drug Delivery
- Mitochondrial Function and Pathology
- Hormonal and reproductive studies
- Cancer therapeutics and mechanisms
- Glutathione Transferases and Polymorphisms
- Synthesis and biological activity
- Lanthanide and Transition Metal Complexes
- Phytoestrogen effects and research
- Bioactive Compounds and Antitumor Agents
- Steroid Chemistry and Biochemistry
- MicroRNA in disease regulation
- Crystallization and Solubility Studies
- Cancer Treatment and Pharmacology
- Ultrasound and Hyperthermia Applications
- Characterization and Applications of Magnetic Nanoparticles
- Plasma Applications and Diagnostics
- Natural Antidiabetic Agents Studies
- Curcumin's Biomedical Applications
- Cholinesterase and Neurodegenerative Diseases
- Chemotherapy-induced cardiotoxicity and mitigation
Pirogov Russian National Research Medical University
2014-2024
Ministry of Health of the Russian Federation
2017-2024
All-Russian Scientific Research Institute of Medicinal and Aromatic Plants
2016-2023
Endocrinology Research Center
2009
Recent studies have indicated the critical importance of mitochondria in induction and progression ferroptosis. There is evidence indicating that tert-butyl hydroperoxide (TBH), a lipid-soluble organic peroxide, capable inducing ferroptosis-type cell death. We investigated effect TBH on nonspecific membrane permeability measured by mitochondrial swelling oxidative phosphorylation NADH oxidation assessed fluo rescence. iron, as well their combinations, induced, with respective decrease lag...
Aim: The study is aimed at examining of action iron, DOX, and their complex on the Mitochondrial Permeability Transition Pore (MPTP) opening detecting possible protectors MPTP in conditions close to mitochondria-dependent ferroptosis. Background: Toxicity Doxorubicin (DOX) mainly associated with free iron accumulation mitochondrial dysfunction. DOX can provoke ferroptosis, iron-dependent cell death driven by membrane damage. considered as a common pathway leading development apoptosis,...
In order to evaluate the role of substituents at 3-C and 17-C in cytotoxic cytoprotective actions DHEA 5-AED molecules, their derivatives were synthesized by esterification using corresponding acid anhydrides or chlorides. As a result, seven compounds obtained: four (DHEA 3-propionate, 3-butanoate, 3-acetate, 3-methylsulfonate) three (5-AED 3,17-dipropionate, 3,17-dibutanoate). All these showed micromolar activity toward HeLa K562 human cancer cells. The maximum cytostatic effect during...
Agrimoniin is a polyphenol from the group of tannins with antioxidant and anticancer activities. It assumed that action agrimoniin associated activation mitochondria-dependent apoptosis, but its mitochondrial targets have not been estimated. We examined direct influence on different functions, including induction permeability transition pore (MPTP) as primary mechanism apoptosis. was isolated Agrimonia pilosa Ledeb by multistep purification. The content in resulting substance reached 80%,...
Endometriosis occurs in 10% of females reproductive age and ranks third among gynecological diseases, being one the causes infertility. The success endometriosis treatment depends on individually selected therapy based molecular-genetic characterization patient endometrial tissue. review addresses mechanisms development role gestagens pathogenesis this disease. We describe genetic epigenetic development, which lead to resistance endogenous progesterone, a key link endometriosis. Because...